Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Brain Metastases from Cholangiocarcinoma: a First Case Series in Thailand

  • Chindaprasirt, Jarin (Medical Oncology Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Sookprasert, Aumkhae (Medical Oncology Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Sawanyawisuth, Kittisak (Ambulatory Medicine Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Limpawattana, Panita (Ambulatory Medicine Division, Department of Medicine, Facult of Medicine, Khon Kaen University) ;
  • Tiamkao, Somsak (Neurology Division, Department of Medicine, Facult of Medicine, Khon Kaen University)
  • Published : 2012.05.30
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Abstract

Background: Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. Methods: Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. Results: The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. Conclusion: This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.

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References

  1. Choi HJ, Cho BC, Sohn JH, et al (2009). Brain metastases from hepatocellular carcinoma: prognostic factors and outcome. J Neuro-Oncol, 91, 307-13. https://doi.org/10.1007/s11060-008-9713-3
  2. Craighead PS, Chan A (2012). Defining treatment for brain metastases patients: nihilism versus optimism. Support Care Cancer, 20, 279-85. https://doi.org/10.1007/s00520-010-1068-6
  3. Eckman KR, Patel DK, Landgraf A, et al (2011). Chemotherapy Outcomes for the Treatment of Unresectable Intrahepatic and Hilar Cholangiocarcinoma: A Retrospective Analysis. Gastrointest Cancer Res, 4, 155-60.
  4. Eichler AF, Loeffler JS (2007). Multidisciplinary Management of Brain Metastases. The Oncologist, 12, 884-98. https://doi.org/10.1634/theoncologist.12-7-884
  5. Gudesblatt MS, Sencer W, Sacher M, Lanzieri CF, Song SK (1984). Cholangiocarcinoma presenting as a cerebellar metastasis: case report and review of the literature. J Comput Tomogr, 8, 191-5.
  6. Jemal A, Bray F, Center MM, Ferlay J, Ward E Forman D (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  7. Jiang XB, Ke C, Zhang GH, et al (2012). Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors. BMC Cancer, 12, 49. https://doi.org/10.1186/1471-2407-12-49
  8. Jiang XB, Yang Q-Y, Sai K, et al (2011). Brain metastases from colorectal carcinoma: a description of 60 cases in a single Chinese cancer center. Tumour Biol, 32, 1249-56. https://doi.org/10.1007/s13277-011-0229-7
  9. Jung M, Ahn JB, Chang JH, et al (2011). Brain metastases from colorectal carcinoma: prognostic factors and outcome. J Neuro-Oncol, 101, 49-55. https://doi.org/10.1007/s11060-010-0214-9
  10. Kamsa-ard S, Wiangnon S, Suwanrungruang K, et al (2011). Trends in liver cancer incidence between 1985 and 2009, Khon Kaen, Thailand: cholangiocarcinoma. Asian Pac J Cancer Prev, 12, 2209-13.
  11. Kidambi T, Mahajan A, DiBardino D (2011). Cholangiocarcinoma presenting as metastases to the cervical spine. Am J Med, 24, 1-2.
  12. Li J, Henry MR, Roberts LR (2011). Rare distant skeletal metastasis from hilar cholangiocarinoma: report of a case. J Gastrointest Cancer, 42, 171-3. https://doi.org/10.1007/s12029-010-9237-x
  13. Li Q, Li HK, Hao XS (2009). Analysis of the surgical outcome and prognostic factors for hilar cholangiocarcinoma. Zhonghua Wai Ke Za Zhi, 47, 94-7.
  14. Mimatsu K, Oida T, Kawasaki A, et al (2011). Long-term survival after resection of mass-forming type intrahepatic cholangiocarcinoma directly infiltrating the transverse colon and sequential brain metastasis: Report of a case. Surg Today, 41, 1410-3. https://doi.org/10.1007/s00595-010-4500-0
  15. Nanashima A, Tobinaga S, Abo T, et al (2012). Experience of surgical resection for hilar cholangiocarcinomas at a Japanese single cancer institute. Hepatogastroenterology, 59, 347-50.
  16. Niwiriska A, Murawska M, Pogoda K (2010). Breast cancer brain metastases: differences in survival depending on biological subtype, RPA RTOG prognostic class and systemic treatment after whole-brain radiotherapy (WBRT). Ann Oncol, 21, 942-8. https://doi.org/10.1093/annonc/mdp407
  17. Okamura Y, Harada A, Maeda A, et al (2008). Carcinomatous meningitis secondary to cholangiocarcinoma without other systemic metastasis. J Hepatobiliary Pancreat Surg, 15, 237-9. https://doi.org/10.1007/s00534-007-1249-y
  18. Park MH, Cho JS, Lee JS, Kim HK, Yoon JH (2012). Thyroid gland metastasis arising from primary liver cholangiocarcinoma: The first case report involving surgical operation. Int J Surg Case Rep, 3, 78-81. https://doi.org/10.1016/j.ijscr.2011.11.001
  19. Sen M, Demiral AS, Cetingöz R, et al (1998). Prognostic factors in lung cancer with brain metastasis. Radiother Oncol, 46, 33-8. https://doi.org/10.1016/S0167-8140(97)00124-2
  20. Shaib Y, El-Serag HB (2004). The epidemiology of cholangiocarcinoma. Semin Liver Dis, 24, 115-25. https://doi.org/10.1055/s-2004-828889
  21. Shin HR, Oh JK, Masuyer E, et al (2010). Epidemiology of cholangiocarcinoma: an update focusing on risk factors. Cancer Sci, 101, 579-85. https://doi.org/10.1111/j.1349-7006.2009.01458.x
  22. Shuangshoti S, Rungruxsirivorn S, Panyathanya R (1989). Intracranial metastasis of hepatic carcinomas: a study of 9 cases within 28 years. J Med Assoc Thai, 72, 307-13.
  23. Sripa B, Pairojkul C (2008). Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol, 24, 349-56. https://doi.org/10.1097/MOG.0b013e3282fbf9b3
  24. Tao LY, He XD, Qu Q, et al (2010). Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a case-control study in China. Liver Int, 30, 215-21. https://doi.org/10.1111/j.1478-3231.2009.02149.x
  25. Thongprasert S (2005). The role of chemotherapy in cholangiocarcinoma. Annals Oncol, 16, 93-6. https://doi.org/10.1093/annonc/mdi712
  26. Welzel TM, Grauberd BI, El-Serag HB, et al (2007). Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study. Clin Gastroenterol Hepatol, 5, 1221-8. https://doi.org/10.1016/j.cgh.2007.05.020
  27. William BM, Grem JL (2011). Brain metastasis and leptomeningeal carcinomatosis in a patient with cholangiocarcinoma. Gastrointestinal Cancer Research, 4, 144-5.
  28. Wongkonkitsin N, Phugkhem A, Jenwitheesuk K, Saeseow OT, Bhudhisawasdi V (2006). Palliative surgical bypass versus percutaneous transhepatic biliary drainage on unresectable hilar cholangiocarcinoma. J Med Assoc Thai, 89, 1890-5.

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