Journal of Animal Science and Technology

Korean Society of Animal Sciences and Technology (한국축산학회)
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Effect of the Fatty Acid Synthase and Acetyl CoA Carboxylase Genes on Carcass Quality in Commercial Hanwoo Population

한우의 Fatty Acid Synthase (FASN)와 Acetyl CoA Carboxylase-α (ACACA) 유전자내의 단일염기변이가 한우집단내의 도체형질에 미치는 영향

  • Jeon, Eun-Kyeong (Department of Animal Science, Chungbuk National University) ;
  • Kim, Sang-Wook (Department of Animal Science, Chungbuk National University) ;
  • Choi, Yun-Jeong (Department of Animal Science, Chungbuk National University) ;
  • Kim, Nae-Soo (Department of Animal Science, Chungbuk National University) ;
  • Cho, Man-Weuk (NongHyup Livestock Research Center) ;
  • Lee, Myoung-Il (NongHyup Livestock Research Center) ;
  • Jeong, Yong-Ho (Korean Animal Improvement Association, Hanwoo Improvement Division) ;
  • Lee, Jin-Suk (Korea Institute for Animal Products Quality Evaluation.) ;
  • Kim, Kwan-Tae (Korea Institute for Animal Products Quality Evaluation.) ;
  • Koh, Kyung-Chul (Korea Institute for Animal Products Quality Evaluation.) ;
  • Kim, Kwan-Suk (Department of Animal Science, Chungbuk National University)
  • 전은경 (충북대학교 농업생명환경대학 축산학과) ;
  • 김상욱 (충북대학교 농업생명환경대학 축산학과) ;
  • 최윤정 (충북대학교 농업생명환경대학 축산학과) ;
  • 김내수 (충북대학교 농업생명환경대학 축산학과) ;
  • 조만욱 (농협중앙회 축산연구원) ;
  • 이명일 (농협중앙회 축산연구원) ;
  • 정용호 (한국종축개량협회 한우개량부) ;
  • 이진석 (축산물품질평가원) ;
  • 김관태 (축산물품질평가원) ;
  • 고경철 (축산물품질평가원) ;
  • 김관석 (충북대학교 농업생명환경대학 축산학과)
  • Received : 2011.08.03
  • Accepted : 2011.09.30
  • Published : 2011.10.31
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Abstract

This study was conducted to investigate the combined effect of fatty acid synthase (FASN) and Acetyl CoA Carboxylase-${\alpha}$ (ACACA) genes on carcass traits of Korean cattle (Hanwoo). A total of 1,057 commercial Hanwoo cattle provided by the NongHyup Livestock Research Center (NLRC) and Hanwoo Performance Competition (HPC) were used to analyze the effect of four single nucleotide polymorphisms (SNPs) within FASN (g.11280A>G, g.16024A>G, g.16039T>C, and g.17924A>G) and one SNP within ACACA (g.2274G>A) genes. In addition, the effect of genotypic combinations between FASN (g.17924A>G) and ACACA (g.2274G>A) SNPs has been studied with carcass traits. Significant associations were identified between g.17924A>G of FASN and carcass weight and back fat, and between the ACACA gene SNP g.2274G>A and longissimus muscle area with HPC samples. It was also found that both effects of FASN g.17924A>G and ACACA g.2274G>A polymorphisms were consistent in NLRC samples. Combined analyses of both NLRC and HPC samples also revealed the significant associations between the FASN g.17924A>G and carcass weight and back fat and between the ACACA g.2274G>A and back fat, respectively. The effect of the genotypic combination of g.17924A>G within FASN and g.2274G>A within ACACA genes showed that the combination of both GG genotypes of FASN and ACACA SNPs causes higher carcass weight and marbling score. The results of this study indicate that the two SNP markers within the FASN and ACACA genes can be utilized to select superior Hanwoo cows and calves in commercial Hanwoo farms.

본 연구는 지방산의 합성의 완성 및 지방세포의 성장 및 합성에 영향을 미치는 FASN과 ACACA 유전자내의 단일염기변이(SNP)들을 한우의 도체형질에 미치는 영향을 조사하기 위해 수행되었다. 한우 능력평가집단 425두와 농협 축산연구원에서 제공받은 632두를 대상으로 FASN 유전자내의 4개(g.11280A>G, g.16024A>G, g.16039T>C, g.17924A>G)의 단일염기변이들과 ACACA 유전자내의 1개(g.2274G>A) 단일염기변이들이 도체형질에 미치는 효과를 분석하였다. 한우능력평가집단에서 FASN g.17924A>G는 도체중과 등지방두께에 유의적인 연관성을 나타내었으며, ACACA g.2274G>A는 배장근 단면적에 유의적인 연관성을 나타내었다. 농협 축산연구원의 샘플에서도 FASN g.17924A>G는 도체중에서 ACACA g.2274G>A는 배장근 단면적에서 동일한 유의적인 연관성이 관찰되었다. 한우 능력평가집단과 농협 축산연구원 샘플을 통합하여 FASN 유전자 g.17924A>G 와 ACACA 유전자 g.2274G>A 변이를 분석한 결과에서는 FASN g.17924A>G는 도체중과 등지방두께에 유의적인 연관성이 나타났으며, ACACA g.2274G>A는 등지방두께에서 유의적인 연관성을 나타내었다. 또한 FASN g.17924A>G와 ACACA g.2274G>A 의 유전자형조합에 따른 분석에서 도체중과 근내지방도에서 상호작용효과가 추정되었으며, 도체중과 근내지방도에 유의적인 상가적 효과를 나타내었다. FASN g.17924G>A의 GG 유전자형과 ACACA g.2274A>G의 GG 유전자형의 조합을 가진 개체는 다른 유전자형 조합을 가진 개체보다 높은 도체중과 근내지방도를 발현하는 개체인 것으로 관찰되었다(P<0.05). 본 연구의 결과는 두 유전자내의 단일염기변이들을 육량과 육질이 우수한 송아지 생산에 활용될 수 있을 것으로 사료된다.

Keywords

References

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