Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema

  • Ahn, Mi Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Han, Jea Woong (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Yoon, Hyung Joo (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Hwang, Jae Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Yun, Eun Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
  • Received : 2012.08.30
  • Accepted : 2012.11.26
  • Published : 2012.12.31
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Abstract

In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.

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References

  1. Ahn, M.Y., Han, J.W., Yoon, H.J., Park, H.C. and Chung, W.T. (2009). Single oral dose toxicity study of an alcohol extract of bumblebee, Bombus ignitus larvae in rats. Toxicol. Res., 25, 107-111. https://doi.org/10.5487/TR.2009.25.2.107
  2. Hansson, G.K. (2005). Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med., 352, 1685-1695. https://doi.org/10.1056/NEJMra043430
  3. Hussain, S.P., He, P., Subleski, J., Hofseth, L.J., Trivers, G.E., Mechanic, L., Hofseth, A.B., Bernard, M., Schwank, J., Nguyen, G., Mathe, E., Djurickovic, D., Haines, D., Weiss, J., Back, T., Gruys, E., Laubach, V.E., Wiltrout, R.H. and Harris, C.C. (2008). Nitric oxide is a key component in inflammationaccelerated tumorigenesis. Cancer Res., 68, 7130-7136. https://doi.org/10.1158/0008-5472.CAN-08-0410
  4. Kim, I., Lee, H.S., Kim, J.W., Yang, B.K., Ahn, M.Y., Kim, D.H. and Ryu, K.S. (2001). Variation of mineral compositions in the regional, varietal, and seasonal mulberry leaves. Int. J. Indust. Entomol., 2, 27-35.
  5. Meda, A., Lamien, C.E., Milogo, J., Romoto, M. and Nacoulma, O.G. (2004). Therapeutic uses of honey and honey bee larvae in central Burkian Faso. J. Ethanopharmacol., 95, 103-107. https://doi.org/10.1016/j.jep.2004.06.016
  6. Nussler, A.K. and Billiar, T.R. (1993). Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukocyte Biol., 54, 171-178.
  7. Reid, R.C. (2005). Inhibitors of secretory phospholipase A2 group IIA. Curr. Med. Chem., 12, 3011-3026. https://doi.org/10.2174/092986705774462860
  8. Schoenberg, M.H., Mayer, J.M. and Beger, H.G. (1997). [Phospholipase $A_{2}$--from basic research to clinical reality]. Chirurg, 68, 1112-1118. https://doi.org/10.1007/s001040050330
  9. Williams, K.R., Neice, R.L., Aterton, D., Fowler, A.V., Kutny, R. and Smith, A.J. (1988). The size, operation and technical capabilities of protein and nucleic acid core facilities. FASEB J., 2, 3124-3130. https://doi.org/10.1096/fasebj.2.15.3192042

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