Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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The Anti-Bacterial Activity of Supramolecule Containing Cosmetic Materials

초분자체 함유 화장제재의 항균 활성 효과

  • Yoo, Dong-Chan (Department of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Cho, Hyun-Nam (Department of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Kim, Kyoung-Ran (Department of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Byun, Hae-Jung (Department of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Kim, Jung-Hyun (Department of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Park, Hye-Bin (Department of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Kim, Hee-Joon (Department of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Bang, Dae-Suk (Department of Polymer Science and Engineering, Kumoh National Institute of Technology) ;
  • Yang, Seun-Ah (Center for Traditional Microorganism Resources (TMR), Keimyung University) ;
  • Khang, Gong-Won (LATIV CO., Ltd.) ;
  • Jeong, Ho-Soon (LATIV CO., Ltd.) ;
  • Jhee, Kwang-Hwan (Department of Applied Chemistry, Kumoh National Institute of Technology)
  • 유동찬 (금오공과대학교 응용화학과) ;
  • 조현남 (금오공과대학교 응용화학과) ;
  • 김경란 (금오공과대학교 응용화학과) ;
  • 변혜정 (금오공과대학교 응용화학과) ;
  • 김정현 (금오공과대학교 응용화학과) ;
  • 박혜빈 (금오공과대학교 응용화학과) ;
  • 김희준 (금오공과대학교 응용화학과) ;
  • 방대석 (금오공대 고분자공학과) ;
  • 양선아 (계명대학교 전통미생물자원개발 및 산업화 연구(TMR) 센터) ;
  • 강공원 ((주)라티브) ;
  • 정호순 ((주)라티브) ;
  • 지광환 (금오공과대학교 응용화학과)
  • Received : 2011.10.11
  • Accepted : 2011.11.07
  • Published : 2011.12.30
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Abstract

In this report, we have investigated the functional properties change of phytochemicals by the encapsulation using water soluble host, ${\beta}$-cyclodextrin. The cream, shampoo, bodywash, and hair tonic containing phytochemical supramolecules were produced by mixing the surfactants, fragrances and the oriental herbal extracts encapsulated with ${\beta}$-cyclodextrin. Shampoo and bodywash including the encapsulated phytochemicals exhibited anti-growth activity against Gram (+) and Malassezia furfur which is known to cause dandruff. In cytotoxicity test against HDF (human dermal fibroblast), we could not detect any toxicity when the supramolecules content was less than 1 mg/mL. Our results suggest that the supramolecule of ${\beta}$-cyclodextrin with phytochemicals could be a safe anti-bacterial agent for cosmeceuticals.

약용식물은 피부와 모발을 보호하는 잠재적 기능을 가지고 있다고 알려져 있다. 약용식물의 유용 성분들은 대부분 비수용성 약용성분들이므로 수용성 분자 담지체인 ${\beta}$-cyclodextrin을 이용하여 초분자 복합체를 형성시켜 기능성의 변화를 살펴보았다. 약용식물의 유용 성분이 함유된 크림, 샴푸, 바디워시, 그리고 헤어토닉은 계면활성제, 방향제, 약용식물 추출물과 ${\beta}$-cyclodextrin을 혼합하여 제조하였다. 복합체를 함유한 샴푸 및 바디워시에서 그람 양성균들과 비듬균으로 알려져 있는 효모에 대한 항균활성과 균 성장억제 효과를 확인하였다. HDF (human dermal fibroblast)에 대한 초분자체의 독성실험결과, 초분자체의 함량이 1 mg/mL 이하의 경우에서는 세포 독성이 나타나지 않았다. 본 연구결과는 약용식물 추출물과 약용성분 초분자 복합체에 대한 세포무독성을 확인하고 항균활성을 확인함으로써 향후 기능성화장품 제조 시 안정성과 기능성의 과학적 근거를 확보하였다고 사료된다.

Keywords

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