Journal of asthma, allergy and clinical immunology (천식및알레르기)

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Prevalence and Risk Factors of Food Allergy in Preschool Children in Seoul

수도권 학령전기 소아에서 식품알레르기의 유병률 및 위험인자

  • Jung, Young-Ho (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Childhood Asthma Atopy Center) ;
  • Ko, Hoon (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Childhood Asthma Atopy Center) ;
  • Kim, Hyung-Young (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Childhood Asthma Atopy Center) ;
  • Seo, Ju-Hee (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Childhood Asthma Atopy Center) ;
  • Kwon, Ji-Won (Department of Pediatrics, Bundang Hospital, Seoul National University College of Medicine) ;
  • Kim, Byoung-Ju (Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Kim, Hyo-Bin (Department of Pediatrics, Inje University Sanggye Paik Hospital, Inje University College of Medicine) ;
  • Lee, So-Yeon (Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jang, Gwang-Cheon (Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital) ;
  • Song, Dae-Jin (Department of Pediatrics, Guro Hospital, Korea University College of Medicine) ;
  • Kim, Woo-Kyung (Department of Pediatrics, Inje University Seoul Paik Hospital, Inje University College of Medicine) ;
  • Shim, Jung-Yeon (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Hong, Soo-Jong (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Childhood Asthma Atopy Center)
  • 정영호 (울산대학교 의과대학 서울아산병원 소아과학교실 소아천식아토피센터) ;
  • 고훈 (울산대학교 의과대학 서울아산병원 소아과학교실 소아천식아토피센터) ;
  • 김형영 (울산대학교 의과대학 서울아산병원 소아과학교실 소아천식아토피센터) ;
  • 서주희 (울산대학교 의과대학 서울아산병원 소아과학교실 소아천식아토피센터) ;
  • 권지원 (서울대학교 의과대학 분당서울대학교병원 소아과학교실) ;
  • 김병주 (인제대학교 의과대학 해운대백병원 소아과학교실) ;
  • 김효빈 (인제대학교 의과대학 상계백병원 소아과학교실) ;
  • 이소연 (한림대학교 의과대학 한림대학교성심병원 소아과학교실) ;
  • 장광천 (국민건강보험공단 일산병원 소아과학교실) ;
  • 송대진 (고려대학교 의과대학 구로병원 소아과학교실) ;
  • 김우경 (인제대학교 의과대학 서울백병원 소아과학교실) ;
  • 심정연 (성균관대학교 강북삼성병원 소아과학교실) ;
  • 홍수종 (울산대학교 의과대학 서울아산병원 소아과학교실 소아천식아토피센터)
  • Published : 2011.09.25
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Abstract

Background: The aim of this study was to investigate the prevalence of food allergy (FA) and determine its risk factors in the preschool urban children in Seoul, Korea. Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 933 pre-school children from nine urban areas of Seoul in Korea. The risk factor analysis was done by logistic regression analysis. Results: In preschool children, the lifetime and recent 12-month prevalence of FA symptoms were 21.0% and 10.6%, respectively. The lifetime prevalence of FA diagnosis was 6.1%, the prevalence of current FA (12-month symptoms and diagnosis) was 3.3%, and the recent 12-month prevalence of FA treatment was 3.6%. Blood eosinophils [0] in FA group and Non-FA group were 5.00$\pm$3.93% and 3.93$\pm$2.91%, respectively (P=0.002). The median total Immunoglobulin E (IgE) of FA group was 102 (interquatile [IQ] range 44.8~257) IU/mL, the median total IgE of Non-FA group was 70.9 (IQ range 70.9~161) IU/mL (P=0.001). Parental FA (adjusted odds ratio [aOR], 2.17; 95% confidence interval [CI], 1.22~3.85), past history of AD diagnosis (aOR, 3.69; 95% CI, 2.33~5.85), eczema on doctor's physical examination (aOR, 3.74; 95% CI, 2.16~6.47), use of antibiotics during infancy more than 3 days (aOR, 1.72; 95% CI, 1.08~2.73) were the independent risk factors for FA symptoms within 12 months. Conclusion: In preschool urban children in Seoul, the lifetime prevalence of FA diagnosis was 6.1%, the recent 12 month prevalence of FA treatment was 3.6%. The prevalences of AD and doctor examined AD in FA group were significantly higher compared to Non-FA group. Family history, and the use of antibiotics during infancy could be the independent risk factors for the development of FA.

Keywords

References

  1. Cianferoni A, Spergel JM. Food allergy: review, classification and diagnosis. Allergol Int. 2009;58:457-66. https://doi.org/10.2332/allergolint.09-RAI-0138
  2. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S116-25. https://doi.org/10.1016/j.jaci.2009.08.028
  3. Sicherer SH, Sampson HA. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol. 2007;120:491-503. https://doi.org/10.1016/j.jaci.2007.07.015
  4. Branum AM, Lukacs SL. Food allergy among U.S. children: trends in prevalence and hospitalizations. NCHS Data Brief. 2008;(10):1-8.
  5. Kim KE, Jeoung BJ, Lee KY. The incidence and principal foods of food allergy in children with asthma. Pediatr Allergy Respir Dis. 1995;5:96-106.
  6. Oh JW, Pyun BY, Choung JT, Ahn KM, Kim CH, Song SW, et al. Epidemiological change of atopic dermatitis and food allergy in school-aged children in Korea between 1995 and 2000. J Korean Med Sci. 2004;19:716-23. https://doi.org/10.3346/jkms.2004.19.5.716
  7. Liu AH, Jaramillo R, Sicherer SH, Wood RA, Bock SA, Burks AW, et al. National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol. 2010;126:798-806.e13. https://doi.org/10.1016/j.jaci.2010.07.026
  8. Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R, Pongracic J, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128:e9-17. https://doi.org/10.1542/peds.2011-0204
  9. Bjorksten B. Genetic and environmental risk factors for the development of food allergy. Curr Opin Allergy Clin Immunol. 2005;5:249-53. https://doi.org/10.1097/01.all.0000168790.82206.17
  10. Yocum MW, Butterfield JH, Klein JS, Volcheck GW, Schroeder DR, Silverstein MD. Epidemiology of anaphylaxis in Olmsted County: A population-based study. J Allergy Clin Immunol. 1999;104(2 Pt 1):452-6. https://doi.org/10.1016/S0091-6749(99)70392-1
  11. Sampson HA. Anaphylaxis and emergency treatment. Pediatrics. 2003;111(6 Pt 3):1601-8.
  12. Mai XM, Kull I, Wickman M, Bergstrom A. Antibiotic use in early life and development of allergic diseases: respiratory infection as the explanation. Clin Exp Allergy. 2010;40:1230-7. https://doi.org/10.1111/j.1365-2222.2010.03532.x
  13. Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA. Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics. 1998;101:E8.
  14. Sicherer SH, Sampson HA. Food hypersensitivity and atopic dermatitis: pathophysiology, epidemiology, diagnosis, and management. J Allergy Clin Immunol. 1999;104(3 Pt 2):S114-22. https://doi.org/10.1016/S0091-6749(99)70053-9
  15. Burks AW, James JM, Hiegel A, Wilson G, Wheeler JG, Jones SM, et al. Atopic dermatitis and food hypersensitivity reactions. J Pediatr. 1998;132:132-6. https://doi.org/10.1016/S0022-3476(98)70498-6