Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Acute Toxicity of a Combined Preparation of the Standardized Extracts of Scutellaria baicalensis GEORGI and Salvia miltiorrhiza BUNGE

황금 및 단삼 표준화시료의 급성독성에 관한 연구

  • Chang, Bo-Yoon (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Malla, Bindu (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Sohn, Dong-Hwan (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Yoon-Chul (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Sung-Yeon (Unstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
  • 장보윤 (원광대학교 약학대학 약품연구소) ;
  • 빈두말라 (원광대학교 약학대학 약품연구소) ;
  • 손동환 (원광대학교 약학대학 약품연구소) ;
  • 김윤철 (원광대학교 약학대학 약품연구소) ;
  • 김성연 (원광대학교 약학대학 약품연구소)
  • Received : 2011.07.29
  • Accepted : 2011.09.23
  • Published : 2011.09.30
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Abstract

Acute toxicity of a combined preparation of the standardized extracts Scutellaria baicalensis GEORGI and Salvia miltiorrhiza BUNGE in a ratio of 3:1 was examined in male and female ICR mice. Mice were treated with the test substance intragastrically at a dose of 0 mg/kg, 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. No death or abnormal clinical sign was shown during the observation period. Also there were no difference in net body weight gain, organ weight, and gross pathological findings at the terminal sacrifice. The results suggested that acute oral toxicity of a combined preparation of the standardized extracts is very low at the conditions employed in this study.

Keywords

References

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