Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Study on the Anti-inflammatory Effect of Kaempferol and Kaempferol Rhamnosides Isolated from Hibiscus cannabinus L.

양마에서 분리한 Kaempferol 및 그 배당체의 항염증 효과에 관한 연구

  • 이근하 ((주)모아캠 기술연구소) ;
  • 조영롱 ((주)모아캠 기술연구소) ;
  • 주철규 ((주)모아캠 기술연구소) ;
  • 주연정 ((주)모아캠 기술연구소) ;
  • 권순상 ((주)모아캠 기술연구소) ;
  • 박청 ((주)모아캠 기술연구소)
  • Received : 2011.09.26
  • Accepted : 2011.11.30
  • Published : 2011.12.30
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Abstract

In this study, to evaluate the anti-inflammatory effects of kaempferol and its rhamnosides isolated from Hibiscus cannabinus L. leaves, we investigated UVB-induced inhibitory effects on inflammatory reaction by measuring the cytokine as the prostaglandin ($PGE_2$), interleukine-6 (IL-6) and interleukine-8 (IL-8). We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC (thymus and activation-regulated chemokine) and $PGE_2$. Kaempferol and ${\alpha}$-rhamnoisorobin showed inhibition activity of TARC generated to compared to positive control. Kaempferol, ${\alpha}$-rhamnoisorobin and afzelin Inhibited the release of $PGE_2$. Also, only kaempferol significantly inhibited interleukine-6 (IL-6), interleukine-8 (IL-8) among UVB-induced inflammatory cytokine.

Keywords

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