The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of KOB, a polyherbal medicine for allergic rhinitis and its main herb, Astragali Radix on allergic responses in OVA-induced Allergic rhinitis mice

알레르기 비염 한약제제 KOB와 주요 구성약물인 황기(黃芪)의 난알부민 유도 알레르기 비염 마우스에서의 항알레르기 효능 연구

  • Kang, Seok-Yong (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Hong, Seung-Ug (Department of Oriental Medicine Ophthalmology & Otolaryngology & Dermatology, College of Oriental Medicine, Dongguk University Ilsan Oriental Hospital) ;
  • Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
  • 강석용 (동국대학교 한의과대학 본초학교실) ;
  • 홍승욱 (동국대학교 일산한방병원 한방이빈인후피부과) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Received : 2012.06.11
  • Accepted : 2012.06.26
  • Published : 2012.07.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : In this study, we investigated the effect of KOB, a polyherbal medicine for allergic rhinitis and its main herb, Astragali Radix on allergic responses in ovalbumin (OVA)-induced Allergic rhinitis(AR) mice. Methods : Sprague Dawley (SD)-rats were orally administrated with KOB (500 mg/kg), Astragali Radix water extract (ARW, 100 mg/kg) or anti-histamine drug, dosodium cromoglycate (50 mg/kg) as a reference drug, and then intraperitoneally injected with compound 48/80 (8 mg/kg). Rats were measured the mortality and serum levels of histamine. BALB/c mice were orally administrated with KOB (500 mg/kg), ARW (100 mg/kg) or anti-histamine drug, Ketotifen (10 mg/kg) as a reference drug, followed by sensitization and challenge of OVA. Mice were measured the serum levels of histamine and IgE, and observed histopathological changes of nasa mucosa H&E staining. Results : KOB and ARW significantly decreased the mortality and the serum levels of histamine in compound 48/80-induced anaphylatic rats. KOB and ARW also decreased the serum levels of histamine and IgE in OVA-induced AR mice, and inhibited histopathological changes of nasal mucosa with inflammation and the eosinophils infilteration. Conclusions : These data suggest that KOB has a strong anti-allergic effect through the inhibitory property of Astragali Radix, the main component of KOB against allergic responses in allergic rhinitis.

Keywords

References

  1. Korean Journal of Asthma, Allergy and Clinical Immunology. Asthma and Allergy disease. Seoul : koonja publisher. 2002 ; 66 : 431-433.
  2. Lee JB , Yang HM, Min YK, Seok HS. Role of Chemokine in a in vivo Medel of Food Allergy. J Kor Soc Living Environ Sys. 2009 ; 16 : 675-682.
  3. Seoul National University College of Medicine. Immunology. Seoul : Seoul National University publisher. 1987 ; 188-197.
  4. Kim YB, Chae BY. A Clinical study on the Sneezing, Nasal discharge, Nasal obstruction. Kor J Ori Med Soc. 1993 ; 14(2) : 162-167.
  5. Kim HH. Allergic rhinitis, sinusitis and asthma: evidence for respiratory system integration. Kor J Pediatrics. 2007 ; 50(4) : 335-339. https://doi.org/10.3345/kjp.2007.50.4.335
  6. Schwartz LB, Huff TF. Biology of mast cells. In : Middleton E, editor. Allergy : Principles and practice. 5th ed. Mosby : St. Louis. 1998 ; 261-276.
  7. Spector SL. Overview of comorbid associations of allergic rhinitis. J Allergy Clin Immunol. 1997 ; 99 : S773-780. https://doi.org/10.1016/S0091-6749(97)70126-X
  8. Ahn KM. Role of mast cell in allergic inflammation and innate immunity. Korean Journal of Pediatrics. 2004 ; 47(11) : 1137-1141.
  9. Kim SH, Kim SA, Park MK, Kim SH, Park YD, Na HJ, Kim HM, Shin MK, Anh KS. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-$\alpha$. International Immunopharmacology. 2004 ; 4 : 279-287. https://doi.org/10.1016/j.intimp.2003.12.013
  10. Kawakami T, Galli SJ. Regulation of mast cell and basophil function and survival by IgE. Nature Reviews Immunology. 2002 ; 2 : 773-786. https://doi.org/10.1038/nri914
  11. Poole JA, Rosenwasser LJ. The role of immunoglobulin E and immune inflammation: implications in allergic rhinitis. Curr Allergy Asthma Rep. 2005 ; 5(3) : 252-258. https://doi.org/10.1007/s11882-005-0045-5
  12. Kim YJ, Park SJ, Kim TJ. Anti-Allergic Effects of Nodakenin in IgE/Ag-Induced Type I Hypersensitivity. Kor J Sci. 2011 ; 21 : 1721-1725. https://doi.org/10.5352/JLS.2011.21.12.1721
  13. Jung JK, Jung HM, Seo WG, Park YK. Anti-allergic effect of Osterici Radix water extract in human mast cells. Kor J Herb. 2010 ; 25(3) : 35-41.
  14. Jung JK. Park YK. Effect of modified -okbyungpoongsan on mast cell-mediated allergic responses in RBL-2H3 mast cell. Kor J Herb. 2011 ; 26(4) : 1-7.
  15. Ahn DK, Nac HS. Oriental medicine and immunology. Paju : openbooks. 1994 ; 15-48.
  16. Bae JH, Yoo JH, Kil GJ. Effects of NR on production levels of cytokines and distribution of BAL cells in allergic asthma. Kor J Herb. 2010 ; 25(1) : 33-38.
  17. Jung JK. Park YK. Anti-allergic effect of okbyungpoongsan-hap-changijasan. Kor J Herb. 2010 ; 25(2) : 55-63.
  18. The whole country a college of Oriental medicine The joint textbook publish commission compilation. Herbalogy. seoul：younglimsa. 2007 ; 579-580.
  19. Li CY, Rhee HI. Antioxidant Activity of Astragalus membranaceus Extracts. J Agr Sci. 2004 ; 15 : 103-110.
  20. Kang H, Bae HS, Ahn KS. Astragali Radix Increases Survival and Activity of Spleen Lymphocytes. Kor J Ori Med Phy & Path. 2001 ; 15(4) : 560-565.
  21. Kim EJ, Oh OJ, Lee SK, Yang KS. Inhibitory effect of Astragali Radix on COX-2 activity. Kor J Phar. 2001 ; 32(4) : 311-315.
  22. Song BK, Lee EJ, Kim HK, Jin SD, Kim SJ, Kim DH. Effects of Astragali Radix on the Function of Murine Immunocytes in Vivo and in Vitro. Kor J Herb. 1998 ; 13(2) : 115-128.
  23. HS Nak. Immunity and Traditional Oriental Medicine. Openbooks. 1994 ; 19-48.
  24. Kim KJ. Treatment for allergic rhinitis reported of gyejitanggamibang. J Ori Med Surgery, Ophthalmology and Otolaryngology. 1989 ; 10(1) : 99- 106.
  25. Shin JW, Kim NK. A Clinical study of Allergic Rhinitis(treated with aroma-therapy). J Kor Ori Med. 2000 ; 21(4) : 174-182.
  26. Jeon SY. Controversies in Management of Allergic Rhinitis: Immunotherapy vs. Medical Therapy. J Clinical Otolaryngol. 2000 ; 11 : 23-26.
  27. Church MK, Bradding P, Walls AF, Okayama Y. Human mast cells and basophils. In Allergy and allergic dieases. 1st ed. MA : Blackwell Science. 1997 : 149-170.
  28. Hu ZQ, Zhao WH, Shimamura T. Regulation of mast cell development by inflammatory factors. Curr Med Chem. 2007 ; 14(28) : 3044-3050. https://doi.org/10.2174/092986707782793998
  29. Brown JM, Wilson TM, Metcalfe DD. The mast cell and allergic disease : role in pathogenesis and implications for therapy. Clin Exp Allergy. 2008 ; 38(1) : 4-18.
  30. Rosenwasser LJ, O'Brien T, Weyne J. Mast cell stabilization and anti-histamine effects of olopatadine ophthalmic solution: a review of pre-clinical and clinical research. Surr Med Res Opin. 2005 ; 21(9) : 1377-1387. https://doi.org/10.1185/030079905X56547

Cited by

  1. Effect of the water extract of Peucedani Japonici Radix on ovalbumin-induced allergic asthma in mice vol.28, pp.6, 2013, https://doi.org/10.6116/kjh.2013.28.6.1
  2. 곽향(藿香)의 난알부민으로 유도된 천식 마우스에서의 천식개선 효능연구 vol.30, pp.3, 2012, https://doi.org/10.6116/kjh.2015.30.3.1.