Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Therapeutic Effects of Hovenia Dulcis Thunb Extract on $CCl_4$ Induced Liver and Kidney Damage in Rats

Carbon Tetrachloride로 유발된 Rat의 간장과 신장 손상시 헛개나무 추출액의 치료효과

  • Kim, Hong-Tae (Busan Metropolitan City Institute of Health and Environment) ;
  • Kim, Dae-Dong (Gana Animal Clinic) ;
  • Ku, Sae-Kwang (College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Ju-Wan (College of Veterinary Medicine, Kyungpook National University) ;
  • Lim, Mee-Kyung (College of Human Ecology, Kyungpook National University) ;
  • Oh, Tae-Ho (College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Keun-Woo (College of Veterinary Medicine, Kyungpook National University)
  • 김홍태 (부산광역시 보건환경연구원) ;
  • 김대동 (구미 가나동물병원) ;
  • 구세광 (대구한의대학교 한의과대학) ;
  • 김주완 (경북대학교 수의과대학) ;
  • 임미경 (경북대학교 생활과학대학) ;
  • 오태호 (경북대학교 수의과대학) ;
  • 이근우 (경북대학교 수의과대학)
  • Accepted : 2010.10.11
  • Published : 2011.02.28
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Abstract

Hovenia dulcis Thunb (HDT) has been known folk medicine and has been used as therapeutic drug in the treatment of liver disease. Also it has been used as a detoxifying agents for alcoholic poisoning and promoting diuresis. However, there has not been any study on therapeutic effect of Hovenia dulcis extract on $CCl_4$ induced liver and kidney damage in rats. In this study, we report on therapeutic effects of Hovenia dulcis extract on $CCl_4$ induced liver and kidney damage in rats. Rats were divided into four groups of eighteen animals. Control group (DW) was administrated with distilled water 2.5 mL/kg per peritonial administration and then $CCl_4$ group (CCl) was administrated $CCl_4$ 2.5 mL/kg per peritonial administration, $CCl_4$+HDT extract group ($CCl_4$+HDT) was administrated HDT extrat (100 mg/kg) after $CCl_4$ 2.5 mL/kg administration, $CCl_4$+Silymarin group ($CCl_4$+Sily) was administrated Silymarin (50 mg/kg) after $CCl_4$ 2.5 mL/kg administration. The complete blood cell (CBC) count of RBC, WBC, PCV, Hb, MCH, MCV, MCHC and blood chemistry profile of AST, ALT, GGT, ALP, Total choloesterol, Tryglyceride, Total bilirubin, Amylase, Glucose, BUN, Creatinine, Lipase and pathologic changes were observed for 7 days after administration of D.W., $CCl_4$, $CCl_4$+HDT extract, $CCl_4$+Silymarin. The results are as follows : 1. RBC and PCV were significantly (p < 0.01) increased in all groups compared to D.W. but hemoglobin, MCH, MCV and MCHC were not showed significant difference during experimental periods. 2. AST, ALT, T-cholesterol, T-bilirubin, TG were significantly (p < 0.05) increased in all groups on day 3 compared to D.W. and were normal on day 7. 3. ALP was significantly (p < 0.05) decreased in $CCl_4$+HDT group on day 3 but Amylase was not showed significant difference during experimental periods. 4. BUN was significantly (p < 0.05) increased in $CCl_4$ group on day 7, but $CCl_4$+HDT group and $CCl_4$+Sily group were normal. Creatninie was significantly (p < 0.05) increased in $CCl_4$ group on day 3 and normal on day 7 but $CCl_4$+HDT group and $CCl_4$+Sily group were not showed significant difference during experimental periods.

Keywords

References

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