Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

ABO and Rh Blood Groups and Risk of Colorectal Adenocarcinoma

  • Urun, Yuksel (Department of Medical Oncology, Ankara University Faculty of Medicine) ;
  • Ozdemir, Nuriye Yildirim (Department of Medical Oncology, Ankara Numune Research and Educational Hospital) ;
  • Utkan, Gungor (Department of Medical Oncology, Ankara University Faculty of Medicine) ;
  • Akbulut, Hakan (Department of Medical Oncology, Ankara University Faculty of Medicine) ;
  • Savas, Berna (Department of Pathology, Ankara University Faculty of Medicine) ;
  • Oksuzoglu, Berna (Department of Medical Oncology, Dr. Abdurrahman Yurtaslan Research and Education Hospital) ;
  • Oztuna, Derya Gokmen (Department of Biostatistics, Ankara University Faculty of Medicine) ;
  • Dogan, Izzet (Department of Internal Medicine, Ankara University Faculty of Medicine) ;
  • Yalcin, Bulent (Faculty of Medicine, Department of Medical Oncology, Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital) ;
  • Senler, Filiz Cay (Department of Medical Oncology, Ankara University Faculty of Medicine) ;
  • Onur, Handan (Department of Medical Oncology, Ankara University Faculty of Medicine) ;
  • Demirkazik, Ahmet (Department of Medical Oncology, Ankara University Faculty of Medicine) ;
  • Zengin, Nurullah (Department of Medical Oncology, Ankara Numune Research and Educational Hospital) ;
  • Icli, Fikri (Department of Medical Oncology, Ankara University Faculty of Medicine)
  • Published : 2012.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic and gastric cancer. However, it is unclear whether there is such an association with colorectal cancer (CRC). In this study, possible relationships between ABO blood groups and Rh factor and KRAS status in patients with CRC were investigated. Materials and Methods: In 1,620 patients with CRC, blood group and Rh factor were examined and compared with the control group of 3,022,883 healthy volunteer blood donors of the Turkish Red Crescent between 2004 and 2011. The relationship of blood groups with wild type K-ras status was also evaluated. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (45% A, 7.2% AB, 16.4% B, 31.4% O, and 87.2% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0.099). However, there were statistically significant difference between patients and controls with respect to O vs. non O blood group (p=0.033) and marginally significant difference for A vs. non-A blood group (p=0.052). Among patients, the median age was 62 (range 17-97), 58.1% were male. There were no statistically significant differences respect to sex and K-ras status. Conclusion: In present study, the ABO/Rh blood groups were statistically significantly associated with the risk of CRC. There were no relationship between K-ras status and ABO blood group and Rh factor. However further studies with larger numbers of patients are needed to establish the role of blood groups and to define t he mechanisms by which ABO blood type affect CRC.

Keywords

References

  1. Aird I, HH Bentall, JA Mehigan, JA Roberts (1954). The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration. Br Med J, 2, 315-21. https://doi.org/10.1136/bmj.2.4883.315
  2. Aird I, HH Bentall, J Roberts (1953). Relationship between cancer of stomach and the ABO blood groups. Bri Med J, 1, 799. https://doi.org/10.1136/bmj.1.4814.799
  3. Amundadottir L, P Kraft, RZ Stolzenberg-Solomon, et al (2009). Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet, 41, 986-90. https://doi.org/10.1038/ng.429
  4. Dabelsteen E, N Graem, H Clausen, S Hakomori (1988). Structural variations of blood group A antigens in human normal colon and carcinomas. Cancer Res, 48, 181-7.
  5. Dahiya R, SH Itzkowitz, JC Byrd, YS Kim (1989). ABH blood group antigen expression, synthesis, and degradation in human colonic adenocarcinoma cell lines. Cancer Res, 49, 4550-6.
  6. Dall'olio F (1996). Protein glycosylation in cancer biology: an overview. Clin Mol Pathol, 49, 126-35. https://doi.org/10.1136/mp.49.3.M126
  7. Edgren G, H Hjalgrim, K Rostgaard, et al (2010). Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol, 172, 1280-5. https://doi.org/10.1093/aje/kwq299
  8. Greer JB, MH Yazer, JS Raval, et al (2010). Significant association between ABO blood group and pancreatic cancer. World J Gastroenterol, 16, 5588-91. https://doi.org/10.3748/wjg.v16.i44.5588
  9. Hosoi E (2008). Biological and clinical aspects of ABO blood group system. J Med Invest, 55, 174-82. https://doi.org/10.2152/jmi.55.174
  10. Iodice S, P Maisonneuve, E Botteri, MT Sandri, AB Lowenfels (2010). ABO blood group and cancer. Eur J Cancer, 46, 3345-50. https://doi.org/10.1016/j.ejca.2010.08.009
  11. Jemal A, F Bray, MM Center, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  12. Khalili H, BM Wolpin, ES Huang, et al (2011). ABO blood group and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev, 20, 1017-20. https://doi.org/10.1158/1055-9965.EPI-10-1250
  13. Nakagoe T, K Fukushima, A Nanashima, et al (2001). Comparison of the expression of ABH/Lewis-related antigens in polypoid and non-polypoid growth types of colorectal carcinoma. J Gastroenterol Hepatol, 16, 176-83. https://doi.org/10.1046/j.1440-1746.2001.02425.x
  14. Schoentag R, FJ Primus, W Kuhns (1987). ABH and Lewis blood group expression in colorectal carcinoma. Cancer Res, 47, 1695-700.
  15. Wolpin BM, AT Chan, P Hartge, et al (2009). ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst, 101, 424-31. https://doi.org/10.1093/jnci/djp020

Cited by

  1. Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey vol.14, pp.5, 2013, https://doi.org/10.7314/APJCP.2013.14.5.2801
  2. ABO Blood Groups are Not Associated with Treatment Response and Prognosis in Patients with Local Advanced Non-Small Cell Lung Cancer vol.14, pp.6, 2013, https://doi.org/10.7314/APJCP.2013.14.6.3945
  3. Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for Lynch Syndrome vol.10, pp.6, 2015, https://doi.org/10.1371/journal.pone.0130018
  4. Association between ABO Genotype and Risk of Hepatocellular Carcinoma in Koreans vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.2771
  5. Epidemiologic characteristics of oral cancer: single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center vol.35, pp.1, 2016, https://doi.org/10.1186/s40880-016-0078-2