Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber

  • Hung, Tran Manh (Faculty of Chemistry, University of Natural Science, National University Hochiminh city) ;
  • Thuong, Phuong Thien (National Institute of Medicinal Materials) ;
  • Nhan, Nguyen Trung (Faculty of Chemistry, University of Natural Science, National University Hochiminh city) ;
  • Mai, Nguyen Thi Thanh (Faculty of Chemistry, University of Natural Science, National University Hochiminh city) ;
  • Quan, Tran Le (Faculty of Chemistry, University of Natural Science, National University Hochiminh city) ;
  • Choi, Jae-Sue (Faculty of Food Science and Biotechnolgy, Pukyoung National University) ;
  • Woo, Mi-Hee (College of Pharmacy, Catholic University of Daegu) ;
  • Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • Received : 2011.04.16
  • Accepted : 2011.05.10
  • Published : 2011.06.30
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Abstract

Several isoquinoline alkaloids (1 - 18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the $IC_{50}$ values ranging from $10.2{\pm}0.5\;{\mu}M$ to $24.5{\pm}1.6\;{\mu}M$, meanwhile, compound 14 - 17 exhibited strong inhibitory activity with $IC_{50}$ values from $2.1{\pm}0.2$ to $5.5{\pm}0.3\;{\mu}M$. Compounds 14 - 17 exhibited selective inhibition for AChE compared with BuChE. The isoquinoline alkaloid possesses aromatic methylenedioxy groups and quaternary nitrogen atoms are crucial for the anti-cholinesterase inhibitory activity.

Keywords

References

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