Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지

Cytotoxicity of a Plant Steroidal Saponin on Human Lung Cancer Cells

Huang, Wenfeng;Zou, Kun

  • Published : 20110200
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Abstract

Trillium tschonoskii Maxim has been used to treat several diseases, including cancers, in folk medicine. The primary objective of the present study was to test whether TTB2, a steroidal saponin isolated from n-BuOH extracts, might exert effects on cell survival, morphology, cell cycle, reactive oxygen species (ROS) production and mitochondrial function in a lung cancer cell line. It was found that TTB2 had anti-proliferative and morphological influence, leading to the loss of mitochondrial membrane potential (MMP) in a dose-dependent manner. A significant increase in the level of intracellular ROS and an accumulation of cells in the G2/M phases of the cell cycle were also observed in treated cells. In summary, our results indicated that this compound might have potential use for the treatment of cancer.

Keywords

References

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