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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction

  • Jung, In-Duk (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Kim, Hye-Young (Department of Pediatrics, Pusan National University Hospital) ;
  • Park, Jin-Wook (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Lee, Chang-Min (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Noh, Kyung-Tae (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Kang, Hyun-Kyu (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Heo, Deok-Rim (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Lee, Su-Jung (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Son, Kwang-Hee (Department of Microbiology and Immunology, School of Medicine, Pusan National University) ;
  • Park, Hee-Ju (Department of Pediatrics, Pusan National University Hospital) ;
  • Shin, Sung-Jae (Department of Microbiology, College of Medicine, Chungnam National University) ;
  • Park, Jong-Hwan (Department of Biochemistry, College of Medicine, Konyang University) ;
  • Ryu, Seung-Wook (Cell Signaling and Bioimaging Laboratory, Department of Bio and Brain Engineering, KAIST) ;
  • Park, Yeong-Min (Department of Microbiology and Immunology, School of Medicine, Pusan National University)
  • Received : 2012.01.16
  • Accepted : 2012.01.17
  • Published : 2012.02.29
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Abstract

In asthma, T helper 2 (TH2)-type cytokines such as interleukin (IL)-4, IL-5, and IL-13 are produced by activated $CD^{4+}$ T cells. Dendritic cells played an important role in determining the fate of naive T cells into either $T_H1$ or $T_H2$ cells. We determined whether RG-II regulates the $T_H1/T_H2$ immune response by using an ovalbumin-induced murine model of asthma. RG-II reduced IL-4 production but increased interferon-gamma production, and inhibited GATA-3 gene expression. RG-II also inhibited asthmatic reactions including an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyperresponsiveness. This study provides evidence that RG-II plays a critical role in ameliorating the pathogenic process of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of RG-II in terms of its effects in a murine model of asthma.

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