Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Expression of Tumor Necrosis Factor-alpha-induced Protein 8 in Pancreas Tissues and its Correlation with Epithelial Growth Factor Receptor Levels

  • Liu, Ke (Department of Hepatobiliary, Provincial Hospital affiliated to Shandong University) ;
  • Qin, Cheng-Kun (Department of Hepatobiliary, Provincial Hospital affiliated to Shandong University) ;
  • Wang, Zhi-Yi (Department of Hepatobiliary, Provincial Hospital affiliated to Shandong University) ;
  • Liu, Su-Xia (Department of immunology, Shandong University School of Medicine) ;
  • Cui, Xian-Ping (Department of Hepatobiliary, Provincial Hospital affiliated to Shandong University) ;
  • Zhang, Dong-Yuan (Department of Hepatobiliary, Provincial Hospital affiliated to Shandong University)
  • Published : 2012.03.31
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Abstract

Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) is a recently identified protein considered to be associated with carcinogenesis. To investigate its expression pattern in pancreatic cancer patients and to analyse its correlation with clinicopathological significance and the expression levels of epithelial growth factor receptor (EGFR), immunohistochemistry was performed to detect the TNFAIP8 and EGFR proteins in pancreatic cancers, pancreatitis tissues, and healthy controls. The results showed stronger staining of TNFAIP8 protein in pancreatic cancer tissues compared with normal pancreas tissue. Furthermore, in 56 patients with pancreatic cancer, the expression levels of TNFAIP8 in patients with low tumor stage was higher than that with high tumor stage, and correlated with tumor staging and lymph node metastasis (P<0.05). Furthermore, TNFAIP8 expression positively correlated with EGFR levels (r=0.671135, P<0.05). These results indicate that TNFAIP8 may play important roles in the progression of pancreatic cancer.

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References

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