Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
권호 표지
DOI QR코드

DOI QR Code

Systematic Studies on Galgeun-tang(gegen-tang, kakkon-to) for Establishment of Evidence Based Medicine

표준한방처방의 EBM 구축을 위한 갈근탕(葛根湯) 문헌 분석 연구

  • Lee, Jun-Kyoung (Herbal medicine EBM research center, Korea Institute of Oriental Medicine) ;
  • Kim, Jung-Hoon (Herbal medicine EBM research center, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Herbal medicine EBM research center, Korea Institute of Oriental Medicine)
  • 이준경 (한국한의학연구원 한약 EBM연구센터) ;
  • 김정훈 (한국한의학연구원 한약 EBM연구센터) ;
  • 신현규 (한국한의학연구원 한약 EBM연구센터)
  • Received : 2011.04.19
  • Accepted : 2011.06.13
  • Published : 2011.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this report was to provide the information of activity and safety of galgeun-tang by analyzing domestic/international papers and theses about galgeun-tang. Methods : Domestic/international papers and theses related to galgeun-tang were reviewed and analyzed. These papers were then classified by efficacy, or clinical trials. Results : The basic pharmacological experiment showed antipyretic, analgesic and anti-virus and anti-oxidant efficacy of galgeun-tang. In the case report of galgeun-tang, it showed therapeutic effect for patient with chronic rhinitis. But administration of galgeun-tang induced pruritic eruption in the two case report as a side effects of galgeun-tang. Conclutions : galgeun-tang showed tantipyretic, analgesic and anti-virus and anti-oxidant efficacy in the basic pharmacological experiment. Also, galgeun-tang showed therapeutic effect for patient with chronic rhinitis. But it was reported that galgeun-tang induced pruritic eruption in two case report, so physicians should be aware of the potential side effects.

Keywords

References

  1. 이남헌, 하혜경, 이호영, 정다영, 최지윤, 이준경, 신현규. EBM 기반구축을 위한 오적산 연구논문 분석. 대한한의학 방제학회지. 2008;16(2):1-9.
  2. 이준경, 이남헌, 하혜경, 이호영, 정다녕, 최지윤, 서창섭, 신현규. EBM 기반구축을 위한 육미지황탕 문헌 분석 연구. 동의생리병리학회지. 2009;23(1):15-26.
  3. 김정훈, 이준경, 하혜경, 서창섭, 이호영, 정다영, 이남헌, 이진아, 황대선, 신현규. EBM 구축을 위한 사물탕 연구 문헌 분석. 동의생리병리학회지. 2009;23(4):779-88.
  4. 이준경, 이남헌, 하혜경, 이호영, 서창섭, 정다영, 이진아, 신현규. EBM 구축을 위한 쌍화탕 연구 문헌 분석. 한국한의학연구원논문집. 2008;14(3):41-7.
  5. 박영순. 한방의 약리해설. 서울:아카데미서적. 2002:196-202.
  6. 이지혜, 이재훈, 마충제, 마진열. 갈근탕 추출물의 단회투여 독성 시험. 한국한의학연구원논문집. 2009;15(1):79-83.
  7. 양태규, 김윤범, 채병윤. 葛根湯과 加味葛根湯의 抗알레르기 및 消炎, 解熱, 鎭痛作用에 대한 實驗的 硏究. 大韓眼耳鼻咽喉皮膚科學會誌. 2002;15(1):76-95.
  8. 曺義煥, 金一赫. 醫藥品의 倂用 投與 效果에 관한 硏究(I); 葛根湯 엑기스와 Aspirin의 倂用 投與가 抗炎 및 鎭痛作用에 미치는 영향. 생약학회지. 1985;16(1):7-11.
  9. Itami T, Ema M, Sakamoto J, Hosoda K, Noguchi M, Kawasaki H. Antipyretic effects of tradi tional chinese medicines in bacterial endotoxin-induced febrile rabbits. Yakugaku Zasshi. 1992;112(2):129-34. https://doi.org/10.1248/yakushi1947.112.2_129
  10. Kurokawa M, Tsurita M, Brown J, Fukuda Y, Shiraki K. Effect of interleukin-12 level aug mented by Kakkon-to, a herbal medicine, on the early stage of influenza infection in mice. Antiviral Research. 2002;56:183-8. https://doi.org/10.1016/S0166-3542(02)00104-3
  11. Wu MS, Yen HR, Chang CW, Peng TY, Hsieh CF, Chen CJ, Lin TY, horng JT. Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export. J Ethnopharm. 2011;134:614-23. https://doi.org/10.1016/j.jep.2011.01.005
  12. 마진열, 김진숙, 정규용, 박갑주. Vibrio parahemolyticus에 대한 한방처방 (금궤요략) 및 그 구성약재의 항균활성에 관한 연구. 한국한의학연구원논문집. 2000;6(1)107-16.
  13. Nagasaka K, Kurokawa M, Imakita M, Terasawa K, Shiraki K. Efficacy of kakkon-to, a traditional herb medicine, in herpes simplex virus type 1 infection in mice. J Med Virol. 1995;46(1):28-34. https://doi.org/10.1002/jmv.1890460107
  14. Muraoka K, Yoshida S, Hasegawa K, Nakanishi N, Fukuzawa I, Tomita A, Cyong JC. A pharmacologic study on the mechanism of action of Kakkon-to: body temperature elevation and phagocytic activation of macrophages in dogs. J Altern Complement Med. 2004;10(5):841-9.
  15. 趙大衍. 葛根湯이 면역조절작용에 미치는 영향. 원광대학교 대학원. 2005.
  16. 권창호. 갈근탕 투여가 흰 쥐의 스트레스 저항 반응에 미치는 영향에 관한 연구. 한국생약학회지. 1974;5(4):217-22.
  17. 박영근, 권창호, 葛根湯이 發熱 rat의 肝腸代射酵素 활성에 미치는 影響에 관한 硏究. 경희약대논문집. 1976;4:4-9.
  18. Sugiyama A, Takahara A, Satoh Y, Yoneyama M, Saegusa Y, Hashimoto K. Cardiac effects of clinically available Kampo medicine assessed with canine isolated, blood-perfused heart preparations. Jpn J Pharmacol. 2002;88:307-13. https://doi.org/10.1254/jjp.88.307
  19. 신정미. 갈근탕과 갈근으로부터 항노화 물질의 탐색. 원광대학교 한의학전문대학원. 2006.
  20. 김동렬, 곽결순, 정석문, 이승철, 하정욱. 시판 갈근탕의 항산화능의 비교. J Korean Soc Food Sci Nutr. 2003;32(5):728-32. https://doi.org/10.3746/jkfn.2003.32.5.728
  21. Yamamoto T, Fujiwara K, Yoshida M, Kageyama-Yahara N, Kuramoto H, Shibahara N, Kadowaki M. Therapeutic effect of kakkonto in a mouse model of food allergy with gastrointestinal symptoms. Int Arch Allergy immunol. 2009;148(3):175-85. https://doi.org/10.1159/000161578
  22. 朴昭玧. 갈근탕 추출물이 NIH3T3 섬유모세포의 카드뮴독성에 대한 수복효과. 원광대학교 한의학전문대학원. 2006.
  23. Yano H, Hiraki S, Hayasaka S. Effects of Kakkon-to and Sairei-to on experimental elevation of aqueous flare in pigmented rabbits. Jpn J Ophthalmol. 1999;43(4):279-84. https://doi.org/10.1016/S0021-5155(99)00019-2
  24. Ikeda N, Hayasaka S, Nagaki Y, Hayasaka Y, Kadoi C, Matsumoto M. Effects of kakkon-to and sairei-to on aqueous flare elevation after complicated cataract surgery. Am J Chin Med. 2002;30:347-53. https://doi.org/10.1142/S0192415X02000375
  25. 한은정, 김윤범. 비증상을 동반한 Maxillary Sinus Retention Cyst 1예. 대한안이비인후피부과학회지. 2003;16(1):191-7.
  26. Akita H, Sowa J, Makiura M, Akamatsu H, Matsunaga K. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact dermatitis. 2003;48(6):348-9. https://doi.org/10.1034/j.1600-0536.2003.00151.x
  27. Fujimoto N, Tajima S. Extensive fixed drug eruption due to the Japanese herbal drug "kakkon-to". Br J Dermatol. 2003;49(6):1303-5.