Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Phytochemical Constituents and Anticancer Activity of Sphagnum palustre Extract

물이끼 추출물의 식물화학적 성분 및 항암활성 연구

  • Nam, Jung-Hwan (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Jeong, Jin-Cheol (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Yoon, Young-Ho (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Hong, Su-Young (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Kim, Su-Jeong (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Jin, Yong-Ik (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Lee, Ye-Jin (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Yoo, Dong-Lim (Highland Agricultre Research Center, National Institute of Crop Science, RDA) ;
  • Lee, Kyung-Tae (Department of pharmaceutical, College of Pharmacy, Kyung-Hee University) ;
  • Park, Hee-Juhn (Department of Pharmaceutical Engineering, College of Health Sciences, Sangji University)
  • 남정환 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 정진철 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 윤영호 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 홍수영 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 김수정 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 진용익 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 이예진 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 유동림 (농촌진흥청 국립식량과학원 고령지농업연구센터) ;
  • 이경태 (경희대학교 약학대학 약학과) ;
  • 박희준 (상지대학교 보건대학 제약공학과)
  • Received : 2010.08.30
  • Accepted : 2010.11.26
  • Published : 2011.02.28
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Abstract

Sphagnum palustre is a semi aquatic moss. S. palustre has been used as Korean traditional medicine to treat cardiac pain and stroke. This study was carried out to analyze phytochemical constituents of S. palustre and investigate the biological activity for the promotion of human health. At first, we isolated seven compounds from the ethanolic extract of this plant, and their structures were characterized by spectroscopic methods. Their structures were characterized to be Coumarin(1), Caffeic acid(2), Quercetin(3), Astragalin(4), Luteolin(5), Chlorogenic acid(6), Rutin(7) were for the first time reported from this source. The ethanol extract from S. palustre which was tested for its anticancer activity against three human tumor cell line by in vitro assay.

본 연구에서는 척리 즉 물이끼를 이용한 고부가가치 기능성 소재를 개발하기 위하여 물이끼의 Ethanol 추출물을 이용한 항암활성과 식물화학적 성분연구를 수행 하였다. 3종의 암세포주(A549, HeLa, SK-OV-3)에 대하여 세포독성연구를 수행해 본 결과 폐암세포주인 A549에서 유의성 있는 결과를 보였다. 이 결과는 난치성 질환인 암을 치료하려는 목적 의약품 보다는 Chemopreventive agent로서의 예방 의학적 기능성 소재로 충분한 가치가 있음이 사료 되어지기에 식물화학적 성분연구를 실시하여 7종의 화합물(Comp.1 : Coumarin, Comp.2 : Caffeic acid, Comp.3 : Quercetin, Comp.4 : Astragalin, Comp.5 : Luteolin, Comp.6 : Chlorogenic acid, Comp.7 : Rutin) 를 분리하여 구조동정 하였다.

Keywords

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