Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지

Trace Elements, Heavy Metals and Other Biochemical Parameters in Malignant Glioma Patients

Arslan, Mehmet;Demir, Halit;Arslan, Harun;Gokalp, A Samet;Demir, Canan

  • Published : 20110200
⟨ Previous Next ⟩

Abstract

Aim: We aimed to assess relevance of mineral, trace element and heavy metal levels in patients with malignant gliomas. Methods: In this study, erythrocyte catalase (CAT), and carbonic anhydrase (CA), serum copper (Cu.), zinc (Zn), lead (Pb), iron (Fe), cadmium (Cd), cobalt (Co), manganese (Mn), and magnesium (Mg) levels were measured in 22 healthy humans and 22 malignant glioma patients. Metal concentrations were assessed by atomic adsorption spectrophotometry, while biochemical methods were used for CAT and CA. Results: The Cd, Fe, Mg, Mn, Pb and Zn levels were significantly elevated in the patients as a whole compared to controls(P<0.05), while Cu was decreased and Co demonstrated no change. Although mean CAT activity were significantly lowered, CA exhibited significant increase. Conclusions: The results of the current study indicate that antioxidant enzymes may have a role in the genesis of considerable oxidative stress in patients with malignant glioma. CAT and CA seem to play particular roles in the pathophysiology of this disease.

Keywords

References

  1. Aebi H (1984). Catalase in vitro. Methods Enzymol, 105, 121-6.
  2. Ames BN (2001). DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res, 475, 7-20. https://doi.org/10.1016/S0027-5107(01)00070-7
  3. Cobanoglu U, Demir H, Sayir F, et al (2010). Some mineral, trace element and heavy metal concentrations in lung cancer. Asian Pacific J Cancer Prev, 11, 1383-8.
  4. Cobb CA, Youmans JR (1982). Glial and neuronal tumors of the brain in adults, in Youmans JR(ed): Neurological surgery. Philadelphia, WB Saunders, p 2762
  5. Cobanoglu U, Demir H, Duran M, et al (2010). Erythrocyte catalase and carbonic anhydrase activities in lung cancer. Asian Pacific J Cancer Prev, 11, 1377-82.
  6. Cocco P, Dosemeci M, Heineman EF (1988). Brain cancer and occupational exposure to lead. J Occup Environ Med, 40, 937-42.
  7. Collery P, Anghileri LJ, Coudoux P, et al (1981). Magnesium and cancer: clinical data. Magnesium Bull, 3, 11-20.
  8. Cotgreave IA, Moldeus P, Orrenius S (1988). Host biochemical defense mechanisms against prooxidants. Annu Rev Pharmacol Toxicol, 28, 189-212. https://doi.org/10.1146/annurev.pa.28.040188.001201
  9. Cuajungco MP, Lees GJ (1997). Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis, 4, 137-69. https://doi.org/10.1006/nbdi.1997.0163
  10. De Palma G, Goldoni M, Catalani S (2008). Metallic elements in pulmonary biopsies from lung cancer and control subjects. Acta Biomed, 79, 43-51.
  11. Diez M, Cerdan FJ, Arroyo M, et al (1989). Use of the copper/ zinc ratio in the diagnosis of lung cancer. Cancer, 63, 726-30. https://doi.org/10.1002/1097-0142(19890215)63:4<726::AID-CNCR2820630421>3.0.CO;2-P
  12. Florianczyk B, Kaczmarczyk R, Osuchowski J, et al (2007). Metallothionein and manganese concentrations in brain tumors. J Pre-Clin Clin Res, 11, 089-91.
  13. Gramlich TL, Hennigar RA, Spicer SS, et al (1990). Immunohistochemical localization of sodiumpotassiumstimulatedadenosine triphosphatase and carbonic anhydrase in human colon and colonic neoplasms. Arch Pathol Lab Med, 114, 415-9.
  14. Gonzales R, Auclair C, Voisin E, et al (1984). Superoxide dismutase, catalase, and glutathione peroxidase in red blood cells from patients with malign diseases. Cancer Res, 44, 4137-9.
  15. Guner G, Islekel H, Oto O, et al (1996). Evaluation of some antioxidant enzymes in lung carcinoma tissue. Cancer Lett, 103, 233-9. https://doi.org/10.1016/0304-3835(96)04226-7
  16. Halliwell B (2007). Oxidative stress and cancer: Have we moved forward? Biochem J, 40, 1-11.
  17. Hanninen MM, Haapasalo J, Haapasalo H et al (2009): Expression of iron-related genes in human brain and brain tumors. BMC Neurosci, 22, 10-36.
  18. Inskip PD, Linet MS, Heineman EF (1995). Etiology of brain tumors in adults. Epidemiol Rev, 17, 382-414. https://doi.org/10.1093/oxfordjournals.epirev.a036200
  19. Jarvela S, Parkkila S, Bragge H, et al (2008). Carbonic anhydrase 9 in oligodendroglial brain tumors. BMC Cancer, 8, 1471-2407.
  20. Levin VA, Wilson CB, Davis, et al (1979). Phase 3 comparison of BCNU, hydroxyurea, and radiation theraphy for treatment of primary malignant gliomas. J Neurosurg, 51, 526-32. https://doi.org/10.3171/jns.1979.51.4.0526
  21. Libermann AN, Ransohoff J (1979). Treatment of primary brain tumors. Med Clin North Am, 63, 835-48. https://doi.org/10.1016/S0025-7125(16)31677-7
  22. Mahabir S, Spitz MR, Barrera SL, et al (2006). Dietary zinc, copper and selenium, and risk of lung cancer. Int J Cancer, 120, 1108-15. https://doi.org/10.1002/ijc.22451
  23. Messner B, Knoflach M, Seubert A, et al (2009). Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and In vivo relevance arteriosclerosis. Arterioscler Thromb Vasc Biol, 29, 1392. https://doi.org/10.1161/ATVBAHA.109.190082
  24. Nawrot TS, Thijs L, Den Hond EM, et al (2002). An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis. J Hum Hypertens, 16, 123-31. https://doi.org/10.1038/sj.jhh.1001300
  25. Pastorekova S, Zatovicova M, Pastorek J (2008). Cancer associated carbonic anhydrases and their inhibition. Curr Pharm Des, 14, 685-98. https://doi.org/10.2174/138161208783877893
  26. Popov B, Gadjeva V, Valkanov P, et al (2003). Arch Physiol Biochem, 111, 455-9. https://doi.org/10.3109/13813450312331342328
  27. Rao GM, Rao AV, Raja A, et al (2000). Clinica Chimica Acta, 296, 203-12. https://doi.org/10.1016/S0009-8981(00)00219-9
  28. Rickli EE, Ghazanfar SAS, Gibbons BH, et al (1964). Carbonic anhydrase from human erytrocytes. Preparation and properties of two enzymes. J Biol Chem, 239, 1065-78.
  29. Robertson N, Potter C, Harris AL (2004). Role of carbonic anhydrase 9 in human tumor cell growth, survival, and invasion. Cancer Res, 64, 6160-5. https://doi.org/10.1158/0008-5472.CAN-03-2224
  30. Schirrmacher UO (1967). "Case of cobalt poisoning," Br Med J, 539, 544-5.
  31. Schwartz MK (1975).Role of trace elements in cancer. Cancer Res, 35, 3481-7.
  32. Sies H (1991). Oxidative stress: from basic research to clinical application. Am J Med, 91, 31-8.
  33. Solioz M, Odermatt A, Krapf R (1994). Copper pumping ATPases: common concept in bacteria and man. FEBS Lett, 346, 44-7. https://doi.org/10.1016/0014-5793(94)00316-5
  34. St.Clair DK, Oberley TD, Muse KE, et al (1994). Statement of manganese superoxide dismutase promotes cellular differentiation. Free Radic Biol Med, 16, 275-82. https://doi.org/10.1016/0891-5849(94)90153-8
  35. Stohs SJ, Bagchi D (1995). Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med, 18, 321. https://doi.org/10.1016/0891-5849(94)00159-H
  36. Supuran CT, Scozzafava A, Casini A (2003). Carbonic anhydrase inhibitors. Med Res Rev, 23, 146-89. https://doi.org/10.1002/med.10025
  37. Svastova E, Zilka N, Zat'ovicova M, et al (2003). Carbonic anhydrase IX reduces E-cadherin- mediated adhesion of MDCK cells via interaction with beta-catenin. Exp Cell Res, 290, 332-45. https://doi.org/10.1016/S0014-4827(03)00351-3
  38. Tas F, Hansel H, Belce A, et al (2005). Oxidative stress in breast cancer. Med Oncol, 22, 11-5. https://doi.org/10.1385/MO:22:1:011
  39. Turecky L, Kalina P, Uhlíkova E, et al (1984). Serum ceruloplasmin and copper levels in patients with primary brain tumors. Klin Wochenschr, 62, 187-9. https://doi.org/10.1007/BF01731643
  40. Venta PJ (1991). Carbonic anhydrases in mammalian cell culture and tumors. The Carbonic Anhydrases. Edited by SJ Dodgson, RE Tashian, G Gros, ND Carter. New York, Plenum Press, 71-8.
  41. Wijngaarden EV, Dosemeci M (2006). Brain cancer mortality and potential occupational exposure to lead: Findings. Int J Cancer, 119, 1136-44. https://doi.org/10.1002/ijc.21947
  42. Yokoyama S, Shatney CH, Mochizuki H, et al (1997). The potential role of fecal carbonic anhydrase II in screening for colorectal cancer. Am Surg, 63, 243-7.
  43. Zakrzewski A, Durska-Zakrzewska A, Skonieczny J, et al (1972). The content of some trace elements in blood serum of patients with larynx cancer. Acta Otolaryngol, 73, 227-9. https://doi.org/10.3109/00016487209138935