Journal of Obesity & Metabolic Syndrome

Korean Society for the Study of Obesity (대한비만학회)
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Calorie Restriction and Obesity under the Regulation of SIRT1

SIRT1의 조절 하에서 칼로리 제한과 비만

Choi, Il-Sook;Kim, Kyung-Ah;Yim, Jung-Eun;Kim, Young-Seol

  • Published : 20111200
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Abstract

Obesity is one of the most important risk factors for various chronic diseases, especially related with environmental life style and eating habits. Obesity is also a risk factor of metabolic diseases, cardiovascular diseases, diabetes, and certain cancers. Numerous studies of calorie restriction (CR) in various organisms have shown several beneficial effects of not only decreased body fat and blood pressure, decreased inflammatory markers in plasma, increased insulin sensitivity, and improved lipid profile but also improved endothelial function, decreased oxidative damage by reducing energy flux and metabolism, and decreased ectopic fat accumulation. Furthermore, CR activates SIRT1, a nutrient-sensing deacetylase, involved in metabolic regulation and longevity. Resveratrol, as a mimetic of CR, is one of well-known sirtuin activating compounds. Resveratrol is related with longer lifespan by increasing insulin sensitivity, decreasing insulin-like growth factor-1, and increasing AMP-activated protein kinase activity. Therefore, the present review focuses on CR related with obesity and also the relationship between CR and SIRT1 in metabolic mechanism levels. Furthermore, we will introduce resveratrol, as an activator of SIRT1, and the beneficial effects of resveratrol.

비만은 환경, 생활습관, 식습관 등과 관련된 질환에 있어서 가장 중요한 위험인자이며, 대사성 질환, 심혈관계 질환, 당뇨및 암 등과 밀접한 연관성을 가지고 있다. 최근 칼로리제한(calorie restriction, CR)에 대한 많은 연구들을 통하여 체지방과 혈압의 감소 및 혈액 내 염증성 인자들의 감소, 인슐린 민감성과 혈액 내 지질조성의 향상 등이 발표되고 있다. 또한 대사조절 및 장수에 연관되며 영양소에 민감한 deacetylase인 SIRT1도 CR을 통하여 활성화됨이 보고되고 있다. 더불어, CR과 유사한 기능을 지니는 폴리페놀계의 일종인 resveratrol은 SIRT1 활성물질로써 인슐린의 민감성 증가, IGF-1의 감소 및 AMPK의 활성화의 기능 등과 함께, CR과 유사한 기능을 지닌 물질(sirtuin activating compounds, STACs)로 알려져 있다. 따라서 본 review에서는 비만과 연관된 CR에 관한 문헌들을 정리하고, CR과 SIRT1과 연관성을 대사적 메커니즘의 차원에서 설명하며, CR유사물질로 알려진 resveratrol의 효능에 관하여 보고하고자 한다.

Keywords

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