The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Mountain cultivated ginseng water boiled extract decreases blood glucose level and improves lipid metabolism in male db/db mice

산양산삼(山養山蔘) 열수추출물이 db/db 마우스 당뇨모델에서 혈중 지질대사와 혈당에 미치는 영향

  • Kim, Eung-Lae (Woori Institute of Mountain Cultivated Ginseng) ;
  • Kim, Chang-Sik (Woori Institute of Mountain Cultivated Ginseng) ;
  • Lee, Hee-Young (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University) ;
  • Lee, Hye-Rim (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University) ;
  • Kim, Eung-Yeol (Kongju Communication Arts University) ;
  • Yoon, Mi-Chung (Dept. of Life Sciences, Mok-Won University) ;
  • Shin, Soon-Shik (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University)
  • 김응래 (우리산삼효능연구소) ;
  • 김창식 (우리산삼효능연구소) ;
  • 이희영 (동의대학교 한의과대학 방제학교실 및 한의학연구소) ;
  • 이혜림 (동의대학교 한의과대학 방제학교실 및 한의학연구소) ;
  • 김응렬 (공주영상대학교) ;
  • 윤미정 (목원대학교 바이오건강학부) ;
  • 신순식 (동의대학교 한의과대학 방제학교실 및 한의학연구소)
  • Received : 2012.02.13
  • Accepted : 2012.03.16
  • Published : 2012.03.30
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Abstract

Objectives : We investigated the effects of mountain cultivated ginseng water boiled extract(MCG) on blood glucose and insulin levels, and examined whether lipid metabolism are improved by it in male db/db mice(a murine model of type 2 diabetes mellitus). Methods : 9 weeks old, male db/db mice were divided into 5 groups : C57BL/6J normal, control, MCG-250mg/kg (MCG-1), MCG-500mg/kg(MCG-2) and MCG-1000mg/kg(MCG-3). After mice were treated with MCG for 8 weeks, we measured body weight, food intake, fat weight, visceral organ weight and blood glucose, insulin and lipid levels. Results : 1. We found no difference in body weight, food intake, fat weight and visceral organ weight among the animal groups. 2. Compared with controls, MCG-treated mice had lower blood glucose level and higher blood insulin levels, the magnitude of which was prominent in MCG-2. 3. Compared with controls, MCG-treated mice had lower LDL-cholesterol and higher HDL-cholesterol levels. 4. Compared with controls, MCG-treated mice had blood triglyceride and free fatty acid levels, the magnitude of which was prominent in MCG-2. 5. Blood AST and ALT concentrations were not changed by MCG, indicating MCG do not show any toxic effects. Conclusions : These results demonstrate that MCG effectively increases blood insulin level and decreases blood glucose level, blood lipid levels, and prevents and improves diabetic dyslipidemia and cardiovascular disease.

Keywords

References

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