Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Ailanthoidol Derivatives and their Anti-inflammatory Effects

  • Lee, Na-Li (Department of Chemistry and Institute of Natural Medicine, Hallym University) ;
  • Lee, Jae-Jun (Department of Chemistry and Institute of Natural Medicine, Hallym University) ;
  • Kim, Jin-Kyung (Department of Biomedical Science, College of Natural Science, Catholic University of Daegu) ;
  • Jun, Jong-Gab (Department of Chemistry and Institute of Natural Medicine, Hallym University)
  • Received : 2012.01.20
  • Accepted : 2012.03.07
  • Published : 2012.06.20
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Abstract

Ailanthoidol showed a strong $anti$-inflammatory effect in a previous result. Ailanthoidol derivatives were prepared for the $anti$-inflammatory test using Sonogashira coupling, iodine induced cyclization and Wittig reaction. $Anti$-inflammatory effects of the prepared ailanthoidol derivatives were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that some ailanthoidol derivatives inhibited significantly the production of inflammatory mediator nitric oxide.

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References

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