Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Prognostic Significance of GSTP1, XRCC1 and XRCC3 Polymorphisms in Non-small Cell Lung Cancer Patients

  • Ke, Hong-Gang (Department of Cardiovascular Surgery, the First Affiliated Hospital of Soochow University) ;
  • Li, Jun (Department of Respiratory Medicine, the Affiliated Hospital of Nantong University) ;
  • Shen, Yi (Department of Statistical Research, Nantong University) ;
  • You, Qing-Sheng (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University) ;
  • Yan, Yu (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University) ;
  • Dong, Han-Xuan (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University) ;
  • Liu, Jun-Hua (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University) ;
  • Shen, Zhen-Ya (Department of Cardiovascular Surgery, the First Affiliated Hospital of Soochow University)
  • Published : 2012.09.30
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Abstract

Aim: Individual differences in chemosensitivity and clinical outcome in non-small cell lung cancer (NSCLC) patients treatment with platinum-based chemotherapy may be due to genetic factors. Our study aimed to investigate the prognostic role of GSTP1, XRCC1 and XRCC3 in NSCLC patients treated with chemotherapy. Methods: A total of 460 cases were consecutively selected from The Affiliated Hospital of Nantong University between Jan. 2003 to Nov. 2006, and all were followed-up until Nov. 2011. Genotyping of GSTP1 Ile105Val, XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met was conducted by duplex polymerase-chain-reaction with confronting-two-pair primer methods. Results: Patients with GSTP Val/Val exhibited a shorter survival time, and had a 1.89 fold greater risk of death than did those with the IIe/IIe genotype. For XRCC1 Arg194Trp, the variant genotype Trp/Trp was significantly associated with a decreased risk of death from NSCLC when compared with the Arg/Arg. Individuals carrying XRCC1 399Gln/Gln genotype had a longer survival time, with a lowered risk of death from NSCLC. Conclusion: This study indicated that GSTP1 Ile105Val, XRCC1 Arg194Trp and XRCC1Arg399Gln genes have a role in modifying the effect of platinum-based chemotherapy for NSCLC patients in a Chinese population. Our findings provide information for therapeutic decisions for individualized therapy in NSCLC cases.

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