Journal of Biomedical and Translational Research

Research Institute of Veterinary Medicine Chungbuk National University (충북대학교 동물의학연구소)
권호 표지

Effects of ${\beta}$-Lapachone on Gastric Secretion

Park, Dongsun;Cho, In Geun;Yang, Yun-Hui;Kyung, Jangbeen;Kim, Dajeong;Choi, Chn-Kyoung;Kwak, Tae Hwan;Yoo, Sang Ku;Kim, Yun-Bae

  • Published : 20110900
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Abstract

The effects of $\beta$-lapachone on gastric secretion were investigated. The pylorus of male Sprague-Dawley rats were ligated and intraduodenally injected with $\beta$-lapachone, and the volume, pH, free HCl and total acidity of gastric fluid were measured 6 hours after the operation. The gastric secretion was inhibited by treatment with $\beta$-lapachone, in a dose-dependent manner. The gastric fluid was reduced to 42.9% of control level by 100 mg/kg of $\beta$-lapachone, leading to an increase of pH to 6.70 from 1.85 in control group. In parallel with the increase of pH, at this dosage, free HCl and total acidity decreased to 16.7% and 12.0%, respectively, of control levels. $\beta$-Lapachone exhibited ED50 values of 72, 46 and 47 mg/kg for the inhibition of gastric volume, free HCl and total acidity, respectively, implying a superior efficacy on gastric acid to volume. In comparison, pantoprazole (30 mg/kg) reduced the volume, free HCl and total acidity of gastric fluid to 53.0%, 26.0% and 25.0%, respectively, of control levels, resulting in the increase in pH to 6.36. In the present study, it was confirmed that $\beta$-lapachone at an appropriate dose (100 mg/kg) exerted a higher inhibitory effect on gastric secretion than pantoprazole (30 mg/kg), a well-known proton-pump inhibitor. Therefore, it is suggested that $\beta$-lapachone could be a candidate compound for the prevention or treatment of gastric ulcers induced by diverse psychological and physical stimuli.

Keywords

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