환경분석과 독성보건 (Journal of Environmental Analysis, Health and Toxicology)

  • 제14권1호
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  • Pages.45-54
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  • 2011
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  • 2672-0175(pISSN)
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  • 2672-1139(eISSN)
한국환경분석학회 (The Korea Society for Environmental Analysis)
권호 표지

혈액과 모유 시료 중 과불화화합물 분석을 위한 전처리법 평가

Evaluation of Pretreatment Method for Analysis of Perfluorinated Compounds in Human Blood and Breast Milk Samples

  • 이응선 (부산대학교 사회환경시스템공학과) ;
  • 김희영 (부산대학교 사회환경시스템공학과) ;
  • 심원진 (부산대학교 사회환경시스템공학과) ;
  • 이지현 (부산대학교 사회환경시스템공학과) ;
  • 오정은 (부산대학교 사회환경시스템공학과) ;
  • 김형식 (부산대학교 약학과)
  • Lee, Eung-Sun (Department of Civil and Environmental Engineering, Pusan National University) ;
  • Kim, Hee-Young (Department of Civil and Environmental Engineering, Pusan National University) ;
  • Sim, Won-Jin (Department of Civil and Environmental Engineering, Pusan National University) ;
  • Lee, Ji-Hyun (Department of Civil and Environmental Engineering, Pusan National University) ;
  • Oh, Jeong-Eun (Department of Civil and Environmental Engineering, Pusan National University) ;
  • Kim, Hyung Sik (Department of Pharmacy, Pusan National University)
  • 발행 : 2011.03.30
⟨ 이전 논문 다음 논문 ⟩

초록

In this study, we evaluated extraction methods for the analysis of perfluorinated compounds (PFCs) in human serum and breast milk samples. The recovery efficiencies of ion pairing extraction (IPE) and solid phase extraction (SPE) in each serum and breast milk were examined. For serum samples, IPE was more efficient (recovery efficiency: 81~105%) than SPE. For breast milk samples, except for perfluorododecanoic acid (PFDoA), SPE showed better recoveries (80~98%) than IPE. As results of validity test, accuracy and precision were in the range of 81~130% and 1~18% in serum, and 54~130% and 2~17% in breast milk, respectively. We also analyzed PFCs in the cord serum and breast milk from 13 pregnant women using the method established in this study. In the cord serum, all PFCs except for perfluorobutane sulfonate, perfluoroheptane sulfonate and perfluorohexanoic acid were detected. In the breast milk, perfluorooctane sulfonate, perfluorooctanoic acid and PFDoA were detected dominantly compared with other PFCs.

키워드

참고문헌

  1. 김승규, J Environ Toxicol., 2008, 23(3), 143-164.
  2. U.S. Environmental Protection Agency, 2002, Revised draft hazard assessment of perfluorooctanoic acid and its salts. Office of Pollution Prevention and Toxic Risk Assessment Division, Washington, DC. Available from: URL: http://74.84.128.62/files/EPA_PFOA_110402.pdf
  3. Pistocchi A, Loos R. Environ Sci Technol., 2009, 43, 9237-9244. https://doi.org/10.1021/es901246d
  4. Inoue K, Okada F, Ito R, Kato S, Sasaki S, Nakajima S, Uno A, Saijo Y, Sata F, Yoshimura Y, Kishi R, Nakazawa H. Environ Health Persp. 2004, 112(11), 1204-1207. https://doi.org/10.1289/ehp.6864
  5. Jahnke A, Berger U. J Chromatogr A., 2009, 1216, 410-421. https://doi.org/10.1016/j.chroma.2008.08.098
  6. Directive 2006/122/ECOF of the European Parliament and of the Council of 12 December 2006. Official Journal of the European Union, L/372/32-34, 27. 12. 2006. Available from: URL: http://eur-lex.europa.eu/Lex-UriServ/LexUriServ.do?uri=OJ:L:2006:372:0032:0034:en:PDF
  7. UNEP, United Nations Environmental Programme (2009): Report of the Conference of the Parties of the Stockholm Convention on Persistent Organic Pollutants on the Work of Its Fourth Meeting. May 4-8, 2009. UNEP, Geneva. Available from:URL:http://chm.pops.int/Portals/0/Repository/COP4/UNEP-POPSCOP.4-38.English.pdf
  8. Lau C, Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Stanton ME, Butenhoff JL, and Stevenson LA, Toxicol Sci., 2003, 74, 382-392. https://doi.org/10.1093/toxsci/kfg122
  9. Martin MT, Brennan RJ, Hu W, Ayanoglu E, Lau C, and Ren H, Toxicol Sci., 2007, 97(2), 595-613. https://doi.org/10.1093/toxsci/kfm065
  10. Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL, Goldman LR, Environ Health Persp., 2007, 115(11), 1670-1677. https://doi.org/10.1289/ehp.10334
  11. Fei C, McLaughlin JK, Tarone R, Olsen J. Environ Health Persp., 2007, 115(11), 1677-1682. https://doi.org/10.1289/ehp.10506
  12. Monroy R, Morrison K, Teo K, Atkinson S, Kubwabo C, Stewart B, Foster WG. Environ Res., 2008, 108, 56-62. https://doi.org/10.1016/j.envres.2008.06.001
  13. Kannan K, Corsolini S, Falandysz J, Fillmann G, Kumar KS, Loganathan BG, Mohd MA, Olivero J, Wouwe NV, Yang JH, Aldous KM. Environ Sci Technol., 2004, 38, 4489-4495. https://doi.org/10.1021/es0493446
  14. Chung JY, Yoon HS, Ryu HY, Won JU, Paeng KJ, and Kim YJ, Anal Sci Technol., 2008, 21(3), 183-190.
  15. Villagrasa M, Alda ML, and Barcelo D, Anal Bioanal Chem., 2006, 386, 953-972. https://doi.org/10.1007/s00216-006-0471-9
  16. Sottani C, and Minoia C, Rapid Commun Mass SP., 2002, 16, 650-654. https://doi.org/10.1002/rcm.620
  17. Olsen GW, Church TR, Larson EB, van Belle G, Lundberg JK, Hansen KJ, Burris JM, Mandel JH, and Zobel LR, Chemosphere., 2004, 54, 1599-1611. https://doi.org/10.1016/j.chemosphere.2003.09.025
  18. Voogt P and Saez M, Trends Anal Chem., 2006, 25(4), 326-342. https://doi.org/10.1016/j.trac.2005.10.008
  19. 장상환, 이채관, 김대환, 김권복, 안진홍, 김휘동, 이창희, 김정호, 이종태, 대한산업의학회지, 2008, 20(3), 233-244.
  20. Kuklenyik Z, Reich JA, Tully JS, Needham LL, and Calafat AM, Environ Sci Technol., 2004, 38, 3698-3704. https://doi.org/10.1021/es040332u
  21. Karrman A, van Bavel B, Jarnberg U, Hardell L, and Lindstrom G, Anal Chem., 2005, 77, 864-870. https://doi.org/10.1021/ac049023c
  22. von Ehrenstein OS, Fenton SE, Kato K, Kuklenyik Z, Calafat AM, and Hines EP, Reprod Toxicol., 2009, 27, 239-245. https://doi.org/10.1016/j.reprotox.2009.03.001
  23. Official test methods of water quality, Ministry of Environment, 2010.
  24. Hansen KJ, Clemen LA, Ellefson ME, and Johnson HO, Environ Sci Technol., 2001, 35, 766-770. https://doi.org/10.1021/es001489z
  25. Harada K, Koizumi A, Saito N, Inoue K, Yoshinaga T, Date C, Fujii S, Hachiya N, Hirosawa I, Koda S, Kusaka Y, Murata K, Omae K, Shimbo S, Yakenaka K, Yakeshita T, Todoriki H, Wada Y, Watanabe T, and Ikeda M, Chemosphere., 2007, 66, 293-301. https://doi.org/10.1016/j.chemosphere.2006.05.010
  26. Kuklenyik Z, Needham LL, and Calafat AM, Anal Chem., 2005, 77, 6085-6091. https://doi.org/10.1021/ac050671l
  27. Karrman A, Mueller JF, van Bavel B, Harden F, Toms LM, and Lindström G, Environ Sci Technol., 2006, 40, 3742-3748. https://doi.org/10.1021/es060301u
  28. Karrman A, Ericson I, van Bavel B, Darnerud PO, Aune M, Glynn A, Lignell S, and Lindstrom G, Environ Health Persp., 2007, 115(2), 226-240.
  29. Tao L, Ma J, Kunisue T, Libelo EL, Tanabe S, and Kannan K, Environ Sci Technol., 2008, 42, 8597-8602. https://doi.org/10.1021/es801875v
  30. Haug LS, Thomsen C, and Becher G, J Chromatogr A., 2009, 1216, 385-393. https://doi.org/10.1016/j.chroma.2008.10.113
  31. Volkel W, Genzel-Boroviczeny O, Demmelmair H, Gebauer C, Koletzko B, Twardella D, Raab U, and Fromme H, Int J Hyg Envir Heal., 2008, 211, 440-446. https://doi.org/10.1016/j.ijheh.2007.07.024
  32. 최재원, 김정희, 김용연, 정팔진, 한국환경분석학회지, 2008, 11(3), 222-231.
  33. Yamashita N, Kannan K, Taniyasu S, Horii Y, Okazawa T, Petrick G, and Gamo T, Environ Sci Technol., 2004, 38, 5522-5528. https://doi.org/10.1021/es0492541
  34. Kim SK, Lee KT, Kang CS, Tao L, Kannan K, Kim KR, Kim CK, Lee JS, Park PS, Yoo YW, Ha JY, Shin YS, and Lee JH, Environ Pollut., 2011, 159, 169-174. https://doi.org/10.1016/j.envpol.2010.09.008