Food Science of Animal Resources (한국축산식품학회지)

Korean Society for Food Science of Animal Resources (한국축산식품학회)
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Effects of Bifidus Enhancer Yogurt on Relief from Loperamide-induced Constipation

  • Choi, Jin-Hee (Department of Food and Nutrition, Sookmyung Women's University) ;
  • Jeong, Seung-Hwan (Research & Development Center, Namyang Dairy Products Co., Ltd.) ;
  • Cho, Young-Hoon (Research & Development Center, Namyang Dairy Products Co., Ltd.) ;
  • Cho, Yun-Kyung (Research & Development Center, Namyang Dairy Products Co., Ltd.) ;
  • Choi, Hae-Yeon (Department of Home Economics Education, Kongju National University) ;
  • Kim, Sun-Im (Department of Food and Nutrition, Sookmyung Women's University)
  • Received : 2011.09.30
  • Accepted : 2011.12.29
  • Published : 2012.02.29
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Abstract

This study investigated the effects of bifidus enhancer yogurt (BEY) on loperamide-induced constipation in rats. The bifidus enhancer, made of rice-DDGS (Dried Distillers Grains with Solubles), improved proliferation of bifidobacteria (BB-12). Male SD rats were induced with constipation using loperamide and were then used to test the effectiveness of BEY in relieving constipation. The rats were divided into four groups: normal group (NOR), loperamide-treated group (LOP), bifidus enhancer yogurt and loperamide-treated group (L-BEY), and commercial yogurt and loperamide-treated group (L-CY). Treatment of loperamide reduced the wet weight and water content of fecal pellets, but increased the number of fecal pellets in the distal colon. Meanwhile, the fecal weight of the L-BEY group showed an increase of 43% and 23% versus the LOP and L-CY group, respectively. Also, the fecal water content in the L-BEY group was 14.5% and 6.8% higher than that in the LOP and L-CY group, respectively. In addition, the L-BEY group had the fewest fecal pellets in the distal colon. In the serum lipid parameters, the LOP group had a HDL/total cholesterol ratio that was 43% lower than the NOR group, but the L-BEY group had 27% lower than NOR group. These results suggest that bifidus enhancer yogurt has superior effects when it comes to relieving loperamide-induced constipation in rats.

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References

  1. Azuma, N., Yamauchi, K., and Mitsuoka, T. (1984) Bifidus growth-promoting activity of a glycomacropeptide derived from human k-casein. Agric. Biol. Chem. 48, 2159-2162. https://doi.org/10.1271/bbb1961.48.2159
  2. Chen, H. L., Cheng, H. C., Liu, Y. J., Liu, S. Y., and Wu, W. T. (2006) Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults. Nutr. 22, 1112-1119. https://doi.org/10.1016/j.nut.2006.08.009
  3. Cho, Y. S., Kim, S. I., and Han, Y. S (2008) The quality characteristics of slander glasswort yogurt and its effect on the relief from constipation. Korean J. Food Cookery Sci. 24, 212-221.
  4. Conrazziari, E. (1999) Need of the drug for the treatment of chronic constipation. Ital. J. Gastroenterol. Hapatol. 31, 232-233.
  5. Dimsdale, J. E. and Herd, J. A (1982) Variability of plasma lipids in response to emotional arousal. Psychosomatic Med. 44, 413-430. https://doi.org/10.1097/00006842-198211000-00004
  6. Dimsdale, J. E., Herd, J. A., and Hartley, L. H. (1983) Epinephrine mediated increases in plasma cholesterol. Psychosomatic Med. 45, 227-231. https://doi.org/10.1097/00006842-198306000-00005
  7. Farombi, E. O., Nwankow, J. O., and Emerole, G. O. (1997) Possible modulatory effect of browned yam flour diet on chemically-induced toxicity in the rat. Food Chem. Toxicol. 35, 975-979. https://doi.org/10.1016/S0278-6915(97)87266-3
  8. Fontaine, J, U., Moughan, P, J., and Rutherfurd, S. M. (2007) Effect of heat damage in an autoclave on the reactive lysine contents of soy products and corn distillers dried grains with solubles. Use of the results to check on lysine damage in common qualities of these ingredients. J. Agr. Food Chem. 55, 10737-10734. https://doi.org/10.1021/jf071747c
  9. Frankenhaeuser, M. (1971) Behavior and circulating catecholamines. Brain Res. 31, 241-262. https://doi.org/10.1016/0006-8993(71)90180-6
  10. Freyschuss, U., Hjemdahl, P., Juhlin-Dannfelt. A., and Linde, B. (1986) Cardiovascular and metabolic responses to low dose epinephrine infusion: an invasive study in humans. Clin. Sci. 70, 199-206.
  11. Ganesan, V., Rosentrater, K. A., and Muthukumarappan, K. (2007) Modeling the flow properties of DDGS. Cereal Chem. 84, 556-562. https://doi.org/10.1094/CCHEM-84-6-0556
  12. Hjemdahl, P. and Linde, B. (1983) Influence of circulating NE and Epi on adipose tissue, vascular resistance and lipolysis in humans. Am. J. Physiol. 245, H447-H452.
  13. Hughes, D. B. and Hoover, D. (1991) Bifidobacteria; their potential for use in American dairy products. Food Technol. 54, 74-83.
  14. Janer, C., Pelaez, C., and Requena, T. (2004) Caseinomacropeptide and whey protein concentrate enhance Bifidobacterium lactis growth in milk. Food Chem. 86, 263-267. https://doi.org/10.1016/j.foodchem.2003.09.034
  15. Jeon, J. R., Kim. J. Y., and Choi, J. H. (2007) Effect of yam yogurt on colon mucosal tissue of rats with loperamideinduced constipation. Food Sci. Biotechnol. 16, 605-609.
  16. Kim, D. G., Jin, Y. G., Jin, J. Y., Kim, S. C., Kim, S. C., Han, C. H., and Lee, Y. J. (2011) Effects of the Actindia chinensis on loperamide-induced constipation in rat. Korean J. Plant Res. 24, 61-68. https://doi.org/10.7732/kjpr.2011.24.1.061
  17. Kim, D. H., Kim, J. H., Kim, C. H., You, J. H., Hwang, B., Lee, H. J., Kim, J. D., and Lee, H. Y. (2005) Screening of antistress activities in extracts from Korean medicinal herbs. Korean J. Med. Crop. Sci. 13, 103-109.
  18. Kim, H. J., Kim. S. I., and Han, Y. S. (2008) Effects of sea tangle extract and sea tangle yogurt on constipation relief. Korean J. Food Cookery Sci. 24, 59-67.
  19. Kim, H. K. (2000) Studies on the fermentation properties of yoghurt added with mulberry. MS thesis, Chungnam Nat. Univ., Daejeon, Korea.
  20. Kim, I. S., Joo, E. J., Lee, K. J., and Park, E. S. (2003) Clinical nutrition and dietetic therapy. Hyoil Cultural Company, Seoul, Korea, pp. 94-107 (in Koean)
  21. Kim, J. H. (2010) Immune and anti-stress activities of pine needle and the quality characteristics of pine needle yogurt. MS thesis, Sookmyung Women's Univ., Seoul, Korea.
  22. Lee, J. J., Lee, Y. M., Jung, S. K., Kim, K. Y., and Lee, M. Y. (2008) Effects of dietary mulberry leaf on loperamideinduced constipation in rats. Korean J. Food Preserv. 15, 280-287.
  23. Nakamum, I., Agata, G., Mizutani, M., and Lino, H. (2001) Effects of brewer's yeast cell wall on constipation and defecation in experimentally constipated rats. Biosci. Biotech. 65, 774-780 https://doi.org/10.1271/bbb.65.774
  24. Park, M. K., Jin, Y. G., Kim, D. G., Jin, J. Y., and Lee, Y. J. (2007) Effects of lenitinus edodes extract on the loperamideinduced constipation in rats. Korean J. Food Sci. Technol. 39, 88-93.
  25. Poch, M. and Bezkorovainy, A. (1988) Growth-enhancing supplements for various species of the genus Bifidobacterium. J. Dairy Sci. 71, 3214-3221. https://doi.org/10.3168/jds.S0022-0302(88)79926-9
  26. SAS (2008) SAS/STAT Software for PC. Release 9.2, SAS Institute Inc., Cary, NC, USA.
  27. Schiller, L. R., Santa Anan, C. A., Moravski, S. C., and Fordtran, J. S. (1984) Mechanism of the antidiarrheal effect of loperamide. Gastroenterol. 86, 1475-1480.
  28. Shimotoyodome, A., Meguro, S., Hase, T., Tokimitsu, I. and Sakata, T. (2000) Decreased colonic mucus in rats with loperamide- induced constipation. Comp. Biochem. Physiol. 126, 203-211. https://doi.org/10.1016/S1095-6433(00)00194-X
  29. Shimotoyodome, A., Meguro, S., Hase, T., Tokimitsu, I., and Sakata, T. (2001) Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation. Digest. Dis. Sci. 46, 1482-1489. https://doi.org/10.1023/A:1010644021888
  30. Shin, K. O., Jeon, J. R., Lee, J. S., Kim, J. Y., Lee, C. H., Kim, S. D., Yu, Y. S., and Nam, D. H. (2006) Lactic acid fermentation of Chinese yam (dioscorea batatasdecne) flour and its pharmacological effect on gastrointestinal function in rat model. Biotechnol. Bioproc. E. 11, 240-244. https://doi.org/10.1007/BF02932037
  31. Sinn, D. H., Song, J. H., Kim, H. J., Lee, J. H., Son, H. J., Chang, D. K., Kim, Y. H., Kim, J., J., Rhee, J. C., and Rhee, P. L. (2008) Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome. Digest. Dis. Sci. 53, 2714-2718. https://doi.org/10.1007/s10620-007-0196-4
  32. Song, M. H. (2005) Nutritional components and nutritive value of corn-DDGS about milk cow, beef cattle, pig, and fowl. Kofeed 15, 44-51.
  33. Wald, A. (2007) Appropriate use of laxatives in the management of constipation. Curr. Gastroenterol. Rep. 9, 410-414. https://doi.org/10.1007/s11894-007-0051-y
  34. Woo, S. J. and Mang, Y. S. (1998) Milk and dairy products in human nutrition. Hyoil Cultural Company, Seoul, Korea. pp. 53-65 (in Korean).

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