Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Comparison of the Anti-inflammatory Effects of Water Fermented and Ethanol Fermented Extracts from Rhei Radix et Rhizoma

물추출 발효대황과 에탄올추출 발효대황의 항염증 효과에 관한 비교

  • Kim, Nan-Young (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Hae-Ja (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Joo-Hee (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Eun-Kyoung (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Ok-Hwa (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • So, Hong-Seob (Department of Microbiology, School of Medicine, Wonkwang University) ;
  • Lee, Ki-Nam (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Chong, Myong-Soo (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
  • 김난영 (원광대학교 한의학전문대학원 제3의학과) ;
  • 김혜자 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이주희 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이은경 (원광대학교 한의과대학 예방의학교실) ;
  • 강옥화 (원광대학교 약학대학 한약학과) ;
  • 권동렬 (원광대학교 약학대학 한약학과) ;
  • 소홍섭 (원광대학교 의과대학 미생물학교실) ;
  • 이기남 (원광대학교 한의과대학 예방의학교실) ;
  • 정명수 (원광대학교 한의과대학 예방의학교실)
  • Received : 2011.01.26
  • Accepted : 2011.03.17
  • Published : 2011.04.25
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Abstract

Water Fermented and Ethanol Fermented Extracts from Rhei Radix et Rhizoma exhibit potent anti-inflammatory activity with an unknown mechanism. To elucidate the molecular mechanisms of W-FR and E-FR on pharmacological and biochemical actions in inflammation, we examined the effect of W-FR and E-FR on pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated macrophages. The investigation focused on whether FR inhibited nitric oxide (NO), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-6 (IL-6) and the expressions of iNOS, COX-2 in LPS-stimulated RAW 264.7 cells. We found that FR inhibited LPS-induced NO, TNF-${\alpha}$ and IL-6 productions as well as the expressions of iNOS and COX-2. These results suggest that W-FR and E-FR have inhibitory effects on LPS-induced TNF-${\alpha}$, NO, and IL-6 production, as well as the expressions of iNOS and COX-2 in the murine macrophage.

Keywords

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