The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary induced by Estradiol Valerate in rats

당귀(當歸)가 Estradiol valerate에 의하여 유발된 다낭성난소에 미치는 영향

  • Kim, Hyung-Woo (School of Korean medicine, Pusan National University) ;
  • Choi, Eu-Gene (School of Korean medicine, Pusan National University) ;
  • Chung, Hee-Jin (School of Korean medicine, Pusan National University) ;
  • Joung, Young-Min (School of Korean medicine, Pusan National University) ;
  • Shin, Dong-Sung (School of Korean medicine, Pusan National University) ;
  • Cho, Su-In (School of Korean medicine, Pusan National University)
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 최유진 (부산대학교 한의학전문대학원) ;
  • 정희진 (부산대학교 한의학전문대학원) ;
  • 정영민 (부산대학교 한의학전문대학원) ;
  • 신동선 (부산대학교 한의학전문대학원) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Received : 2011.02.15
  • Accepted : 2011.03.10
  • Published : 2011.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : This study was designed to investigate the effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats. Methods : We investigated the effects of AGR on Changes in body weights and food and water uptake for 5 weeks. In addition, we examined the effects on ovary weights. Finally, we also observed histopathological changes in PCO rats. Results : Treatment with AGR did not affect body weights, amount of food and water uptake. Administration group of AGR restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in AGR group compared with non-treated control group. Conclusion : These results suggest that AGR can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.

Keywords

References

  1. 대한산부인과학회. 부인과학. 서울 : 고려의학. 2007 : 362-71.
  2. 민응기. 다낭성 난소 증후군. 대한산부인과학회지. 2008 ; 51(8) : 805-819.
  3. 김정훈. 다능성난소증후군 치료의 최신지견. 대한산부인과학회지. 2005 ; 48(8) : 1851-1869.
  4. 김동일, 윤종원, 이태균. 다낭성난소증후군의 문헌적고찰. 대한한방부인과학회지. 1997 ; 10(1) : 73-91
  5. 전국한의과대학본초학교실교수 공저. 본초학. 서울 : 영림사, 2000 ; 578-580.
  6. 우정화, 최인영, 조여원. 식이로 유도된 철 결핍성 빈혈흰쥐에서 참 당귀 열수추출물이 혈액학적 빈혈지표에 미치는 영향. 한국영양학회지. 2007 ; 40(5) : 428-434.
  7. 유은정, 김창환, 김용석, 박영배, 김형균, 강성길. 당귀(當歸) 약침 자극이 흰쥐의 난소기능에 미치는 영향. 대한침구학회지. 1998 ; 15(1) : 305-315.
  8. Brawer JR, Munoz M, Farookhi R. Development of the polycystic ovarian condition (PCO) in the estradiol valerate-treated rat. Biol Reprod. 1986 ; 35(3) : 647-655. https://doi.org/10.1095/biolreprod35.3.647
  9. Caillol M, Mondain-Monval M, Meunier M, Rossano B. Pituitary and ovarian responses to luteinizing-hormone-releasing hormone during pregnancy and after parturition in brown hares (Lepus europaeus). J Reprod Fertil. 1991 ; 92(1) : 89-97. https://doi.org/10.1530/jrf.0.0920089
  10. 주병주, 이동녕, 서일복, 김형준. 當歸芍藥散이 실험적으로 유발된 흰쥐의 자궁내막증의 발달 및 관련 cytokine 에 미치는 영향. 대한한방부인과학회지. 2008 ; 21(4) : 104-127.
  11. 문덕빈, 김미진, 엄윤경, 공복철, 이인선. 여고생 월경통에 대한 酒煮當歸丸의 효능에 관한 임상적 연구. 대한한방부인과학회지. 2005 ; 18(2) : 83-99.
  12. 유동렬. 임신유지에 활용되는 金櫃當歸散에 대한 연구. 대한한방부인과학회지. 1998 ; 11(2) : 135-164.
  13. 신용완, 이정은, 이보라, 신경숙, 정진홍, 유동렬. 加味當歸散을 투여한 임신병 환자 7例에 대한 임상보고. 대한한방부인과학회지. 2003 ; 16(4) : 180-188
  14. Manneras L, Cajander S, Holmang A, Seleskovic Z, Lystig T, Lonn M, Stener-Victorin E. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology. 2007 ; 148(8) : 3781-3791. https://doi.org/10.1210/en.2007-0168
  15. Farookhi R, Hemmings R, Brawer JR. Unilateral ovariectomy restores ovulatory cyclicity in rats with a polycystic ovarian condition. Biol Reprod. 1985 ; 32(3) : 530-540. https://doi.org/10.1095/biolreprod32.3.530
  16. Quirarte GL, Reid LD, de la Teja IS, Reid ML, Sanchez MA, Diaz-Trujillo A, Aguilar-Vazquez A, Prado-Alcala RA. Estradiol valerate and alcohol intake : dose-response assessments. BMC Pharmacol. 2007 ; 7 : 3.
  17. R. FAROOKHI, R. HEMMINGS, J. R. BRAWER. Unilateral Ovariectomy Restores Ovulatory Cyclicity in Rats with A Polycystic Ovarian Condition. BIOLOGY OF REPRODUCTION 1985 ; 32 : 530-540. https://doi.org/10.1095/biolreprod32.3.530
  18. JAMES R. BRAWER, MICHAEL MUNOZ, RIAZ FAROOKHI. Development of the Polycystic Ovarian Condition (PCO) in the Estradiol Valerate-Treated Rat. BIOLOGY OF REPRODUCTION 1986 ; 35 : 647-655. https://doi.org/10.1095/biolreprod35.3.647
  19. R. FAROOKHI, R. HEMMINGS, J. R. BRAWER. Unilateral Ovariectomy Restores Ovulatory Cyclicity in Rats with A Polycystic Ovarian Condition. BIOLOGY OF REPRODUCTION 1985 ; 32 : 530-540. https://doi.org/10.1095/biolreprod32.3.530
  20. 노재숙, 유중배, 조수현, 김학순, 황윤영. 다낭성 난소를 가진 여성에서 혈중 인슐린유사 성장인자와 결합단백질에 관한 연구. 대한산부인과학회지. 2000 ; 43(5) : 795-805.
  21. Rebar R, Judd HL, Yen SS, Rakoff J, Vandenberg G, Naftolin F. Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest 1976 ; 57 : 1320-29. https://doi.org/10.1172/JCI108400

Cited by

  1. 도홍사물탕(桃紅四物湯)이 골절 유합에 미치는 실험적 연구 vol.30, pp.2, 2011, https://doi.org/10.18325/jkmr.2020.30.2.47