Acknowledgement
Supported by : National Research Foundation of Korea (NRF)
References
- Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, Kalachikov S, Gilliam TC, Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999;59:59-65 https://doi.org/10.1006/geno.1999.5851
- Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, Thomas-Tikhonenko A, Thompson CB. Autophagy inhibition enhances therapy-induced apoptosis in a Mycinduced model of lymphoma. J Clin Invest 2007;117:326-36 https://doi.org/10.1172/JCI28833
- Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 2011;17:654-66 https://doi.org/10.1158/1078-0432.CCR-10-2634
- Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008;68:1485-94 https://doi.org/10.1158/0008-5472.CAN-07-0562
- Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001;276:35243-6 https://doi.org/10.1074/jbc.C100319200
- Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, Van Etten RA, Donato N, Hunter A, Dinsdale D, Tirro E, Vigneri P, Nicotera P, Dyer MJ, Holyoake T, Salomoni P, Calabretta B. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009;119:1109-23 https://doi.org/10.1172/JCI35660
- Berry DL, Baehrecke EH. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 2007;131:1137-48 https://doi.org/10.1016/j.cell.2007.10.048
- Bialik S, Kimchi A. Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy. Curr Opin Cell Biol 2010;22:199-205 https://doi.org/10.1016/j.ceb.2009.11.004
- Bommareddy A, Hahm ER, Xiao D, Powolny AA, Fisher AL, Jiang Y, Singh SV. Atg5 regulates phenethyl isothiocyanateinduced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res 2009;69:3704-12 https://doi.org/10.1158/0008-5472.CAN-08-4344
- Boya P, Gonzalez-Polo RA, Casares N, Perferrini JL, Dessed P, Larochette N, Metivier, D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005;25:1025-40 https://doi.org/10.1128/MCB.25.3.1025-1040.2005
- Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M, Walker R, Hermann RS. Active cell death induced by theanti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 1996;17:1595-607 https://doi.org/10.1093/carcin/17.8.1595
- Buytaert E, Callewaert G, Hendrickx N, Scorrano L, Hartmann D, Missiaen L, Vandenheede JR, Heirman I, Grooten J, Agostinis P. Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. FASEB J 2006;20:756-8 https://doi.org/10.1096/fj.05-4305fje
- Buzzai M, Jones RG, Amaravadi RK, Lum JJ, De Berardinis RJ, Zhao F, Viollet B, Thompson CB. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007;67:6745-52 https://doi.org/10.1158/0008-5472.CAN-06-4447
- Calabretta B, Salomoni P. Inhibition of autophagy: a new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors. Leuk Lymphoma 2011;52 (Suppl 1):S54-9 https://doi.org/10.3109/10428194.2010.546913
- Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L, Houghton JA, Huang P, Giles FJ, Cleveland JL. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 2007;110:313-22 https://doi.org/10.1182/blood-2006-10-050260
- Chen N, Karantza-Wadsworth V. Role and regulation of autophagy in cancer. Biochim Biophys Acta 2009;1793: 1516-23 https://doi.org/10.1016/j.bbamcr.2008.12.013
- Chen N, Karantza V. Autophagy as a therapeutic target in cancer. Cancer Biol Ther 2011;11:157-68 https://doi.org/10.4161/cbt.11.2.14622
- Chen S, Rehman SK, Zhang W, Wen A, Yao L, Zhang J. Autophagy is a therapeutic target in anticancer drug resistance. Biochim Biophys Acta 2010;1806:220-9
- Claerhout S, Verschooten L, Van Kelst S, De Vos R, Proby C, Agostinis P, Garmyn M. Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma. Int J Cancer 2010;127:2790-803 https://doi.org/10.1002/ijc.25300
- Crowley LC, Elzinga BM, O'Sullivan GC, McKenna SL. Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment. Am J Hematol 2011;86:38-47 https://doi.org/10.1002/ajh.21914
- Davis CD. Nutritional interactions: Credentialing of molecular targets for cancer prevention. Soc Exp Biol Med 2007;232: 176-83
- Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006;10:51-64 https://doi.org/10.1016/j.ccr.2006.06.001
- Denton D, Shravage B, Simin R, Mills K, Berry DL, Baehrecke EH, Kumars S. Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol 2009;19:1741-6 https://doi.org/10.1016/j.cub.2009.08.042
- Dikic I, Johansen T, Kirkin V. Selective autophagy incancer development and therapy. Cancer Res 2010;70:3431-4 https://doi.org/10.1158/0008-5472.CAN-09-4027
- DiPaola RS, Dvorzhinski D, Thalasila A, Garikapaty V, Doram D, May M, Bray K, Mathew R, Beaudoin B, Karp C, Stein M, Foran DJ, White E. Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate 2008;68:1743-52 https://doi.org/10.1002/pros.20837
- Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 2009;16:966-75 https://doi.org/10.1038/cdd.2009.33
- Ertmer A, Huber V, Gilch S, Yoshimori T, Erfle V, Durster J, Elsasser M Schatzl HM. The anticancer drug imatinib induces cellular autophagy. Leukemia 2007;21:936-42 https://doi.org/10.1038/sj.leu.2404606
- Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer indiabetic patients. BMJ 2005;330:1304-5 https://doi.org/10.1136/bmj.38415.708634.F7
- Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal 2010;3:ra81 https://doi.org/10.1126/scisignal.2001017
- Fazi B, Bursch W, Fimia GM, Nardacci R, Piacentini M, Di Sano F, Piredda L. Fenretinide induces autophagic cell death in caspase-defective breast cancer cells. Autophagy 2008;4:435-41 https://doi.org/10.4161/auto.5669
- Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res 2008;68:9323-30 https://doi.org/10.1158/0008-5472.CAN-08-2873
- Futreal PA, Soderkvist P, Marks JR, Iglehart JD, Cochran C, Barrett JC, Wiseman RW. Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res 1992;52:2624-7
- Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knigh RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nunez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012;19:107-20 https://doi.org/10.1038/cdd.2011.96
- Ganley IG, Wong PM, Gammoh N, Jiang X. Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell 2011;42:731-43 https://doi.org/10.1016/j.molcel.2011.04.024
- Gao X, Zacharek A, Salkowski A, Grignon DJ, Sakr W, Porter AT, Honn KV. Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer. Cancer Res 1995;55:1002-5
- Gozuacik D, Kimchi A. Autophagy and cell death. Curr Top Dev Biol 2007;78:217-45
- Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004;23:2891-906 https://doi.org/10.1038/sj.onc.1207521
- Grander D, Kharaziha P, Laane E, Pokrovskaja K, Panaretakis T. Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies. Autophagy 2009;5:1198-200 https://doi.org/10.4161/auto.5.8.10122
- Gunja N, Roberts D, McCoubrie D, Lamberth P, Jan A, Simes DC, Hackett P, Buckley NA. Survival after massive hydroxychloroquine overdose. Anaesth Intensive Care 2009;37:130-3
- Gupta A, Roy S, Lazar AJ, Wang WL, McAuliffe JC, Reynoso D, McMahon J, Taguchi T, Floris G, Debiec-Rychter M, Schoffski P, Trent JA, Debnath J, Rubin BP. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci USA 2010;107:14333-8 https://doi.org/10.1073/pnas.1000248107
- Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74 https://doi.org/10.1016/j.cell.2011.02.013
- Hannigan AM, Gorski SM. Macroautophagy: the key ingredient to a healthy diet? Autophagy 2009;5:140-51 https://doi.org/10.4161/auto.5.2.7529
- Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009;460:392-5 https://doi.org/10.1038/nature08221
- Hoare M, Young AR, Narita M. Autophagy in cancer: Having your cake and eating it. Semin Cancer Biol 2011;21:397-404
- Hosokawa N, Hara Y, Mizushima N. Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 2006;580:2623-9 https://doi.org/10.1016/j.febslet.2006.04.008
- Hoyer-Hansen M, Bastholm L, Mathiasen IS, Elling F,Jaattela M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 2005;12:1297-309 https://doi.org/10.1038/sj.cdd.4401651
-
Hoyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Bianchi K, Fehrenbacher N, Elling F, Rizzuto R, Mathiasen IS, Jaattela M. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-
${\beta}$ , and Bcl-2. Mol Cell 2007;25:193-205 https://doi.org/10.1016/j.molcel.2006.12.009 - Janku F, McConkey DJ, Hong DS, Kurzrock R. Autophagy as a target for anticancer therapy. Nat Rev ClinOncol 2011;8: 528-39
- Jones RG, Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 2009; 23:537-48 https://doi.org/10.1101/gad.1756509
- Juhasz G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol 2008;181:655-66 https://doi.org/10.1083/jcb.200712051
- Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Oshumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, Is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-8 https://doi.org/10.1093/emboj/19.21.5720
- Kanematsu S, Uehara N, Miki H, Yoshizawa K, Kawanaka A, Yuri T, Tsubura A. Autophagy inhibition enhances sulforaphane- induced apoptosis in human breast cancer cells. Anticancer Res 2010;30:3381-90
- Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003;63:2103-8
- Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y,Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 2004;11:448-57 https://doi.org/10.1038/sj.cdd.4401359
- Karanta-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007;21:1621-35 https://doi.org/10.1101/gad.1565707
- Kawaguchi T, Miyazawa K, Moriya S, Ohtomo T, Che XF, Naito M, Itoh M, Tomoda A. Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagylysosome and ER stress. Int J Oncol 2011;38:643-54
- Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 2007;67: 6314-24 https://doi.org/10.1158/0008-5472.CAN-06-4217
- Kim EH, Choi KS. A critical role of superoxide anion in selenite-induced mitophagic cell death. Autophagy 2008;4: 76-8 https://doi.org/10.4161/auto.5119
- Kim RH, Coates JM, Bowles TL, McNerney GP, Sutcliffe J, Jung JU, Gandour-Edwards R, Chuang FY, Bold RJ, Kung HJ. Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res 2009;69:700-8 https://doi.org/10.1158/0008-5472.CAN-08-3157
- Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007;3:452-60 https://doi.org/10.4161/auto.4451
- Kondo Y, Kondo S. Autophagy and cancer therapy: Autophagy 2006;2:85-90 https://doi.org/10.4161/auto.2.2.2463
- Kremer JM. Rational use of new and existing diseasemodifying agents in rheumatoid arthritis. Ann Intern Med 2001;134:695-706 https://doi.org/10.7326/0003-4819-134-8-200104170-00013
- Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008;9:1004-10 https://doi.org/10.1038/nrm2529
- Laane E, Tamm KP, Buentke E, Ito K, Kharaziha P, Oscarsson J, Corcoran M, Bjorklund A-C, Hultenby K, Lundin J, Heyman M, Soderhall S, Mazur J, Porwit A, Pandolfi PP, Zhivotovsky B, Panaretakis T, Grander D. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ 2009;16: 1018-29 https://doi.org/10.1038/cdd.2009.46
- Levine B, Klionsky DJ. Development of self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004;6:463-7 https://doi.org/10.1016/S1534-5807(04)00099-1
- Levine B, Kroemer G. Autophagy in the pathogenesisof disease. Cell 2008;132:27-42 https://doi.org/10.1016/j.cell.2007.12.018
- Levy JM, Thorburn A. Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther 2011;131:130-41 https://doi.org/10.1016/j.pharmthera.2011.03.009
- Li J, Hou N, Faried A, Tsutsumi S, Kuwano H. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer 2010;46:1900-9 https://doi.org/10.1016/j.ejca.2010.02.021
- Li M, Jiang X, Liu D, Na Y, Gao GF, Xi Z. Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy 2008;4:54-60 https://doi.org/10.4161/auto.5209
- Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006;8: 688-99 https://doi.org/10.1038/ncb1426
- Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27 (kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007;9:218-24 https://doi.org/10.1038/ncb1537
- Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999;402:672-6 https://doi.org/10.1038/45257
- Ligresti G, Militello L, Steelman LS, Cavallaro A, Basile F, Nicoletti F, Stivala F, McCubrey JA, Libra M. PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches. Cell Cycle 2009;8:1352-8 https://doi.org/10.4161/cc.8.9.8255
- Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM, Perez-Soler R. PM02734 (elisidepsin) induces caspaseindependent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. Clin Cancer Res 2011;17:5353-66 https://doi.org/10.1158/1078-0432.CCR-10-1948
- Liu D, Yang Y, Liu Q, Wang J. Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol 2011;28:105-11 https://doi.org/10.1007/s12032-009-9397-3
-
Lomonaco SL, Finniss S, Xiang C, Decarvalho A, Umansky F, Kalkanis SN, Mikkelsen T, Brodie C. The induction of autophagy by
${\gamma}$ -radiation contributes to the radioresistance of glioma stem cells. Int J Cancer 2009;125:717-22 https://doi.org/10.1002/ijc.24402 - LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 2008; 11:32-50 https://doi.org/10.1016/j.drup.2007.11.003
- Luo Z, Zang M, Guo W. AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol 2010;6:457-70 https://doi.org/10.2217/fon.09.174
- Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, Geneste O, Kroemer G. BH3-onlyproteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007;3:374-6 https://doi.org/10.4161/auto.4237
- Maiuri MC, Galluzzi L, Morselli E, Kepp O, Malik SA, Kroemer G. Autophagy regulation by p53. Curr Opin Cell Biol 2010; 22:181-5 https://doi.org/10.1016/j.ceb.2009.12.001
- Mann CD, Neal CP, Garcea G, Manson MM, Dennison AR, Berry DP. Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis. Eur J Cancer Prev 2009;18:13-25 https://doi.org/10.1097/CEJ.0b013e3282f0c090
- Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem 2007;282:18573-83 https://doi.org/10.1074/jbc.M701194200
- Martelli AM, Tazzari PL, Evangelisti C, Chiarini F, BlalockWL, BilliAM, ManzoliL, McCubreyJA, Cocco L. Targeting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Module for Acute Myelogenous Leukemia Therapy: From Bench to Bedside. Curr Med Chem 2007;14: 2009-23 https://doi.org/10.2174/092986707781368423
- Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007;21:1367-81 https://doi.org/10.1101/gad.1545107
- Milani M, Rzymski T, Mellor HR, Pike L, Bottini A, Generali D, Harris AL. The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res 2009;69:4415-23 https://doi.org/10.1158/0008-5472.CAN-08-2839
- Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007;3:542-5 https://doi.org/10.4161/auto.4600
- Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010;140:313-26 https://doi.org/10.1016/j.cell.2010.01.028
-
Moussay E, Kaoma T, Baginska J, Muller A, Van Moer K, Nicot N, Nazarov PV, Vallar L, Chouaib S, Berchem G, Janji B. The acquisition of resistance to
$TNF{\alpha}$ in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray. Autophagy 2011;7:760-70 https://doi.org/10.4161/auto.7.7.15454 - Nair S, Li W, Kong AN. Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells. Acta Pharmacol Sin 2007;28:459-72 https://doi.org/10.1111/j.1745-7254.2007.00549.x
- Ni Cheallaigh C, Keane J, Lavelle EC, Hope JC, Harris J. Autophagy in the immune response to tuberculosis: clinical perspectives. Clin Exp Immunol 2011;164:291-300 https://doi.org/10.1111/j.1365-2249.2011.04381.x
- Nishikawa T, Tsuno NH, Okaji Y, Shuno Y, Sasaki K, Hongo K, Sunami E, Kitayama J, Takahashi K, Nagawa H. Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells. Ann Surg Oncol 2010;17:592-602 https://doi.org/10.1245/s10434-009-0696-x
- O'Neill PM, Bray PG, Hawley SR, Ward SA, Park BK. 4-Aminoquinolines-past, present, and future: a chemical perspective. Pharmacol Ther 1998;77:29-58 https://doi.org/10.1016/S0163-7258(97)00084-3
- Onodera J, Ohsumi Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem 2005;280:31582-6 https://doi.org/10.1074/jbc.M506736200
- Paglin S, Hollister T, Delohery T, Kackett N, McMahill M, Sphicas E, Domingo D, Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001;61:439-44
- Pan MH, Ho CT. Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev 2008;37:2558-74 https://doi.org/10.1039/b801558a
-
Park EJ, Choi KS, Kwon TK.
${\beta}$ -Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells. Chem Biol Interact 2011;189: 37-44 https://doi.org/10.1016/j.cbi.2010.10.013 - Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, Auberger P. Resveratrol promotes autophagic cell death in chronic myeogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res 2010;70:1042-52 https://doi.org/10.1158/0008-5472.CAN-09-3537
- Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005;280:20722-9 https://doi.org/10.1074/jbc.M413934200
- Qadir MA, Kwok B, Dragowska WH, To KH, Le D, Bally MB, Gorski SM. Macroautophagy inhibition sensitizes tamoxifenresistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Res Treat 2008;112:389-403 https://doi.org/10.1007/s10549-007-9873-4
- Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rose J, Eskelinen EL, Mizushima N, Oshumi Y, Cattoretti G, Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003;112:1809-20 https://doi.org/10.1172/JCI20039
- Rabinowitz JD, White E. Autophagy and metabolism. Science 2010;330:1344-8 https://doi.org/10.1126/science.1193497
- Ramakrishnan S, Nguyen TM, Subramanian IV, Kelekar A. Autophagy and angiogenesis inhibition. Autophagy 2007;3: 512-5
- Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia- Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010;90:1383-435 https://doi.org/10.1152/physrev.00030.2009
- Romanelli F, Smith KM. Hoven AD. Chloroquine and hydroxychloroquine as inhibitors of human immunodeficiency virus (HIV-1) activity. Curr Pharm Des 2004;10:2643-8 https://doi.org/10.2174/1381612043383791
- Rosenfeldt MT, Ryan KM. The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med 2009; 11:e36 https://doi.org/10.1017/S1462399409001306
- Rouschop KM, Wouters BG. Regulation of autophagy through multiple independent hypoxic signaling pathways. CurrMol Med 2009;9:417-24 https://doi.org/10.2174/156652409788167131
- Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, Egia A, Vazquez P, Blazquez C, Torres S, Garcia S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, Gonzalez-Feria L, Iovanna JL, Guzman M, Boya P, Velasco G. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 2009;119:1359-72 https://doi.org/10.1172/JCI37948
- Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler K, Vogelstein B, Velculescu VE. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004;304:554 https://doi.org/10.1126/science.1096502
- Schleicher SM, Moretti L, Varki V, Lu B. Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: implications for future therapeutic approaches. Drug Resist Updat 2010;13:79-86 https://doi.org/10.1016/j.drup.2010.04.002
-
Schoenlein PV, Periyasamy-Thandavan S, Samaddar JS, Jackson WH, Barrett JT. Autophagy facilitates the progression of
$ER{\alpha}$ -positive breast cancer cells to antiestrogen resistance. Autophagy 2009;5:400-3 https://doi.org/10.4161/auto.5.3.7784 - Schweichel JU, Merker HJ.The morphology of various types of cell death in prenatal tissues. Teratology 1973;7:253-66 https://doi.org/10.1002/tera.1420070306
- Shen HM, Codogno P. Autophagic cell death:Loch Ness monster or endangered species? Autophagy 2011;7:457-65 https://doi.org/10.4161/auto.7.5.14226
- Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa- Kobayashi S, Thompson CB, Tsujimoto Y. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004;6:1221-8 https://doi.org/10.1038/ncb1192
- Shingu T, Fujiwara K, Bogler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S. Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int J Cancer 2009;124:1060-71 https://doi.org/10.1002/ijc.24030
- Singletary K, Milner J. Diet, autophagy, and cancer: a review. Cancer Epidemiol Biomarkers Prev 2008;17:1596-610 https://doi.org/10.1158/1055-9965.EPI-07-2917
- Smith DM, Patel S, Raffoul F, Haller E, Mills GB, Nanjundan M. Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ 2010;17:1867-81 https://doi.org/10.1038/cdd.2010.53
- Suh Y, Afaq F, Khan N, Johnson JJ, Khusro FH, Mukhtar H. Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis 2010;31:1424-33 https://doi.org/10.1093/carcin/bgq115
- Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mule JJ, Pledger WJ, Wang HG. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 2007;9:1142-51 https://doi.org/10.1038/ncb1634
- Tan AC, Konczak I, Sze DM, Ramzan I. Molecular pathways for cancer chemoprevention by dietary phytochemicals. Nutr Cancer 2011;63:495-505 https://doi.org/10.1080/01635581.2011.538953
- Tiwari M, Bajpai VK, Sahasrabuddhe AA, Kumar A, Sinha RA, Behari S, Godbole MM. Inhibition of N-(4-hydroxyphenyl) retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis 2008;29: 600-9
- Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 2009;4:e6251 https://doi.org/10.1371/journal.pone.0006251
-
Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, Huang C, Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTORand hypoxia-induced factor
$1{\alpha}$ -mediated signaling. Autophagy 2011;7:966-78 https://doi.org/10.4161/auto.7.9.15863 - White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer.Clin Cancer Res 2009;15:5308-16 https://doi.org/10.1158/1078-0432.CCR-07-5023
- Wu Z, Chang PC, Yang JC, Chu CY, Wang LY, Chen NT, Ma AH, Desai SJ, Lo SH, Evans CP, Lam KS, Kung HJ. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes Cancer 2010; 1:40-9 https://doi.org/10.1177/1947601909358324
- Yang ZJ, Chee CE, Huang S, Sinicrope FA. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 2011;10:1533-41 https://doi.org/10.1158/1535-7163.MCT-11-0047
- Yao KC, Komata T, Kondo Y, Kanazawa T, Kondo S, Germano IM. Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 2003;98:378-84 https://doi.org/10.3171/jns.2003.98.2.0378
- Yogalingam G, Pendergast AM. Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components. J Biol Chem 2008;283:35941-53 https://doi.org/10.1074/jbc.M804543200
- Yu SW, Baek SH, Brennan RT, Bradley CJ, Park SK, Lee YS, Jun EJ, Lookingland KJ, Kim EK, Lee H, Goudreau JL, Kim SW. Autophagic death of adult hippocampal neural stem cells following insulin withdrawal. Stem Cells 2008;26: 2602-10 https://doi.org/10.1634/stemcells.2008-0153
- Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003;100:15077-82 https://doi.org/10.1073/pnas.2436255100
- Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci USA 2009;106:8923-8 https://doi.org/10.1073/pnas.0903621106
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- Treatment of Hominis placenta pharmacopuncture for a patient with mild neurocognitive disorder: Case report vol.22, pp.4, 2012, https://doi.org/10.3831/kpi.2019.22.037
- Autophagy activation is required for homocysteine-induced apoptosis in bovine aorta endothelial cells vol.6, pp.1, 2012, https://doi.org/10.1016/j.heliyon.2020.e03315
- The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target vol.27, pp.1, 2012, https://doi.org/10.1177/1073274820976664
- Knockdown of YAP/TAZ Inhibits the Migration and Invasion of Fibroblast Synovial Cells in Rheumatoid Arthritis by Regulating Autophagy vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/9510594
- Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti‐Austerity Activity against Human PANC‐1 Pancreatic Cancer Cells vol.15, pp.1, 2020, https://doi.org/10.1002/cmdc.201900549
- Recent Advances in Characterizing Natural Products that Regulate Autophagy vol.19, pp.18, 2012, https://doi.org/10.2174/1871520619666191015104458
- Curative effect of xanthohumol supplementation during liver fluke-associated cholangiocarcinogenesis: Potential involvement of autophagy vol.10, pp.3, 2020, https://doi.org/10.1016/j.jtcme.2019.02.001
- The Controversial Role of Autophagy in Tumor Development: A Systematic Review vol.49, pp.4, 2012, https://doi.org/10.1080/08820139.2019.1682600
- Periostin regulates autophagy through integrin α5β1 or α6β4 and an AKT‐dependent pathway in colorectal cancer cell migration vol.24, pp.21, 2012, https://doi.org/10.1111/jcmm.15756
- The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-mTORC1 axis vol.1866, pp.12, 2012, https://doi.org/10.1016/j.bbadis.2020.165970
- Autophagy and salivary gland cancer: A putative target for salivary gland tumors vol.42, pp.12, 2012, https://doi.org/10.1177/1010428320980568
- Carthami flos induces apoptosis by activating caspases and regulating mitogen-activated protein kinase and reactive oxygen species signaling pathways in AGS human gastric cancer cells vol.17, pp.74, 2012, https://doi.org/10.4103/pm.pm_127_20
- Autophagy in Viral Development and Progression of Cancer vol.11, pp.None, 2021, https://doi.org/10.3389/fonc.2021.603224
- Two Faces of Autophagy in the Struggle against Cancer vol.22, pp.6, 2012, https://doi.org/10.3390/ijms22062981
- Suppression of lysosomal acid alpha‐glucosidase impacts the modulation of transcription factor EB translocation in pancreatic cancer vol.112, pp.6, 2012, https://doi.org/10.1111/cas.14921
- Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer vol.22, pp.12, 2021, https://doi.org/10.3390/ijms22126599
- Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance vol.13, pp.13, 2012, https://doi.org/10.3390/cancers13133195
- The role of autophagy in controlling SARS‐CoV‐2 infection: An overview on virophagy‐mediated molecular drug targets vol.45, pp.8, 2012, https://doi.org/10.1002/cbin.11609
- Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives vol.35, pp.8, 2012, https://doi.org/10.1002/ptr.7082
- Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics vol.73, pp.None, 2012, https://doi.org/10.1016/j.semcancer.2020.10.010
- An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy vol.100, pp.2, 2012, https://doi.org/10.1124/molpharm.121.000234
- Serum DJ-1 Is a Biomarker of Colorectal Cancer and DJ-1 Activates Mitophagy to Promote Colorectal Cancer Progression vol.13, pp.16, 2012, https://doi.org/10.3390/cancers13164151
- Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action vol.90, pp.None, 2012, https://doi.org/10.1016/j.phymed.2021.153554
- Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy vol.9, pp.9, 2012, https://doi.org/10.3390/biomedicines9091077
- HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights vol.13, pp.24, 2012, https://doi.org/10.3390/cancers13246280
- “Attractive/adhesion force” dual-regulatory nanogels capable of CXCR4 antagonism and autophagy inhibition for the treatment of metastatic breast cancer vol.341, pp.None, 2022, https://doi.org/10.1016/j.jconrel.2021.12.026