Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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Phenylpropanoids in radioregulation: double edged sword

  • Kim, Wan-Yeon (College of Natural Sciences, Department of Biological Sciences, Pusan National University) ;
  • Seong, Ki-Moon (Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd.) ;
  • Youn, Bu-Hyun (College of Natural Sciences, Department of Biological Sciences, Pusan National University)
  • Accepted : 2011.04.07
  • Published : 2011.06.30
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Abstract

Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals found in plants, have been identified as potential radiotherapeutic agents due to their anti-cancer activity and relatively safe levels of cytotoxicity. Various studies have proposed that these compounds could not only sensitize cancer cells to radiation resulting in inhibition of growth and cell death but also protect normal cells against radiation-induced damage. This review is intended to provide an overview of recent investigations on the usage of phenylpropanoids in combination with radiotherapy in cancer treatment.

Keywords

Acknowledgement

Supported by : Pusan National University

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