The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Pear Extracts Containing Herbal Medicine (Lycii Fructus, Coicis Semen, Alimatis Rhizoma, and Astragali Radix) on Body Weight, Lipid Metabolism, and Immune Responses of Rats Fed with High Fat Diets ( I )

배추출물과 구기자, 의이인, 택사, 황기 배합이 고지방식이로 유발된 비만 흰쥐의 체중, 지질대사 및 면역기능에 미치는 영향 ( I )

  • Kim, Wang-In (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Youn, Dae-Hwan (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Kim, Hwang-Gon (Najubedoly) ;
  • Na, Chang-Su (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University)
  • 김왕인 (동신대학교 한의과대학 경혈학교실) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 김황곤 (나주배돌이(영)) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실)
  • Received : 2012.04.18
  • Accepted : 2012.04.25
  • Published : 2012.05.30
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Abstract

Objective : This study was conducted to observe the anti-hyperlipidemic and anti-inflammatory effects, as well as the metabolic benefits, of pear extract and herbal drug mixture (Lycii Fructus, Coicis Semen, Alimatis Rhizoma, and Astragali Radix) on rats fed with a high fat diet. Methods : The animals used were male rats and the control group was fed a high fat diet only. The experimental groups were divided into four. Exp I group was fed a high fat diet with a mixture of pear extract and 3% Lycii Fructus; Exp II group was fed a high fat diet with a mixture of pear extract and 3% Coicis Semen; Exp III group was fed a high fat diet with a mixture of pear extract and 3% Alimatis Rhizoma; and Exp IV group was fed a high fat diet with a mixture of pear extract and 3% Astragali Radix for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in Exp I and Exp III groups than the control group. The concentrations of serum total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, and triglyceride (TG) were significantly higher in Exp II than in the control group, and lower in Exp III group than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp III group than in the control group. In inflammatory activities, the Exp II group was significantly lower than the control group. Conclusion : The results indicated that Exp III group (administered a mixture of pear extract and Alimatis Rhizoma) most efficiently reduced fat accumulation and body weight, while the Exp II group (administered the mixture of pear extract and Coicis Semen) had the highest elevated lipid metabolism and immune activity.

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References

  1. Korean society for the study of obesity. Diagnosis and treatment of obesity. Seoul : Korea medicine. 2003 : 83.
  2. Jeong SH. Obesity research on how to obtain relevant information. J Ori Rehab Med. 1998 ; 8(2) : 1-15.
  3. Kopelman PG. Obesity as a medical problem. Nature. 2000 ; 404(6778) : 635-43.
  4. Department of Internal Medicine, Collage of medicine, Seoul University. Internal medicine. Seoul : Kunja company. 1996 : 852-62.
  5. Gwakaechun. Canon of Medicine. Tianjin : Tianjin Science and Technology Publishing. 1981 : 54, 87, 183, 194, 282.
  6. Heo SY. Oriental and Western Medical Study on the investigation and treatment of Obesity. J Ori Rehab Med. 1997 ; 7(1) : 272-86.
  7. Sung YY, Yoon T, Kim SJ, Yang WK, Kim HK. Anti-obesity activity of Allium fistulosum L. extract by down-regulation of the expression of lipogenic genes in high-fat diet-induced obese mice. Mol Med Report. 2011 ; 4(3) : 431-5.
  8. Sung YY, Yoon T, Yang WK, Kim SJ, Kim HK. Anti-obesity effects of Geranium thunbergii extract via improvement of lipid metabolism in high-fat diet-induced obese mice. Mol Med Report. 2011 ; 4(6) : 1107-13.
  9. Niu C, Chen C, Chen L, Cheng K, Yeh C, Cheng J. Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPAR$\alpha$ in liver of mice fed high-fat diet. Horm Metab Res. 2011 ; 43(9) : 625-30. https://doi.org/10.1055/s-0031-1283147
  10. Yamamoto N, Kanemoto Y, Ueda M, Kawasaki K, Fukuda I, Ashida H. Anti-obesity and anti-diabetic effects of ethanol extract of Artemisia princeps in C57BL/6 mice fed a high-fat diet. Food Funct. 2011 ; 2(1) : 45-52. https://doi.org/10.1039/c0fo00129e
  11. Lai P, Du JR, Zhang MX, Kuang X, Li YJ, Chen YS, He Y. Aqueous extract of Gleditsia sinensis Lam. fruits improves serum and liver lipid profiles and attenuates atherosclerosis in rabbits fed a high-fat diet. J Ethnopharmacol. 2011 ; 137(3) : 1061-6. https://doi.org/10.1016/j.jep.2011.06.023
  12. Yoon KR. Biological effects of Allium monanthum extracts on the lipid metabolism, anti-oxidation and pro-inflammatory cytokines production in rat fed high fat diet. Sangji University Graduate School. 2011.
  13. Park WH. Effects of stem bark extracts of Cornus walteri Wanger on the lipid lowering, anti-oxidative activity and concentration of proinflammatory cytokines in rat fed high fat diet. Sangji University Graduate School. 2009.
  14. Kong IP. Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in High Fat Diet Induced Obese Rats. Sangji University Graduate School. 2011.
  15. Oh SW. Effects of Jowiseungcheung-tang(JWSCT) extract on the lipid metabolism, anti-oxidation and inflammatory response in obesity rat fed high fat diet. Sangji University Graduate School. 2011.
  16. Jingyujeong. Explain of BenCaoGangMu(本草綱目通釋), Beijing : Hakwon company. 1992 : 1449-50.
  17. Na CS, Youn DH, Choi DH, Jeong JG, Eun JB, Kim JS. The Effect of Pear Pectin &. Phenolic Compounds on Regional Cerebral Blood Flow, Mean Arterial Blood Pressure, Heart Rate and Cardiac Contractile Force in Hypertensive Rat Induced by 2K1C. Kor J herbology. 2003 ; 18(2) : 101-8.
  18. Na CS, Youn DH, Choi DH, Kim JS, Cao CH, Eun JB. The Effect of Pear Pectin on Blood Pressure, Plasma Renin, ANP and Cardiac Hypertrophy in Hypertensive Rat Induced by 2K1C. J Korean Soc Food Sci Nutr. 2003 ; 32(5) : 700-5. https://doi.org/10.3746/jkfn.2003.32.5.700
  19. Jeong-Sang Kim, Chang Su Na. Effect of Rehmanniae Radix and Pear Phenolic Compound on the STZ-Treated Mice for Induction of Diabetes. J Kor Soc Food Sci Nutr. 2004 ; 33(1) : 66-71. https://doi.org/10.3746/jkfn.2004.33.1.066
  20. Choi ch, Youn DH, Kim JH, Jeong JG, Na CS. The Effects of Pear Phenolic Compound and Herbal Drugs According to the dose and Duration on the Respiratory System of Asthma Mice Induced by Ovalbumin. Kor J herbology. 2008 ; 23(4) : 135-47.
  21. Lee JC, Pak SC, Lee SH, Na CS, Lim SC, Song CH, Bai YH, Jang CH. Asian pear pectin administration during presensitization inhibits allergic response to ovalbumin in BALB/c mice. J Altern Complement Med. 2004 ; 10(3) : 527-34. https://doi.org/10.1089/1075553041323867
  22. Jang DY. Textbook of Obesity and body contouring. MD world medical book Co Ltd. 2011: 35-107.
  23. George A Bray. Office management of Obesity hanmi-medicine. 2004 : 35-59, 108-25.
  24. Park SH. Development of Yak-Sun for Excess Syndrome Obesity (1) Effects of Weight, Serum Glucose, Insulin and Lipid Profiles of Oriental Medicinal Herbs with Removal of Dampness through Diuresis. J east Asian Soc Dietary Life. 2005 ; 15(6) : 700-6.
  25. Nemoto Y, Torizuka K, Ida Y. Shokan-kinki Yakubutsu Jiten jisangsa. 2011 : 141-3, 172, 179-81, 197-8.
  26. Charakida M, Finer N. Drug treatment of obesity in cardiovascular disease. Am J Cardiovasc Drugs. 2012 ; 12(2) : 93-104. https://doi.org/10.2165/11599000-000000000-00000
  27. Seo DM, Lee SH, Lee JD. Clinical Observation on Effects and Adverse Effects of Choweseuncheng -tang on Obesity Patients. J Kor Acupunc Moxib Soc. 2005 ; 22(3) : 145-53.

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