Korean Journal of Otorhinolaryngology-Head and Neck Surgery

Korean Society of Otolaryngology-Head and Neck Surgery (대한이비인후과학회)
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Relationship between Taste Genotype and Smoking and Alcohol Intake

미각 유전자와 흡연 및 알코올 섭취와의 관련성

  • Ye, Mi-Kyung (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Daegu) ;
  • Han, Ba-Da (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Daegu) ;
  • Lee, Jae-Wook (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Daegu) ;
  • Rhyu, Mee-Ra (Korea Food Research Institute) ;
  • Hyun, Dae-Sung (Department of Internal Medicine, College of Medicine, Catholic University of Daegu) ;
  • Shin, Seung-Heon (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Daegu)
  • 예미경 (대구가톨릭대학교 의과대학 이비인후과학교실) ;
  • 한바다 (대구가톨릭대학교 의과대학 이비인후과학교실) ;
  • 이재욱 (대구가톨릭대학교 의과대학 이비인후과학교실) ;
  • 류미라 (한국식품연구원) ;
  • 현대성 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 신승헌 (대구가톨릭대학교 의과대학 이비인후과학교실)
  • Published : 2011.12.25
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Abstract

Background and Objectives Genetic variations of bitter taste receptors (TAS2R) have shown different responses to bitter taste compounds and the frequencies of these variations were different within and between populations. Recently, single nucleotide polymorphisms (SNPs) in the TAS2R38 and TAS2R16 genes demonstrated a significant association with smoking and alcohol consumption in several studies. The aim of this study was to determine the relationship between bitter taste gene polymorphism and cigarette smoking and alcohol intake in Korean. Subjects and Method One hundred seventy four healthy normal volunteers were asked to fill in a questionnaire regarding demographic information, smoking history, frequency of alcohol intake. Peripheral blood samples were obtained for DNA extraction and genotyping. Single nucleotide polymorphisms were identified on the TAS2R38 and TAS2R16 genes. Results Haplotype analyses of the three SNPs inside the TAS2R38 gene allowed identifying of only two haplotypes that were associated with the non-taster phenotype (AVI homozygous) and the taster phenotype (PAV homozygous and PAV/AVI heterozygous). Common SNP within TAS2R16, which results in aminoacid change in the protein (K172N), is not demonstrated in this study. Smokers and frequent drinkers were more prevalent among non-tasters than tasters in male. Conclusion Functional variants in TAS2R38 correlated with cigarette smoking in the Korean male. Our findings suggest that taster status plays a role in governing the development of nicotine dependence.

Keywords

References

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