Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes

  • Kim, Kyoung Soo (East-West Bone and Joint Research Institute, Kyung Hee University Hospital at Gangdong) ;
  • Oh, Da Hee (Department of Endocrinology, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Jung Yeon (Department of Pathology, Inje University Sanggye Paik Hospital) ;
  • Lee, Bong Gn (Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine) ;
  • You, Jeong Soon (Department of Food and Nutrition, Inha University) ;
  • Chang, Kyung Ja (Department of Food and Nutrition, Inha University) ;
  • Chung, Hyunju (Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine) ;
  • Yoo, Myung Chul (East-West Bone and Joint Research Institute, Kyung Hee University Hospital at Gangdong) ;
  • Yang, Hyung-In (East-West Bone and Joint Research Institute, Kyung Hee University Hospital at Gangdong) ;
  • Kang, Ja-Heon (Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine) ;
  • Hwang, Yoo Chul (Department of Endocrinology, Kyung Hee University Hospital at Gangdong) ;
  • Ahn, Kue Jeong (Department of Endocrinology, Kyung Hee University Hospital at Gangdong) ;
  • Chung, Ho-Yeon (Department of Endocrinology, Kyung Hee University Hospital at Gangdong) ;
  • Jeong, In-Kyung (Department of Endocrinology, Kyung Hee University Hospital at Gangdong)
  • Accepted : 2012.08.08
  • Published : 2012.11.30
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Abstract

This study aimed to determine whether taurine supplementation improves metabolic disturbances and diabetic complications in an animal model for type 2 diabetes. We investigated whether taurine has therapeutic effects on glucose metabolism, lipid metabolism, and diabetic complications in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term duration of diabetes. Fourteen 50-week-old OLETF rats with chronic diabetes were fed a diet supplemented with taurine (2%) or a non-supplemented control diet for 12 weeks. Taurine reduced blood glucose levels over 12 weeks, and improved OGTT outcomes at 6 weeks after taurine supplementation, in OLETF rats. Taurine significantly reduced insulin resistance but did not improve ${\beta}$-cell function or islet mass. After 12 weeks, taurine significantly decreased serum levels of lipids such as triglyceride, cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol. Taurine significantly reduced serum leptin, but not adiponectin levels. However, taurine had no therapeutic effect on damaged tissues. Taurine ameliorated hyperglycemia and dyslipidemia, at least in part, by improving insulin sensitivity and leptin modulation in OLETF rats with long-term diabetes. Additional study is needed to investigate whether taurine has the same beneficial effects in human diabetic patients.

Keywords

References

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