Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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In-vitro and in-vivo Behaviors of Poly(glycolide-caprolactone) Copolymer for Bioabsorbable Suture Materials

  • Yoo, Yeon-Chun (Department of Textile Engineering, Chonbuk National University) ;
  • Kim, Hak-Yong (Department of Textile Engineering, Chonbuk National University) ;
  • Jin, Fan-Long (School of Chemical and Materials Engineering, Jilin Institute of Chemical Technology) ;
  • Park, Soo-Jin (Department of Chemistry, Inha University)
  • Received : 2012.07.26
  • Accepted : 2012.09.28
  • Published : 2012.12.20
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Abstract

A novel bioabsorbable suture material, poly(glycolide-caprolactone) (PGLCL) monofilament, was prepared by spinning of the PGLCL copolymer. The physical properties, strength retention, biocompatibility, and organism resolvability of the PGLCL monofilament were investigated. The results showed that the knot pull strength of the monofilament was higher than that stated in European Pharmacopoeia. The in vivo retention strength following implantation was 64%, 23%, 7%, and 0% after one, two, three, and four weeks, respectively. Mortality, clinical signs, validation, and sterility tests indicated that all items had passed. Organism resolvability tests showed that the PGLCL monofilament, as a suture, was absorbed within 91 days.

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