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Antibacterial Activity of $Scutellaria$ $baicalensis$ Extract against Antibiotic Resistant Bacteria

항생제 내성균에 대한 황금 추출물의 항균효과

  • Jang, Jae-Seon (Dept. of Food & Nutrition, Gachon University of Medicine & Science) ;
  • Kim, Jung-Hee (Health and Environment Research Institute) ;
  • Kwon, Mun-Ju (Health and Environment Research Institute)
  • 장재선 (가천의과학대학교 식품영양학과) ;
  • 김정희 (인천시 보건환경연구원) ;
  • 권문주 (인천시 보건환경연구원)
  • Received : 2011.11.12
  • Accepted : 2011.12.06
  • Published : 2011.12.31

Abstract

This study was focused on the determination of antibacterial activity of $Scutellaria$ $baicalensis$ extract against antibiotic resistant bacteria($Salmonella$ Enteritidis, $Staphylococcus$ $aureus$ and enteroaggregative $E.$ $coli$). Extract of $Scutellaria$ $baicalensis$ were tested for antibacterial activity by paper disc methods. The $Scutellaria$ $baicalensis$ extract in 0.1 g/$m{\ell}$ and 0.2 g/$m{\ell}$ showed a significant antibacterial activity against antibiotic resistant bacteria. Minimum inhibitory concentration (MIC) of $Scutellaria$ $baicalensis$ extract were appeared to 2,048 ${\mu}g/m{\ell}$ at $S.$ Enteritidis, $S.$ $aureus$ and enteroaggregative $E.$ $coli$. Finally, the growth incubation curve was determined using $Scutellaria$ $baicalensis$ extract against $S.$ Enteritidis, $S.$ $aureus$ and enteroaggregative $E.$ $coli$. The growth of $S.$ Enteritidis was significantly inhibited within 10 hours by the addition of at least 10,000 ppm of $Scutellaria$ $baicalensis$ extract. The 10,000 ppm of $Scutellaria$ $baicalensis$ extract retarded the growth of $S.$ $aureus$ and enteroaggregative $E.$ $coli$ more than 10 hours. In conclusion, $Scutellaria$ $baicalensis$ extract might be useful to control antibiotic resistant bacteria $in$ $vitro$.

Keywords

References

  1. Abo KA, Ogunleye VO, Ashdi JS. 1999. Antimicrobial potential of Spondias monbin, Croton zambesicus and Zygotritonia crocea. Phytother Res 13:494-497 https://doi.org/10.1002/(SICI)1099-1573(199909)13:6<494::AID-PTR490>3.0.CO;2-9
  2. Bae JH, Lee MJ, Lee SM. 2005. Antimicrobial effect of Scutellaria baicalensis Georgi extracts on food-borne pathogens. J Kor Microbiol Biotechnol 33:35-40
  3. Brassart D, Schiffrin EJ. 1997. The use of probiotics tod reinforce mucosal defence mechanisms. Trends Food Sci Technol 8:321-326 https://doi.org/10.1016/S0924-2244(97)01071-6
  4. Chattopadhyay D, Maiti K, Kundu AP, Chakraborty MS, Bhadra R, Mandal SC, Mandal AB. Antimicrobial activity of Alstonia macrephylla: A folklore of bay islands. J Ethnopharmacol 77:49-55
  5. Cho SH, Kim YR. 2001. Antimicrobial characteristics of Scutellariae Radix extract. J Kor Soc Food Sci Nutr 30:964-968
  6. Choi EM, Lee BK, Koo SJ. 2001. Inhibitory effect on delayed type hypersensitive by the hot water extracts from medicinal herbs. Kor J Food Sci Technol 33:146-148
  7. Choi MR, Lee JS, Lim HS. 2007. Changes in physiological activities of Scutellariae baicalensis by heating. J Life Sci 17:1381-1386 https://doi.org/10.5352/JLS.2007.17.10.1381
  8. Cutter CN. 2000. Antimicrobial effect of herb extracts against E. coli O157:H7, Listeria monocytogenes, and Salmonella typhimurium associated with beef. J Food Prot 63:601-607 https://doi.org/10.4315/0362-028X-63.5.601
  9. Gurrieri S, Schaafsma GJ. 1998. Probiotics. Int J Food Microbiol 39:237-238 https://doi.org/10.1016/S0168-1605(97)00136-0
  10. Jung EA, Kim NJ, Kim YG, Kim DH, Lee SI. 2001. Studies on the development of antihyperlipidemic drugs from oriental herbal medicines(III)-Antihyperlipidemic effects of Gamigwaruhaebaekwhanggum- Tang and its constituent herbal medicines in vitro. Kor J Pharmacogn 32:22-30
  11. Jung JW, Ahn NY, Park SH, Oh JG, Oh HR, Lee BG, Om AS, Kim BS, Kim DH, Ryu JH. 2004. The anxiolytic-like effects of Scutellaria baicalensis using elevated plus-maze in rats. Kor J Pharm 35:22-27
  12. Kim CH, Jia H, Kim SH, Moon HJ, Lee JS. 2004. The protective effect of Scutellaria baicalensis Georgi on ischemiareperfusion injuries of rat hearts. Kor J Lab Ani Sci 20:357-362
  13. Kim SC, Ahn KS, Park CK, Jeon BS, Lee JT, Park WJ. 2006. Isolation of antioxidative compound from Scutellaria baicalensis G. J Kor Medicinal Crop Sci 14:212-216
  14. Kim YE, Lee YC, Kim HG, Kim CJ. 1997. Antioxidative effect of ethanol fraction for several Korean medicinal plant hot water extracts. Kor J Food & Nutr 10:141-144
  15. Kim YH, Park YS. 2006. Effect of Scutellaria baicalensis water extract on antioxidative activity and epidermal thickness in DNCB-induced allergic contact dermatitis animal model. J Kor Soc Food Sci Nutr 35:543-548 https://doi.org/10.3746/jkfn.2006.35.5.543
  16. Kwon NH, Kin SH, Bae WK, Kim JY, Lim JY, Noh KM, Kim JM, Ahn JS, Hur J, Park YH. 2001. Antimicrobiol activity of Lactobacillus reuteri against Bacillus anthracis sterne 34 F2. Kor J Vet Publ Hlth 25:277-287
  17. Kwon NH, Kin SH, Bae WK, Kim JY, Lim JY, Noh KM, Kim JM, Ahn JS, Hur J, Park YH. 2001. Antimicrobiol activity of Lactobacillus reuteri against major food-borne pathgens. J Food Hyg Safety 16:264-273
  18. Lee CK, Seo JJ. 2005. Antimicrobial activity of Whangkumtang extract and Scutellariae radix extract on the food-borne pathogens. J Kor Soc Food Sci Nutr 34:1606-1610 https://doi.org/10.3746/jkfn.2005.34.10.1606
  19. Mah MW, Menish ZA. 2000. Antibiotic resistance. An impending cirsis. Saudi Med J 21:1125-1129
  20. Moon YH, Lee YH, Min BS, Bae KH. 1997. Antibacterial constituents from Scutellariae radix against Streptococcous mutans OMZ176. J Kor Pharmacogn 28:99-103
  21. Neu HC. 1992. The crisis in antibiotic resistance. Science 257: 1064-1073 https://doi.org/10.1126/science.257.5073.1064
  22. Park SN, Hong JH, Park MG. 1997. Biological protective effect of component from Scutellaria baicalensis Georgi against active oxygen induced-tissue damage(V). Research Bulletin of Seoul-Agriculture University 45:189-199
  23. Potera C. 2001. Tree extract curbs food-borne pathogen. ASM News 67:605-606
  24. Rhee JS, Woo ER, Kim NH, Lee EJ, An DK, Lee JH, Park SK, Park HK. 1997. A study on qualitative and quantitative analysis of major ingredients in Scutellariae radix. Anal Sci Technol 10:91-104
  25. Ro HS, Ko WG, Kim OJ, Park KK, Cho YW, Park HS. 1996. Antihyperlipidemic activity of Scutellaric baicalensis Georgi, Coptidis japonica Makino and Rhei koreanum on externental hyperlipidemic in rats. J Kor Pharm 26:215-219
  26. Woo IT, Park KN, Lee SH. 2007. Antimicrobial activities of Scutellaria baicalensis Georgi against various pathogens and spoilage bacteria isolated from Tofu. J Kor Soc Food Sci Nutr 36:470-475 https://doi.org/10.3746/jkfn.2007.36.4.470
  27. Yang JH, Kim YI. 1998. Preparation and antibacterial effects of Scutellariae radix extract emulsion containing baicalin. J Kor Pharm Sci 28:159-164

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