The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Tong Xin Lou (TXL) on levels of serum lipid in high fat diet-induced dyslipidemia in mice

통심락(通心絡)이 고지방식이로 유도된 이상지질혈증 생쥐의 체내 지질 변화에 미치는 영향

  • Ha, Tae-Hoon (College of Oriental Medicine, Dongeui University) ;
  • Kim, Hyun-Young (College of Oriental Medicine, Dongeui University) ;
  • Kim, Hyung-Woo (School of Korean medicine, Pusan National University) ;
  • Cho, Su-In (School of Korean medicine, Pusan National University) ;
  • Kim, Young-Gyun (College of Oriental Medicine, Dongeui University)
  • 하태훈 (동의대학교 한의과대학) ;
  • 김현영 (동의대학교 한의과대학) ;
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 조수인 (부산대학교 한의학전문대학원) ;
  • 김영균 (동의대학교 한의과대학)
  • Received : 2012.04.03
  • Accepted : 2012.04.24
  • Published : 2012.05.30
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Abstract

Objectives : This study was designed to investigate the effects of Tong Xin Lou (TXL) on lipid accumulation in liver tissue in Hypercholesterolemic mice. TXL is new drug, which is one of Cardiotonic Pills. TXL is used for activating the blood flow in the restoration stage of cerebral infarction, and for alleviation of angina pectoris including the symptoms as chest oppressed and stabbing pain. Methods : Hyperlipidemia was induced by providing high fat diet for 6 weeks. Normal group was provided with normal rodent diet. TXL was administered orally in the concentration of 10 mg/day for 2 weeks (TXL group). D/W was administered orally in CTL group for 2 weeks. We observed histopathological changes in liver and heart tissues, and also investigated the effect on body weights, and levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride in serum. Results : In this study, TXL did not affects weight gain in hypercholesterolemic mice. TXL group showed downward tendency of lipid accumulation compared with CTL group. In addition, oral administration of TXL lowered levels of total cholesterol (P < 0.05) and triglyceride (P < 0.05), which were elevated by induction of hypercholesterolemia. Conclusion : These results suggest that TXL can prevent lipid accumulation in liver tissue through regulation of dyslipidemia.

Keywords

References

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