Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

The Effects of Astragali Radix Pharmacopuncture at $CV_{12}$ on Osteoporosis of Senescence Accelerated Mice (SAM) P6

중완(中脘)($CV_{12}$) 황기약침이 노화촉진 생쥐의 골다공증 개선에 미치는 영향

  • Kim, Sung-Phil (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Kim, Seung-Man (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Ryu, Hye-Seon (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Shin, Jeong-Cheol (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Lee, Dong-Geun (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Lee, Ook-Jae (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Lee, Ju-Hee (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Kim, Jae-Hong (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University)
  • 김성필 (동신대학교 한의과대학 침구의학교실) ;
  • 김승만 (동신대학교 한의과대학 침구의학교실) ;
  • 류혜선 (동신대학교 한의과대학 침구의학교실) ;
  • 신정철 (동신대학교 한의과대학 침구의학교실) ;
  • 이동근 (동신대학교 한의과대학 침구의학교실) ;
  • 이욱재 (동신대학교 한의과대학 침구의학교실) ;
  • 이주희 (동신대학교 한의과대학 침구의학교실) ;
  • 김재홍 (동신대학교 한의과대학 침구의학교실)
  • Received : 2012.04.12
  • Accepted : 2012.04.14
  • Published : 2012.04.20
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Abstract

Objectives : The purpose of this study was to examine the effects of the Astragali radix Pharmacopuncture on improvement of senile osteoporosis (Type 2) in SAM P6. Methods : At 10 weeks after birth, Astragali radix Pharmacopunctures were given 100mL, 200mL/kg/day, i.p. 3times a week for 4 weeks at $CV_{12}$ in SAM P6 mice. We measured complete blood cells (CBC) such as RBC, HGB, Hct, PLT, MPB and MCHC. And we analyzed the plasma concentrations of blood urea nitrogen, creatinine, inorganic phosphate and total iron. In addition, we tested bone mineral density (BMD) using the soft X-ray. Results : The results were as follows. 1. At $CV_{12}$ in SAM P6, treatments of Astragali radix Pharmacopuncture were showed a trend of increase in bone mineral density (BMD) of the vertebrae lumbales, femurand tibia in P6 mice. 2. At $CV_{12}$ in SAM P6, treatment of Astragali radix Pharmacopuncture increased in RBC, HB, HCT and PLT, in comparison with control group. It was also found that the inorganic phosphate levels increased in the treatment on groups of the Astragali radix Pharmacopuncture from that of the control group, but blood urea nitrogen was no significant. Conclusions : These results are suggested that at $CV_{12}$ the Astragali radix Pharmacopuncture help on improvement of osteoporosis in SAMs.

Keywords

References

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