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Spinal Cord Stimulation in Pain Management: A Review

  • Jeon, Young-Hoon (Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University)
  • Received : 2012.06.01
  • Accepted : 2012.06.08
  • Published : 2012.07.01

Abstract

Spinal cord stimulation has become a widely used and efficient alternative for the management of refractory chronic pain that is unresponsive to conservative therapies. Technological improvements have been considerable and the current neuromodulation devices are both extremely sophisticated and reliable in obtaining good results for various clinical situations of chronic pain, such as failed back surgery syndrome, complex regional pain syndrome, ischemic and coronary artery disease. This technique is likely to possess a savings in costs compared with alternative therapy strategies despite its high initial cost. Spinal cord stimulation continues to be a valuable tool in the treatment of chronic disabling pain.

Keywords

References

  1. Melzack R, Wall PD. Pain mechanisms: a new theory. Science 1965; 150: 971-9. https://doi.org/10.1126/science.150.3699.971
  2. Shealy CN, Mortimer JT, Reswick JB. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. Anesth Analg 1967; 46: 489-91.
  3. Burchiel KJ, Anderson VC, Wilson BJ, Denison DB, Olson KA, Shatin D. Prognostic factors of spinal cord stimulation for chronic back and leg pain. Neurosurgery 1995; 36: 1101-10. https://doi.org/10.1227/00006123-199506000-00006
  4. North RB. Psychological criteria are outcome measures as well as prognostic factors. Pain Forum 1996; 5: 111-4. https://doi.org/10.1016/S1082-3174(96)80045-6
  5. Kemler MA, Barendse GA, van Kleef M, de Vet HC, Rijks CP, Furnée CA, et al. Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy. N Engl J Med 2000; 343: 618-24. https://doi.org/10.1056/NEJM200008313430904
  6. Barolat G. Spinal cord stimulation for chronic pain management. Arch Med Res 2000; 31: 258-62. https://doi.org/10.1016/S0188-4409(00)00075-8
  7. Kemler MA, Raphael JH, Bentley A, Taylor RS. The costeffectiveness of spinal cord stimulation for complex regional pain syndrome. Value Health 2010; 13: 735-42. https://doi.org/10.1111/j.1524-4733.2010.00744.x
  8. Hornberger J, Kumar K, Verhulst E, Clark MA, Hernandez J. Rechargeable spinal cord stimulation versus non-rechargeable system for patients with failed back surgery syndrome: a cost-consequences analysis. Clin J Pain 2008; 24: 244-52. https://doi.org/10.1097/AJP.0b013e318160216a
  9. Cui JG, Meyerson BA, Sollevi A, Linderoth B. Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABA(B) and adenosine receptor activation. Neurosci Lett 1998; 247: 183-6. https://doi.org/10.1016/S0304-3940(98)00324-3
  10. Dubuisson D. Effect of dorsal-column stimulation on gelatinosa and marginal neurons of cat spinal cord. J Neurosurg 1989; 70: 257-65. https://doi.org/10.3171/jns.1989.70.2.0257
  11. Stiller CO, Cui JG, O'Connor WT, Brodin E, Meyerson BA, Linderoth B. Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery 1996; 39: 367-74. https://doi.org/10.1097/00006123-199608000-00026
  12. Linderoth B, Gazelius B, Franck J, Brodin E. Dorsal column stimulation induces release of serotonin and substance P in the cat dorsal horn. Neurosurgery 1992; 31: 289-96. https://doi.org/10.1227/00006123-199208000-00014
  13. Ren B, Linderoth B, Meyerson BA. Effects of spinal cord stimulation on the flexor reflex and involvement of supraspinal mechanisms: an experimental study in mononeuropathic rats. J Neurosurg 1996; 84: 244-9. https://doi.org/10.3171/jns.1996.84.2.0244
  14. Meyerson BA, Ren B, Herregodts P, Linderoth B. Spinal cord stimulation in animal models of mononeuropathy: effects on the withdrawal response and the flexor reflex. Pain 1995; 61: 229-43. https://doi.org/10.1016/0304-3959(94)00171-A
  15. Larson SJ, Sances A Jr, Riegel DH, Meyer GA, Dallmann DE, Swiontek T. Neurophysiological effects of dorsal column stimulation in man and monkey. J Neurosurg 1974; 41: 217-23. https://doi.org/10.3171/jns.1974.41.2.0217
  16. Bantli H, Bloedel JR, Thienprasit P. Supraspinal interactions resulting from experimental dorsal column stimulation. J Neurosurg 1975; 42: 296-300. https://doi.org/10.3171/jns.1975.42.3.0296
  17. Oakley JC, Prager JP. Spinal cord stimulation: mechanisms of action. Spine (Phila Pa 1976) 2002; 27: 2574-83. https://doi.org/10.1097/00007632-200211150-00034
  18. Linderoth B, Fedorcsak I, Meyerson BA. Peripheral vasodilatation after spinal cord stimulation: animal studies of putative effector mechanisms. Neurosurgery 1991; 28: 187-95. https://doi.org/10.1227/00006123-199102000-00003
  19. Linderoth B, Herregodts P, Meyerson BA. Sympathetic mediation of peripheral vasodilation induced by spinal cord stimulation: animal studies of the role of cholinergic and adrenergic receptor subtypes. Neurosurgery 1994; 35: 711-9. https://doi.org/10.1227/00006123-199410000-00018
  20. Holsheimer J, Wesselink WA. Optimum electrode geometry for spinal cord stimulation: the narrow bipole and tripole. Med Biol Eng Comput 1997; 35: 493-7. https://doi.org/10.1007/BF02525529
  21. Oakley JC, Espinosa F, Bothe H, McKean J, Allen P, Burchiel K, et al. Transverse tripolar spinal cord stimulation: results of an international multicenter study. Neuromodulation 2006; 9: 192-203. https://doi.org/10.1111/j.1525-1403.2006.00060.x
  22. Chincholkar M, Eldabe S, Strachan R, Brookes M, Garner F, Chadwick R, et al. Prospective analysis of the trial period for spinal cord stimulation treatment for chronic pain. Neuromodulation 2011; 14: 523-8. https://doi.org/10.1111/j.1525-1403.2011.00384.x
  23. Taylor RS, Van Buyten JP, Buchser E. Spinal cord stimulation for chronic back and leg pain and failed back surgery syndrome: a systematic review and analysis of prognostic factors. Spine (Phila Pa 1976) 2005; 30: 152-60. https://doi.org/10.1097/01.brs.0000149199.68381.fe
  24. North RB, Kidd DH, Farrokhi F, Piantadosi SA. Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain: a randomized, controlled trial. Neurosurgery 2005; 56: 98-106. https://doi.org/10.1227/01.NEU.0000144839.65524.E0
  25. North RB, Ewend MG, Lawton MT, Kidd DH, Piantadosi S. Failed back surgery syndrome: 5-year follow-up after spinal cord stimulator implantation. Neurosurgery 1991; 28: 692-9. https://doi.org/10.1227/00006123-199105000-00009
  26. Kumar K, Taylor RS, Jacques L, Eldabe S, Meglio M, Molet J, et al. Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicentre randomised controlled trial in patients with failed back surgery syndrome. Pain 2007; 132: 179-88. https://doi.org/10.1016/j.pain.2007.07.028
  27. Kemler MA, De Vet HC, Barendse GA, Van Den Wildenberg FA, Van Kleef M. The effect of spinal cord stimulation in patients with chronic reflex sympathetic dystrophy: two years' follow-up of the randomized controlled trial. Ann Neurol 2004; 55: 13-8. https://doi.org/10.1002/ana.10996
  28. Kemler MA, de Vet HC, Barendse GA, van den Wildenberg FA, van Kleef M. Effect of spinal cord stimulation for chronic complex regional pain syndrome Type I: five-year final follow-up of patients in a randomized controlled trial. J Neurosurg 2008; 108: 292-8. https://doi.org/10.3171/JNS/2008/108/2/0292
  29. Stanton-Hicks M. Complex regional pain syndrome: manifestations and the role of neurostimulation in its management. J Pain Symptom Manage 2006; 31(4 Suppl): S20-4. https://doi.org/10.1016/j.jpainsymman.2005.12.011
  30. Murphy DF, Giles KE. Dorsal column stimulation for pain relief from intractable angina pectoris. Pain 1987; 28: 365-8. https://doi.org/10.1016/0304-3959(87)90070-4
  31. Murray S, Carson KG, Ewings PD, Collins PD, James MA. Spinal cord stimulation significantly decreases the need for acute hospital admission for chest pain in patients with refractory angina pectoris. Heart 1999; 82: 89-92. https://doi.org/10.1136/hrt.82.1.89
  32. TenVaarwerk IA, Jessurun GA, DeJongste MJ, Andersen C, Mannheimer C, Eliasson T, et al. Clinical outcome of patients treated with spinal cord stimulation for therapeutically refractory angina pectoris. The Working Group on Neurocardiology. Heart 1999; 82: 82-8. https://doi.org/10.1136/hrt.82.1.82
  33. Mannheimer C, Eliasson T, Augustinsson LE, Blomstrand C, Emanuelsson H, Larsson S, et al. Electrical stimulation versus coronary artery bypass surgery in severe angina pectoris: the ESBY study. Circulation 1998; 97: 1157-63. https://doi.org/10.1161/01.CIR.97.12.1157
  34. Andréll P, Yu W, Gersbach P, Gillberg L, Pehrsson K, Hardy I, et al. Long-term effects of spinal cord stimulation on angina symptoms and quality of life in patients with refractory angina pectoris--results from the European Angina Registry Link Study (EARL). Heart 2010; 96: 1132-6. https://doi.org/10.1136/hrt.2009.177188
  35. Neri Serneri GG, Boddi M, Arata L, Rostagno C, Dabizzi P, Coppo M, et al. Silent ischemia in unstable angina is related to an altered cardiac norepinephrine handling. Circulation 1993; 87: 1928-37. https://doi.org/10.1161/01.CIR.87.6.1928
  36. McCance AJ, Thompson PA, Forfar JC. Increased cardiac sympathetic nervous activity in patients with unstable coronary heart disease. Eur Heart J 1993; 14: 751-7. https://doi.org/10.1093/eurheartj/14.6.751
  37. Norrsell H, Eliasson T, Mannheimer C, Augustinsson LE, Bergh CH, Andersson B, et al. Effects of pacing-induced myocardial stress and spinal cord stimulation on whole body and cardiac norepinephrine spillover. Eur Heart J 1997; 18: 1890-6. https://doi.org/10.1093/oxfordjournals.eurheartj.a015197
  38. Foreman RD, Linderoth B, Ardell JL, Barron KW, Chandler MJ, Hull SS Jr, et al. Modulation of intrinsic cardiac neurons by spinal cord stimulation: implications for its therapeutic use in angina pectoris. Cardiovasc Res 2000; 47: 367-75. https://doi.org/10.1016/S0008-6363(00)00095-X
  39. Murray S, Collins PD, James MA. Neurostimulation treatment for angina pectoris. Heart 2000; 83: 217-20. https://doi.org/10.1136/heart.83.2.217
  40. Cook AW, Oygar A, Baggenstos P, Pacheco S, Kleriga E. Vascular disease of extremities. Electric stimulation of spinal cord and posterior roots. N Y State J Med 1976; 76: 366-8.
  41. Amann W, Berg P, Gersbach P, Gamain J, Raphael JH, Ubbink DT, et al. Spinal cord stimulation in the treatment of non-reconstructable stable critical leg ischaemia: results of the European Peripheral Vascular Disease Outcome Study (SCS-EPOS). Eur J Vasc Endovasc Surg 2003; 26: 280-6. https://doi.org/10.1053/ejvs.2002.1876
  42. Jivegård LE, Augustinsson LE, Holm J, Risberg B, Ortenwall P. Effects of spinal cord stimulation (SCS) in patients with inoperable severe lower limb ischaemia: a prospective randomised controlled study. Eur J Vasc Endovasc Surg 1995; 9: 421-5. https://doi.org/10.1016/S1078-5884(05)80010-3
  43. Claeys LG, Horsch S. Transcutaneous oxygen pressure as predictive parameter for ulcer healing in endstage vascular patients treated with spinal cord stimulation. Int Angiol 1996; 15: 344-9.
  44. Klomp HM, Spincemaille GH, Steyerberg EW, Habbema JD, van Urk H. Spinal-cord stimulation in critical limb ischaemia: a randomised trial. ESES Study Group. Lancet 1999; 353: 1040-4. https://doi.org/10.1016/S0140-6736(98)05069-7
  45. Petrakis IE, Sciacca V. Spinal cord stimulation in critical limb ischemia of the lower extremities: our experience. J Neurosurg Sci 1999; 43: 285-93.
  46. Ubbink DT, Vermeulen H. Spinal cord stimulation for nonreconstructable chronic critical leg ischaemia. Cochrane Database Syst Rev 2005; (3): CD004001.
  47. Horsch S, Claeys L. Epidural spinal cord stimulation in the treatment of severe peripheral arterial occlusive disease. Ann Vasc Surg 1994; 8: 468-74. https://doi.org/10.1007/BF02133067
  48. Pedrini L, Magnoni F. Spinal cord stimulation for lower limb ischemic pain treatment. Interact Cardiovasc Thorac Surg 2007; 6: 495-500. https://doi.org/10.1510/icvts.2006.150185
  49. Spincemaille GH, de Vet HC, Ubbink DT, Jacobs MJ. The results of spinal cord stimulation in critical limb ischaemia: a review. Eur J Vasc Endovasc Surg 2001; 21: 99-105. https://doi.org/10.1053/ejvs.2000.1291
  50. Manca A, Kumar K, Taylor RS, Jacques L, Eldabe S, Meglio M, et al. Quality of life, resource consumption and costs of spinal cord stimulation versus conventional medical management in neuropathic pain patients with failed back surgery syndrome (PROCESS trial). Eur J Pain 2008; 12: 1047-58. https://doi.org/10.1016/j.ejpain.2008.01.014
  51. Yu W, Maru F, Edner M, Hellström K, Kahan T, Persson H. Spinal cord stimulation for refractory angina pectoris: a retrospective analysis of efficacy and cost-benefit. Coron Artery Dis 2004; 15: 31-7. https://doi.org/10.1097/00019501-200402000-00005
  52. Turner JA, Loeser JD, Deyo RA, Sanders SB. Spinal cord stimulation for patients with failed back surgery syndrome or complex regional pain syndrome: a systematic review of effectiveness and complications. Pain 2004; 108: 137-47. https://doi.org/10.1016/j.pain.2003.12.016
  53. Mekhail NA, Mathews M, Nageeb F, Guirguis M, Mekhail MN, Cheng J. Retrospective review of 707 cases of spinal cord stimulation: indications and complications. Pain Pract 2011; 11: 148-53. https://doi.org/10.1111/j.1533-2500.2010.00407.x
  54. Cameron T. Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review. J Neurosurg 2004; 100(3 Suppl Spine): 254-67.
  55. Barolat G. Experience with 509 plate electrodes implanted epidurally from C1 to L1. Stereotact Funct Neurosurg 1993; 61: 60-79. https://doi.org/10.1159/000100624
  56. McDonald M, Grabsch E, Marshall C, Forbes A. Singleversus multiple-dose antimicrobial prophylaxis for major surgery: a systematic review. Aust N Z J Surg 1998; 68: 388-96. https://doi.org/10.1111/j.1445-2197.1998.tb04785.x
  57. Bedder MD, Bedder HF. Spinal cord stimulation surgical technique for the nonsurgically trained. Neuromodulation 2009; 12 Suppl 1: 1-19.
  58. Eldrige JS, Weingarten TN, Rho RH. Management of cerebral spinal fluid leak complicating spinal cord stimulator implantation. Pain Pract 2006; 6: 285-8. https://doi.org/10.1111/j.1533-2500.2006.00097.x

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