Journal of Industrial and Engineering Chemistry

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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In vitro skin permeation and cellular protective effects of flavonoids isolated from Suaeda asparagoides extracts

  • Park, Soo Nam (Department of Fine Chemistry, College of Nature and Life Science, Seoul National University of Science and Technology) ;
  • Kim, Sun Young (Department of Fine Chemistry, College of Nature and Life Science, Seoul National University of Science and Technology) ;
  • Lim, Gyu Nam (Department of Fine Chemistry, College of Nature and Life Science, Seoul National University of Science and Technology) ;
  • Jo, Na Rae (Department of Fine Chemistry, College of Nature and Life Science, Seoul National University of Science and Technology) ;
  • Lee, Min Hye (Department of Fine Chemistry, College of Nature and Life Science, Seoul National University of Science and Technology)
  • Published : 2012.03.25
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Abstract

The objective of this study was to compare astragalin (kaempferol-3-O-glucoside) isolated from Suaeda asparagoides extract with kaempferol, an aglycone of astragalin showing the anti-oxidative activity, the cellular protective effect, and skin permeability. Kaempferol was superior to (+)-${\alpha}$-tocopherol and Lascorbic acid known as strong antioxidants in the antioxidative activity by DPPH method and chemiluminescence assay. Astragalin and kaempferol exhibited more prominent cellular protective effect than the lipid peroxidation chain blocker, (+)-${\alpha}$-tocopherol. In this in vitro permeation experiment of astragalin and kaempferol through the ICR mouse skin, kaempferol permeated deeper into the skin than astragalin. These results indicate that kaempferol and astragalin can function as antioxidants in biological systems, particularly skin exposed to solar radiation, and protect cellular membranes against reactive oxygen species.

Keywords

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