The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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A Study on Heart Rate Variability(HRV) of Women with Fibroadenoma

유방 섬유선종이 있는 2, 30대 여성의 HRV 특성 연구

  • 안지윤 (강남경희한방병원) ;
  • 최석영 (강남경희한방병원) ;
  • 이미주 (강남경희한방병원) ;
  • 이진무 (경희대학교 한의과대학 한방부인과학교실) ;
  • 장준복 (경희대학교 한의과대학 한방부인과학교실) ;
  • 이경섭 (강남경희한방병원) ;
  • 이창훈 (강남경희한방병원)
  • Received : 2012.10.26
  • Accepted : 2012.11.10
  • Published : 2012.11.30
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Abstract

Purpose: This study aims to analyze Heart Rate Variability(HRV) in women with fibroadenoma compared with non-fibroadenoma women. Methods: We studied 82 patients visiting Kang-Nam Kyung-Hee Korean Hospital Medical Examination Center from January, 2010 to November, 2011. The subjects were categorized in two groups, fibroadenoma group(n=16) and non-fibroadenoma group (n=66). We investigated the difference of HRV between two groups. Results: The square root of the mean squared difference of successive NNs (RMSSD) in fibroadenoma group is significantly lower than non-fibroadenoma group. LF/HF ratio in fibroadenoma group is significantly higher than non-fibroadenoma group. There was no significant difference in low frequency(LF) and high frequency (HF). However, normalized LF in fibroadenoma group is significantly higher than non-fibroadenoma group. In addition, normalized HF in fibroadenoma group is significantly lower than non-fibroadenoma group. Conclusions: Fibroadenoma group is related to autonomic nerve imbalances that is assumed by psychological problems.

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References

  1. Alle KM, et al. Conservative management of fibroadenoma of the breast. Br. J. Surg. 1997;83:992-3.
  2. Greenberg R, Skornick Y, Kaplan O. Management of breast fibroadenomas. J. Gen. Intern. Med. 1998;13:640-5. https://doi.org/10.1046/j.1525-1497.1998.cr188.x
  3. 대한산부인과학회. 부인과학. 서울:도서출판 고려의학. 2008:921-31.
  4. McKenna MC, et al. Psychosocial factors and the development of breast cancer: a meta-analysis. Health Psychol. 1999;18(5):520-31. https://doi.org/10.1037/0278-6133.18.5.520
  5. 대한한방부인과학회. 한방여성의학(상). 서울:도서출판 정담. 2007:432-5.
  6. 허준. 동의보감. 경남:동의보감 출판사. 2006:77, 679-89.
  7. 우종민. 심박동수 변이(Heart Rate Variability) 측정법의 개념과 임상적 활용. 정신신체의학. 2004;12(1):3-14.
  8. 김민정. 유방질환 관리 지침. 제 97차 대한산부인과학회 학술대회 교육강연. 2011:81-4.
  9. Venta LA, Dudiak CM, Solomon CC. Sonographic evaluation of the breast. Radiographics. 1994;14(1):29-50. https://doi.org/10.1148/radiographics.14.1.8128064
  10. 이진표, 김유사. 한국인의 유방 섬유선종. 대한외과학회지. 1993;44(3):374-81.
  11. Dent DM, Cant PJ. Fibroadenoma. World J Surg. 1989;13:706-10. https://doi.org/10.1007/BF01658418
  12. 노동영 외. 양성 유방 질환의 임상적 역학적 연구. 대한외과학회지. 1993; 44(6):797-808.
  13. 노만수, 이홍주, 양정현. 유방의 섬유선종에서 발생한 침윤성 유방암. 대한외과학회지. 1994;47(6):881.
  14. 이상달 외. 유방의 섬유선종에서 발견된 관상피내암. 대한외과학회지. 2000; 58(1):44-9.
  15. 박해린 외. 맘모톰을 이용한 치료적 목적의 유방 양성 병변 절제술 1003례 보고. 대한외과학회지. 2005;68(2):96-101.
  16. Ignotz RA, Massague J. Transforming growth factor-2 stimulates the expression of fibronectin and collagen and their incorporation to the extracellular matrix. J. Biol. Chem. 1986;261:4337-45.
  17. Berthois Y, Dong XF, Martin PM. Regulation of epidermal growth factor receptor by estrogen and anti-estrogen in the human breast cancer cell line MCF-7. Biochem. Biophys. Res. Commun. 1989;159:126-31. https://doi.org/10.1016/0006-291X(89)92413-3
  18. Chrysogelos SA, et al. Mechanisms of EGF receptor regulation in breast cancer cells. Breast Cancer Res. Treat. 1994;31:227-36. https://doi.org/10.1007/BF00666156
  19. Ory H, et al. Oral contraceptives and reduced risk of benign breast diseases. N Engl J Med. 1976;294:419-22. https://doi.org/10.1056/NEJM197602192940804
  20. Trapido EJ, et al. Estrogen replacement therapy and benign breast disease. J Natl Cancer Inst. 1984;73:1101-5.
  21. Brinton LA, et al. Risk factors for benign breast disease. Am J Epidemiol 1981;113:203-14. https://doi.org/10.1093/oxfordjournals.aje.a113089
  22. Nelson ZC, et al. Risk Factors for Fibroadenoma in a Cohort of Female Textile Workers in Shanghai, China. Am J Epidemiol. 2002;156:599-605. https://doi.org/10.1093/aje/kwf094
  23. Wright RJ. Stress-Related Programming of Autonomic Imbalance: Role in Allergy and Asthma. Chemical Immunol Allergy. 2012;98:32-47.
  24. 羅元愷 主編. 中醫婦科學. 北京:人民出版社. 1998:313-41.
  25. 김정진, 이경섭, 송병기. 유방종괴에 관한 문헌적 고찰 - 유방과 혈의 관계를 중심으로 -. 대한한방부인과학회지. 1998; 11(2):29-43.
  26. 김윤상, 임은미. 유방질환에 관한 한방부인과적 연구. 대한한방부인과학회지. 2012;25(3):103-16.
  27. Malik M. Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. Circulation. 1996;93:1043-65.
  28. 장세진 외. 직무스트레스, 심박동수 변이 및 대사증후군. 대한산업의학회지. 2004;16(1):70-80
  29. 이지인 외. 기울증으로 진단된 2-30대 환자의 심박변동 분석. 동의신경정신과학회지. 2003;14(2):135-43.
  30. Yu JH, Hwang IT. The Proper Approaches For Breast Disease. Korean J Obstet Gynecol. 2011;54(2):67-78. https://doi.org/10.5468/KJOG.2011.54.2.67