Laboraroty Animal Research

Korean Association for Laboratory Animal Science (한국실험동물학회)
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Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice

  • Published : 2012.06.30
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Abstract

The solution fermented by bacillus subtilis MORI (BTD-1E) in purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution (BTD-1E) fermented by Bacillus subtilis MORI in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model.

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References

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