Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Effects of Ixeris dentata ext. on Lowering Lipid and Anti-oxidation

씀바귀의 지질강하 및 항산화효과

  • Lee, Eun (Department of Pharmaceutical Engineering, College of Health Sciences, Sangji University)
  • 이은 (상지대학교 보건과학대학 제약공학과)
  • Received : 2010.09.28
  • Accepted : 2010.12.15
  • Published : 2011.02.28
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Abstract

To investigate effects of Ixeris dentata EtOH ext. on lowering lipid levels and anti-oxidation activity, hyperlipidemic rats were treated with Ixeris dentata EtOH ext. and lipid levels and anti-oxdation activity were measured. The Ixeris dentata EtOH ext. groups showed low concentration of plasma FFA, plasma triglyceride, plasma total cholesterol, and plasma LDL-cholesterol compared to control group. However, concentration of plasma HDLcholesterol was not significantly different among all the treatment groups. The Ixeris dentata EtOH ext. groups showed lower level of liver total cholesterol, liver triglyceride, plasma TBARS, and liver TBARS than those of control group. The Ixeris dentata EtOH ext. groups also showed higher level of GSH-Px activity, SOD activity, and CAT activity than those of control group. Moreover, the Ext. showed lower level of TNF-${\alpha}$, Apo-B, Apo-E, and leptin expression than those of control group. The results in this study shows that the Ixeris dentata EtOH ext. have positive effect in lowering lipid level, and anti-oxidative activity.

씀바귀추출물이 비만을 유도한 흰쥐의 지질강하 및 항산화 효과에 미치는 영향을 검토하였다. 혈장 유리지방산과 triglyceride농도는 대조군과 비교하여 씀바귀추출물 투여군은 농도 의존적으로 낮은 값을 나타내었다. 혈장 내 total cholesterol 농도와 LDL-cholesterol 농도는 씀바귀추출물 투여군 모두에서 감소하는 경향을 보였다. 그러나, HDL-cholesterol농도는 처리군 들 간에 유의한 차이를 나타내지 않았다. 간장 total cholesterol과 triglyceride량은 씀바귀추출물 투여군 들이 대조군보다 낮은 값을 나타내었다. 혈장 및 간장의 TBARS 농도는 씀바귀추출물 투여군 들 모두가 대조군보다 유의하게 낮은 값을 나타내었다. GSH-Px, SOD 및 CAT의 활성치는 씀바귀추출물 투여군 들이 대조군보다 높은 값을 나타내었다. TNF-${\alpha}$, Apo-B, Apo-E 및 Leptin의 gene expression은 씀바귀추출물 투여군이 대조군보다 낮은 expression을 나타내었다. ${\beta}$-actin expression에 대한 TNF-${\alpha}$, Apo-B, Apo-E 및 Leptin의 gene expression의 비율은 TNF-${\alpha}$와 Apo-E는 대조군보다 씀바귀추출물 투여군 들이 낮은 경향을 보였으나, Apo-B 및 Leptin의 비율은 대조군을 비롯한 씀바귀추출물 투여군 들 간에 유의한 차이를 나타내지는 않았다. 이상의 결과들을 종합해보면, 씀바귀 추출물은 지질강하 및 항산화에 긍정적인 효과를 나타내었음을 시사해준다.

Keywords

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