Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Pharmacological and Toxicological review of Yukmijihwang-tang(Hwan)

육미지황탕(환)의 약리와 독성에 대한 문헌고찰

  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu) ;
  • Kim, Jong-Bong (Dept. of Medicinal life science, Catholic University of Daegu) ;
  • Kook, Yoon-Boom (Dept. of Formula Science, School of Oriental Medicine, Sang-Ji University) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sang-Ji University)
  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 김종봉 (대구가톨릭대학교 의생명과학과) ;
  • 국윤범 (상지대학교 한의과대학 방제학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2012.05.07
  • Accepted : 2012.06.11
  • Published : 2012.06.30
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Abstract

Objectives : Yukmijihwang-tang(Wan), a well-known formula for invigorating yin-particular kidney yin, was first recorded in "Xiao er Yao Zheng Zhi Jue", consisting of Radix Rehmanniae Preparata, Fructus Macrocarpii, Rhizoma Dioscoreae Oppositae, Poria, Rhizoma Alismatis and Cortex Moutan Radicis with dose proportion of 8:4:4:3:3:3. Although clinical trials have been lacking, various pharmacological actions for Yukmijihwang-tang has been identified newly using animal models. In addition, it was reported that Yukmijihwang-tang increases structural chromosome aberrations significantly in Chinese hamster lung cells. In this article, it is purposed that new studies for pharmacology and toxicology of Yukmijihwang-tang are reviewed. Insight into new studies of Yukmijihwang-tang at the cellular and animal levels will enhance our understanding of Yukmijihwang-tang against various diseases will provide new tools to diagnose and treat patients. Methods : Recent researches for Yukmijihwang-tang were reviewed and summarized in terms of pharmacological action and toxicity. All sources for review were based on recent studies loaded on data base of web sites such as Science Direct and National Center for Biotechnology Information. Results and Conclusions : Recently, reports showed that YMJ had antiaging effects, antioxidant and free radical scavenging activities, anti-renal hypertension and prevented tumors, and diabetes mellitus. However, there is little information on its safety except general toxicity, acute and sub-chronic oral toxicity, or genotoxicity. In addition, clinical trial for Yukmijihwang-tang was limited even though Yukmijihwang-tang has been used extensively in Korean traditional medicine. Thus, further studies are necessary to focus on safety evaluation and clinical trial for Yukmijihwang-tang.

Keywords

References

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