The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Samhwangsasim-tang, Samigangap-tang and Bangtan-tang on Blood Pressure in Stroke Prone Spontaneously Hypertensive Rats

뇌졸중성(腦卒中性) 본태성(本態性) 고혈압(高血壓) 백서(白鼠) 모델에서 삼황사심탕(三黃瀉心湯), 사미강압탕(四味降壓湯), 방탄탕(防癱湯)의 혈압(血壓)에 미치는 영향(影響)

  • Kim, Eun-Ju (Dept. of Oriental Medicine & Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Hye-Yoom (Dept. of Oriental Medicine & Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jae-Yun (Dept. of Oriental Medicine & Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jun-Kyoung (Dept. of Oriental Medicine & Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Seung-Ju (Dept. of Oriental Medicine & Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Kyoung-Min (Institute of Jinan Red Ginseng) ;
  • Kang, Dae-Gill (Dept. of Oriental Medicine & Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 김은주 (원광대학교 한의과대학 및 한의학전문대학원) ;
  • 김혜윰 (원광대학교 한의과대학 및 한의학전문대학원) ;
  • 이재윤 (원광대학교 한의과대학 및 한의학전문대학원) ;
  • 이준경 (원광대학교 한의과대학 및 한의학전문대학원) ;
  • 김승주 (원광대학교 한의과대학 및 한의학전문대학원) ;
  • 최경민 (진안 홍삼연구소) ;
  • 강대길 (원광대학교 한의과대학 및 한의학전문대학원)
  • Received : 2011.02.02
  • Accepted : 2011.03.10
  • Published : 2011.03.30
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Abstract

Objectives : The aim of the present study is to investigate the hypotensive effect of Samhwangsasim-tang (SHSST), Samigangap-tang (SMGAT) and Bangtan-tang (BTT) in stroke-prone spontaneously hypertensive rats (SHR-SP). Methods : SHR-SP rats were treated with SHSST, SMGAT and BTT at dose of 200 mg/kg/day orally for 5 weeks, respectively. Results : Treatment SHR-SP rats with SMGAT significantly lowered blood pressure but not in the SHSST or BTT treat groups. On the other hand, SHSST, SMGAT and BTT ameliorated endothelium-dependent and independent vascular relaxation in the phenylephrine-precontracted aorta and carotid artery, respectively. Conclusions : These results indicated that SMGAT has an antihypertensive effect and SHSST, SMGAT and BTT improve vascular function in stroke-prone hypertensive rat model, respectively.

Keywords

References

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