Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Long-term Mortality in Adult Orthotopic Heart Transplant Recipients

  • Jung, Sung-Ho (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Kim, Jae-Joong (Department of Cardiology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Choo, Suk-Jung (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Yun, Tae-Jin (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Chung, Cheol-Hyun (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Lee, Jae-Won (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, College of Medicine, University of Ulsan)
  • Published : 2011.05.01
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Abstract

Heart transplantation is now regarded as the treatment of choice for end-stage heart failure. To improve long-term results of the heart transplantation, we analyzed causes of death relative to time after transplantation. A total of 201 consecutive patients, 154 (76.6%) males, aged $\geq$ 17 yr underwent heart transplantation between November 1992 and December 2008. Mean ages of recipients and donors were 42.8 ${\pm}$ 12.4 and 29.8 ${\pm}$ 9.6 yr, respectively. The bicaval anastomosis technique was used since 1999. Mean follow up duration was 6.5 ${\pm}$ 4.4 yr. Two patients (1%) died in-hospital due to sepsis caused by infection. Late death occurred in 39 patients (19.4%) with the most common cause being sepsis due to infection. The 1-, 5-, and 10-yr survival rates in these patients were 95.5% ${\pm}$ 1.5%, 86.9% ${\pm}$ 2.6%, and 73.5% ${\pm}$ 4.1%, respectively. The surgical results of heart transplantation in adults were excellent, with late mortality due primarily to infection, malignancy, and rejection. Cardiac deaths related to cardiac allograft vasculopathy were very rare.

Keywords

References

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