Allergy, Asthma & Immunology Research

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma

  • Zheng, Tao (Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine) ;
  • Yu, Jin-Ho (Division of Pediatric Allergy and Pulmonology, Asan Medical Center, Ulsan University College of Medicine) ;
  • Oh, Min-Hee (Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine) ;
  • Zhu, Zhou (Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine)
  • Published : 2011.04.01
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Abstract

Atopic dermatitis (AD) is an inflammatory disease characterized by pruritic skin lesions. The pathogenesis of AD may include disrupted epidermal barrier function, immunodysregulation, and IgE-mediated sensitization to food and environmental allergens. AD is also part of a process called the atopic march, a progression from AD to allergic rhinitis and asthma. This has been supported by multiple cross-sectional and longitudinal studies and experimental data. Research on the mechanisms of AD has been centered on the adaptive immune system with an emphasis on the T-helper 1 (Th1)-Th2 paradigm. Recently, the conceptual focus has largely shifted to include a primary defect in the epithelial barrier as an initial event in AD providing a significant insight into the disease initiation and pointing to a complex secondary interplay of environmental and immunological sequelae with barrier disruption. Further understanding of AD will help the development of more effective treatment for AD and ultimately, preventative algorithms for the atopic march. In this review we highlight recent advances in our understanding of the pathogenesis of AD and the atopic march.

Keywords

References

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  83. Sensitization to Molecular Components in 104 Atopic Dermatitis Patients in Relation to Subgroups of Patients Suffering from Bronchial Asthma and Allergic Rhinitis vol.63, pp.4, 2011, https://doi.org/10.14712/18059694.2020.59
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  97. Methicillin-resistant Staphylococcus aureus from infected skin lesions present several virulence genes and are associated with the CC30 in Brazilian children with atopic dermatitis vol.12, pp.1, 2011, https://doi.org/10.1080/21505594.2020.1869484
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