The Korean Journal of Gastroenterology (대한소화기학회지)

The Korean Society of Gastroenterology (대한소화기학회)
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Obesity and Pancreatic Diseases

비만과 췌장질환

  • Kim, Ho-Gak (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Han, Ji-Min (Department of Internal Medicine, Catholic University of Daegu School of Medicine)
  • 김호각 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 한지민 (대구가톨릭대학교 의과대학 내과학교실)
  • Published : 2012.01.25
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Abstract

Obesity is defined as BMI (calculated as weight in kg divided by height in $m^2$) more than 30, and overweight is defined as BMI of 25-29.9. Obesity has been considered as a risk factor for pancreatic diseases, including pancreatitis and pancreatic cancer. Severe acute pancreatitis is significantly more frequent in obese patients. Furthermore, obese patients develop systemic and local complications of acute pancreatitis more frequently. The underlying mechanisms are increased inflammation and necrosis from increased amount of intra- and peri-pancreatic fat. In addition, obesity is a poor prognostic factor in acute pancreatitis, and overweight before disease onset appears to be a risk factor for chronic pancreatitis. Overweight and/or obesity are associated with greater risk of pancreatic cancer and younger age of onset. Physical activity appears to decrease the risk of pancreatic cancer, especially among those who are overweight. Long-standing diabetes increases the risk of pancreatic cancer. The pathogenic mechanism is that obesity and physical inactivity increase insulin resistance. In a state of hypersinulinemia, increased circulating level of insulin-like growth factor-1 induces cellular proliferation of pancreatic cancer. Obesity is associated with negative prognostic factor and increased mortality in pancreatic cancer. However, there are controversies regarding the effects of obesity on long-term post-operative results in the patient with pancreatic cancer.

Keywords

References

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