The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on Corticotropin-Releasing Factor, c-Fos, and Tyrosine Hydroxylase in Forced Swimming Test

지골피(地骨皮)와 목단피(牧丹皮) 복합제(複合劑)가 강제수영부하실험에서 CRF, c-Fos와 Tyrosine Hydroxylase에 미치는 영향

  • Sim, Eun-Yeong (Formulae Pharmacology Dept. School of Oriental Medical School, Kyungwon University) ;
  • Lee, Tae-Hee (Formulae Pharmacology Dept. School of Oriental Medical School, Kyungwon University)
  • 심은영 (경원대학교 한의과대학 방제학교실) ;
  • 이태희 (경원대학교 한의과대학 방제학교실)
  • Received : 2011.04.26
  • Accepted : 2011.06.10
  • Published : 2011.06.30
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Abstract

Objectives : The goal of this study was to investigate the antidepressant effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on the change of HPA-Axis and Catecholamic system. Methods : We were performed the Forced Swimming Test. The expressions of Corticotropin-Releasing Factor (CRF) and c-Fos at paraventricular nucleus (PVN), and tyrosine hydroxylase (TH) at ventral tegmental area (VTA) and locus coeruleus (LC) were evaluated by immunohistochemical method. Results : The duration of immobility in the Forced Swimming Test was significantly decreased in A100, A400(p<0.05~p<0.01). CRF expressions at PVN was significantly decreased in A400(p<0.05).No other group showed significant difference in expression of c-Fos at PVN comparing with control group. TH expressions at VTA was significantly decreased in A100 and A400, respectively(p<0.001). TH expressions at LC was significantly decreased in A100(p<0.01). Conclusions : According to the above results, Mixture of Lycii Radicis Cortex and Moutan Cortex has antidepressant effects via the reduction of CRF expression and the Catecholamine System activity.

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References

  1. Mark J. Millan. Multi-target strategies for the improved treatment of depressiveststes:Conceptual foundations and neuronal substrates, drug discovery and therapeutic application 2005:141-143.
  2. Huh Joon. Supplemental Interpretation of Donguibo-Gam. Seoul:Namsan-Dang. 2000:35.
  3. Moon Jun-Jeon et al, Oriental Medicine Pathology. Seoul:Gomoon-Sa, 1990:199, 200.
  4. Jo Yong-Kook, Lee Tae-Hee. Anti-stress effects of Sihoueokgantang in the passive avoidance test and the forced swimming test. The Korean Journal of Oriental Medical Prescription. 2007:15(2);147-160.
  5. Shin Jae-Yong. Interpretation on the Bangyakhappyun. Seoul:Research Institute on the Traditional Medicine. 1988:321.
  6. Su Pei Gen et al. Illustrated Book of Chinese Medicinal Herbs. Vol 1. Hong Kong:The Commercial Press. 1988:170.
  7. The Concerted Publishing of the Korean National Herbology Professor. Herbology. Seoul:Yeong Lim Sa. 1994:193,194.
  8. Dong-Kyun Koh, Tae-Hee, Lee. Antistress effects of Lycii Radicis Cortex in the passive avoidance test and the forced swimming test. The Korea Journal of Herbology. 2007;22:137-146.
  9. Young-Suk Sung, Tae-Hee Lee. Effects of Moutan Cortex on Corticotropin-Releasing Factor, c-Fos and Tyrosine Hydroxylase in Forced Swimming Test. The Korean Journal of Oriental Medical Prescription. 2009;17(1):129-140.
  10. Tafet GE, Bernardini R. Psychoneuroendocrinological links between chronic stress and depression. Progress in neuro-Psychopharmacology & Biological Psychiatry. 2003;27:893-903. https://doi.org/10.1016/S0278-5846(03)00162-3
  11. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in rats : A new model sensitive to antidepressant treatments. European Journal of Pharmacology. 1978;47(4):379-391. https://doi.org/10.1016/0014-2999(78)90118-8
  12. Garcia G, Tagliaferro P, Ferri A, Evangelista de Duffard AM, Duffard R, Brusco A. Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2,4-dichlorophenoxyacetic Acid. Neurotoxicology. 2004;25:951-7. https://doi.org/10.1016/j.neuro.2004.05.004
  13. Paxinos G & Watson C. The Rat Brain in Stereotaxic Coordinates. 4th Edition. San Diego:Academic Press. 1998:26-27, 40-47, 56-62, 80-82, 95-100.
  14. Kim Hyun Jae, Hong Won Sik. Encyclopedia on Oriental Medicine. Seoul:Seong Bo Sa. 1988:228.
  15. The Korean National Liver and Billiary Medicinal Dept. Liver and Billiary Medicine. Seoul:Research Institute on the Oriental Medicine. 1989:44.
  16. Li Chan. Introduction to the Oriental Medicine. Seoul:Han Seong Sa. 1994:409, 534.
  17. Kim Hyun-Jun, Lee Tae-Hee. Effects of Shihoieokgan-Tang with Other Herbs and Formulae Pretreatment on the Change of Corticoterone Induced by Immobilization Stress in Mice. The Korean Journal of Oriental Medical Prescription. 2002;10(2):57-72.
  18. Ahn, Su-jin, Lee Tae-Hee. Effect of Chaihushugansan and Chaihuyigantang on the change of Monoamine Contents in the Hypothalamus of Mice induced by the Immobilization Stress. The Korean Journal of Oriental Medical Prescription. 2003;11(1):99-114.
  19. Beom-Mo Koo, Tae-Hee Lee. Effects of Lycii Radicis Cortex in HPA -Axis System on the Forced Swimming Test. The Korean Journal of Oriental Medical Prescription. 2010;18(2):215-225.
  20. Seong Rak Ki, Kim Seong Hoon, Seo Young Bae, Oh Ahn Hyang. Effect of Lycii Radicis Cortex and Lycii Ramulus Cortex on the level of serum glucose, anti-pyresis, blood pressure and the change of hematologic change. Journal of Herbology. 1994;9(1):161-171.
  21. Kim Dong Hyuk, Song Bong Geun, Kim Hyung Gyun. Effect of Moutan Cortex on the Arthritis induced by Collagen. Journal of Korean Traditional Medicine. 1997;7(2):60-69.
  22. Yong-Ki Park, Ji-Young Min, Je-Hyun Lee. The Effect of Methyl Gallate Isolated from Paeonia suffruticosa on Inflammatory Response in LPS-stimulated RAW264.7 Cells. Korean Journal of Herbology. 2009;24(4):181-188.
  23. Chrousos GP, Loriaux DL, Gold PW. Mechanisms of physical and emotional stress. Plenum, New York. 1988:245.
  24. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. JAMA. 1992;267:1244-1252. https://doi.org/10.1001/jama.1992.03480090092034
  25. Min Seong Kil. Current Psychiatry. Seoul:Il Jo Gak. 1996:14, 201-205, 111.
  26. Eduardo E. Benarroch. Paraventricular nucleus, stress response, and cardiovascular disease. Clin Auton Res. 2005;15:254-63. https://doi.org/10.1007/s10286-005-0290-7
  27. Olschowka JA, O'Donohue TL, Mueller GP, Jacobowitz DM. Hypothalamic and extrahypothalamic distribution of CRF-like immunoreactive neurons in the rat brain. Neuroendocrinology. 1982;35:305-8. https://doi.org/10.1159/000123398
  28. Nemeroff CB, Widerlov E, Bissette G, et al. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science. 1984;226:1342-4. https://doi.org/10.1126/science.6334362
  29. Doucet JP, Squinto SP, Bazan NG. Fos-jun and the primary genomic response in the nervous system. Mol. Neurobiol. 1990;4:27-55. https://doi.org/10.1007/BF02935584
  30. Komori T, Nomura J, Inoue K, Kitayama I. Tyrosine hydroxylase activity in discrete brain regions of depression model rats. Jpn J Psychiatry Neurol. 1990;44:747-54.
  31. Beitner-Johnson D, Guitart X, Nestler EJ. Neurofilament proteins and the mesolimbic dopamine system: common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area. J. Neurosci. 1992;12:2165-76.
  32. Miller WR. Psychological deficit in depression. Psychol. Bull. 1975;82:238-60. https://doi.org/10.1037/h0076367
  33. Cross AR, Neary D. Neuroanatomy. New York:Churchill Living-stone. 1996:65-69, 121-2.
  34. Danial SM, Amer Karmal, Marten PS, Geert MJ. Modulation of cellular activity and synaptic transmission in the Ventral Tegmental Area. European Journal of Pharmacology 2003;480:97-115. https://doi.org/10.1016/j.ejphar.2003.08.097
  35. Mark A, Smith, M. S., Altemus, M., Michelson, D., Hong, S., Kvetnanskyi, R. & Post, R. Stress and antidepressants differentially regulate neurotrophin 3mRAN expression in the locus coeruleus. Neurobiology. 1995;8788-92.