Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Study on Soy Isoflavone Consumption and Risk of Breast Cancer and Survival

  • Kang, Hong-Bin (Department of General Surgery, The First Affiliated Hospital of inner Mongolia Medical College) ;
  • Zhang, Ya-Feng (Department of General Surgery, The First Affiliated Hospital of inner Mongolia Medical College) ;
  • Yang, Jin-Dun (The Hospital of Damao county) ;
  • Lu, Kuan-Liang (The Hospital of Damao county)
  • Published : 2012.03.31
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Abstract

Aim: Isoflavones in soy foods are part of a larger class of flayonoid compounds that have have been demonstrated to be potent dietary anti-cancer agents, and the effect of soy intake on the survival of ovarian cancer is conflicting. Therefore, we aimed to explore the whether soy intake is related to the risk of death of breast cancer. Methods: A prospective study was conducted. A total of 256 patients included in this study had breast cancer and were recruited between January 2004 and January 2006. All of them were followed up from since January 2011. A univariate Cox's regression analysis was used to assess the association between soy intake and survival. Results: The education level, menopausal status, ER/PR status and TNM stage were significant difference in the survival of breast cancer. The highest soy isoflavone was associated with a decreased death risk of breast cancer (OR=0.25, 95% CI=0.09-0.54). Moreover, the higher consumption of soy protein also presented a trend decreased breast cancer risk, and the highest consumption significantly reduced the cancer risk compared with the lowest consumption (OR=0.38, 95% CI=0.17-0.86). Conclusion: The present study suggests soy intake is associated with a significant reduced death risk of breast cancer in Chinese population. Further large sample studies are warranted to confirm the inverse association of soy consumption and breast cancer survival by menopausal status.

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References

  1. Cassidy A, Bingham S, Setchell KD (1994). Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr, 60, 333-40. https://doi.org/10.1093/ajcn/60.3.333
  2. Constantinou AI, White BE, Tonetti D, et al (2005). The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours. Eur J Cancer, 41, 647-54. https://doi.org/10.1016/j.ejca.2004.12.005
  3. Curado MP, Edwards B, Shin HR, et al (eds) (2007). Cancer incidence in five continents No. 160. IARC Scientific Publications, Lyon.
  4. Dong JY, Qin LQ (2011). Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat, 125, 315-23. https://doi.org/10.1007/s10549-010-1270-8
  5. Harris PF, Remington PL, Trentham-Dietz A, Allen CI, Newcomb PA (2002). Prevalence and treatment of menopausal symptoms among breast cancer survivors. J Pain Symptom Manage, 23, 501-9. https://doi.org/10.1016/S0885-3924(02)00395-0
  6. Kaur JS (2000). Migration patterns and breast carcinoma. Cancer, 88, 1203-6. https://doi.org/10.1002/(SICI)1097-0142(20000301)88:5+<1203::AID-CNCR4>3.0.CO;2-#
  7. Korde LA, Wu AH, Fears T, et al (2009). Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev, 18, 1050-9. https://doi.org/10.1158/1055-9965.EPI-08-0405
  8. Lu LJ, Anderson KE, Grady JJ, Nagamani M (1996). Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epidemiol Biomarkers Prev, 5, 63-70.
  9. Messina M, McCaskill-Stevens W, Lampe JW (2006). Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. J Natl Cancer Inst, 98, 1275-84. https://doi.org/10.1093/jnci/djj356
  10. Mitchell JH, Gardner PT, McPhail DB, et al (1998). Antioxidant efficacy of phytoestrogens in chemical and biological model systems. Arch Biochem Biophys, 360, 142-8. https://doi.org/10.1006/abbi.1998.0951
  11. Morris KT, Johnson N, Homer L, Walts D (2000). A comparison of complementary therapy use between breast cancer patients and patients with other primary tumor sites. Am J Surg, 179, 407-11. https://doi.org/10.1016/S0002-9610(00)00358-5
  12. Murphy PA, Song T, Buseman G, et al (1999). Isoflavones in retail and institutional soy foods. J Agric Food Chem, 47, 2697-704. https://doi.org/10.1021/jf981144o
  13. Parkin DM (1989). Cancers of the breast, endometrium and ovary: geographic correlations. Eur J Cancer Clin Oncol, 25, 1917-25. https://doi.org/10.1016/0277-5379(89)90373-8
  14. Parkin DM, Khlat M (1996). Studies of cancer in migrants: rationale and methodology. Eur J Cancer, 32A,761-71.
  15. Reinli K, Block G (1996). Phytoestrogen content of foods-a compendium of literature values. Nutr Cancer, 26, 123-48. https://doi.org/10.1080/01635589609514470
  16. Rose DP, Boyar AP, Wynder EL (1986). International comparisons of mortality rates for cancer of the breast, ovary, prostate and colon, and per capita food consumption. Cancer, 58, 2363-71. https://doi.org/10.1002/1097-0142(19861201)58:11<2363::AID-CNCR2820581102>3.0.CO;2-#
  17. Shu XO, Jin F, Dai Q, et al (2001). Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev, 10, 483-8.
  18. Stanford JL, Herrinton LJ, Schwartz SM, Weiss NS (1995). Breast cancer incidence in Asian migrants to the United States and their descendants. Epidemiology, 6, 181-3. https://doi.org/10.1097/00001648-199503000-00017
  19. Thanos J, Cotterchio M, Boucher BA, et al (2006). Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). Cancer Causes Control, 17, 1253-61. https://doi.org/10.1007/s10552-006-0062-2
  20. Trichopoulos D, Yen S, Brown J, Cole P, MacMahon B (1984). The effect of westernization on urine estrogens, frequency of ovulation, and breast cancer risk. A study of ethnic Chinese women in the Orient and the USA. Cancer, 53, 187-92. https://doi.org/10.1002/1097-0142(19840101)53:1<187::AID-CNCR2820530133>3.0.CO;2-N
  21. Wu AH, Wan P, Hankin J, et al (2002). Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis, 23, 1491-6. https://doi.org/10.1093/carcin/23.9.1491
  22. Ziegler RG, Hoover RN, Pike MC, et al (1993). Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst, 85, 1819-27. https://doi.org/10.1093/jnci/85.22.1819

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