Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Effect of Cnidium officinale Extract on Recovery Capability of Allergic Contact-Dermatitis in Rat

흰쥐의 알레르기성 접촉피부염의 회복에 미치는 천궁추출물의 영향

  • Lim, Jae-Hwan (Department of Biological Science, Andong National University) ;
  • Park, Young-Mi (Department of Biological Science, Andong National University) ;
  • Kim, Jeong-Sook (Department of Biological Science, Andong National University) ;
  • Jeong, Hyung-Jin (Department of Medicinal Plant Resource, Andong National University) ;
  • Seo, Eul-Won (Department of Biological Science, Andong National University)
  • 임재환 (안동대학교 자연과학대학 생명과학과) ;
  • 박영미 (안동대학교 자연과학대학 생명과학과) ;
  • 김정숙 (안동대학교 자연과학대학 생명과학과) ;
  • 정형진 (안동대학교 자연과학대학 생약자원학과) ;
  • 서을원 (안동대학교 자연과학대학 생명과학과)
  • Received : 2011.02.14
  • Accepted : 2011.06.27
  • Published : 2011.08.31
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Abstract

The epidermal recovering-effects of the Cnidium officinale extract after inducing contact-dermatitis by 1-chloro-2,4-dinitrochlorobenzene (DNCB) showed by measuring thickness of skin, identifying IgE amounts in plasma, and activities of anti-oxidant enzymes using histochemical and biochemical methods. By three-time applications of the extract, morphological changes of dermatitis in impaired region were recovered dramatically and shape of skin surface and thickness of epidermis were restored to be normal. Also, lipid content was recovered to the level of normal state. We suggested that extract treatment lowered a hypersensitive reaction by decreasing of IgE level in blood and restored activities of superoxide dismutase and catalase. In conclusion, we proposed that C. officinale extract might be used as natural resources for treating effectively allergic contact-dermatitis.

본 연구에서는 DNCB에 의해 인위적으로 접촉피부염을 유발시킨 후 천궁추출물을 표피에 처리하여 피부표면, 피부두께, 혈장내 성분, 혈장내 IgE 농도 및 항산화효소을 조사하여 표피의 회복능에 미치는 효과를 조사하였다. 천궁추출물은 DNCB에 의해 유발된 알레르기성 접촉피부염에 도포 시에 환부의 피부염이 급격히 호전되었으며, 피부표면은 정상군에 비교될 정도로 각질이 없어진 깨끗하고 매끄러운 상태로 되었으며, 표피층의 두께도 점차 정상군과 같은 상태로 회복되고 있는 것으로 관찰되었다. 또한 알레르기성 접촉피부염이 유발되어 체내 지질함량이 급격히 증가된 경우 지질함량을 낮춰 정상수준으로 회복시키는 지질함량의 개선에 효과적으로 작용하고 있으며, 직접적으로 혈액 내 IgE 수준의 감소에 관여하여 피부의 과민반응 해소에 관여할 것으로 생각된다. SOD와 catalase의 활성은 천궁추출물의 처리에 의해 정상군 수준으로 낮아지는 경향을 보이고 있어 항산화 효소의 활성을 낮춰 정상수준으로 회복시켜주는 효과를 갖는 것으로 생각된다. 결론적으로 천궁 추출물은 알레르기성 접촉피부염의 회복에 매우 효과적으로 작용하는 천연 유용자원으로 이용할 수 있을 것으로 생각된다.

Keywords

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