YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Ethanol Extract of Saussurea lappa Root Induces Apoptosis through an ROS-MAPKs-Linked Cascade

목향에탄올추출물의 ROS-MAPKs 경로를 통한 세포사멸 유도

  • Kim, Dae-Sung (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Sung-Jin (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jang-Cheon (Division of Pharmacology and Basic Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Woo, Won-Hong (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lim, Kyu-Sang (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Dept. of Anatomy, College of Oriental Medicine, Wonkwang University)
  • 김대성 (원광대학교 한의학전문대학원) ;
  • 이성진 (원광대학교 한의학전문대학원) ;
  • 이장천 (부산대학교 한의학전문대학원) ;
  • 우원홍 (원광대학교 한의학전문대학원) ;
  • 임규상 (원광대학교 한의학전문대학원) ;
  • 문연자 (원광대학교 한의과대학)
  • Received : 2012.04.09
  • Accepted : 2012.05.22
  • Published : 2012.06.30
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Abstract

Saussurea lappa (SL) and major compounds, sesquiterpene lactones, have been suggested to possess various biological effects, including anti-tumor, anti-ulcer, anti-inflammatory, anti-viral and cardiotonic activities. Therefore, the ethanol extract of Saussurea lappa root (ESL) is studied for the mechanism of its action in apoptotic pathway. ESL-treated cells manifested nuclear condensation, and fragmentation. ESL also triggered the mitochondrial apoptotic pathway, as indicated by a change in Bax/Bcl2 ratio and caspase-9/-3 activation. ESL induced p38 MAPK/JNK, p53, and ASK1 phosphorylation. ROS scavenger reversed ESL-induced apoptotic cell death via inhibition of caspase-3 and p38 MAPK/JNK phosphorylation. These results suggest that ESL induced apoptosis in HepG2 cells through the ROS-p38/JNK pathway.

Keywords

References

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