The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of pear extracts containing herbal medicine(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on body weight, lipid metabolism and immune responses in rats fed high fat diets (II)

배추출물과 구기자, 의이인, 택사, 황기 추출물 배합이 고지방식이로 유발된 비만 백서의 체중, 지질대사, 염증 및 면역기능에 미치는 영향 (II)

  • Kim, Wang-In (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Youn, Dae-Hwan (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Kim, Hwang-Gon (Najubedoly) ;
  • Na, Chang-Su (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University)
  • 김왕인 (동신대학교 한의과대학 경혈학교실) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 김황곤 (나주배돌이 (영)) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실)
  • Received : 2012.08.10
  • Accepted : 2012.09.11
  • Published : 2012.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : This study was conducted to 9% compared with the previous experimental obesity-induced metabolic function in rats that it was a mixture of pear extract and herbal drugs(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on high fat diet-induce obesity rats. Methods : The animals were used in male rats. Control group fed high-fat diet only. Experimental groups were divided four, ExpI group was fed high-fat diet with a mixture pear extract and Lycii Fructus 9%, Exp II group was fed high-fat diet with a mixture pear extract and Coicis Semen 9%, Exp III group was fed high-fat diet with a mixture pear extract and Alimatis Rhizoma 9%, and Exp IV group was fed high-fat diet with a mixture pear extract and Astragali Radix 9% for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in all Exp groups than the control group. The concentrations of serum total cholesterol (TC), LDL-cholesterol, and free fatty acid were significantly lower in Exp II than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp IV group than in the control group. In inflammatory activities, the Exp II, IV group was significantly lower than the control group. Conclusion : The results indicated that Exp I group (administered a mixture of pear extract and Lycii Fructus) reduced fat accumulation, body weight and the highest elevated lipid metabolism, while the Exp II group (administered the mixture of pear extract and Coicis Semen) and Exp IV group (administered the mixture of pear extract and Astragali Radix) had the highest elevated immune activity.

Keywords

References

  1. Hill JO, Lin D, Yakubu F, Peter JC. Development of dietary obesity in rat. influence of amount and composition of dietary fat. Int J Obes Relat Matab Disord. 1992 ; 16 : 321-33.
  2. Lee HK. Recent progress in obesity research ; Diseases associated with obseity. Korean J Nutr. 1990 ; 23 : 341-6.
  3. Kopelman PG. Obesity as a medical problem. Nature. 2000 ; 404(6778) : 635-43.
  4. Department of Internal Medicine, Collage of medicine, Seoul University. Internal medicine. Seoul : Kunja company. 1996 : 852-62.
  5. Gwakaechun. Canon of Medicine. Tianjin : Tianjin Science and Technology Publishing. 1981 : 54, 87, 183, 194, 282.
  6. Heo suyoung. Oriental and Western Medical Study on the investigation and treatment of Obesity. The Korean Academy of Oriental Rehabilitation Medicine. 1997 ; 7(1) : 272-86.
  7. Sung YY, Yoon T, Kim SJ, Yang WK, Kim HK. Anti-obesity activity of Allium fistulosum L. extract by down-regulation of the expression of lipogenic genes in high-fat diet-induced obese mice. Mol Med Report. 2011 ; 4(3) : 431-5.
  8. Sung YY, Yoon T, Yang WK, Kim SJ, Kim HK. Anti-obesity effects of Geranium thunbergii extract via improvement of lipid metabolism in high-fat diet-induced obese mice. Mol Med Report. 2011 ; 4(6) : 1107-13.
  9. Niu C, Chen C, Chen L, Cheng K, Yeh C, Cheng J. Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPAR${\alpha}$ in liver of mice fed high-fat diet. Horm Metab Res. 2011 ; 43(9) : 625-30. https://doi.org/10.1055/s-0031-1283147
  10. Yamamoto N, Kanemoto Y, Ueda M, Kawasaki K, Fukuda I, Ashida H. Anti-obesity and anti-diabetic effects of ethanol extract of Artemisia princeps in C57BL/6 mice fed a high-fat diet. Food Funct. 2011 ; 2(1) : 45-52. https://doi.org/10.1039/c0fo00129e
  11. Lai P, Du JR, Zhang MX, Kuang X, Li YJ, Chen YS, He Y. Aqueous extract of Gleditsia sinensis Lam. fruits improves serum and liver lipid profiles and attenuates atherosclerosis in rabbits fed a high-fat diet. J Ethnopharmacol. 2011 ; 137(3) : 1061-6. https://doi.org/10.1016/j.jep.2011.06.023
  12. Yoon GR. Biological effects of Allium monanthum extracts on the lipid metabolism, anti-oxidation and pro-inflammatory cytokines production in rat fed high fat diet. Sangji University Graduate School. 2011.
  13. Park WH. Effects of stem bark extracts of Cornus walteri Wanger on the lipid lowering, anti-oxidative activity and concentration of proinflammatory cytokines in rat fed high fat diet. Sangji University Graduate School. 2009.
  14. National Task Force on the Prevention and Treatment of Obesity. Dieting and the development of eating disorders in overweight and obses adults. Arch Intern Med. 2000 ; 160(17) : 2581-9. https://doi.org/10.1001/archinte.160.17.2581
  15. Rucker D, Padwal R, Li SK, Curioni C, Lau DC. Long term pharmacotherapy for obesity and overweight : updated meta-analysis. BMJ. 2007 ; 335(7631) : 1194-9. https://doi.org/10.1136/bmj.39385.413113.25
  16. Jingyujeong. Explain of BenCaoGangMu(本草綱目通釋). Beijing : Hakwon company. 1992 : 1449-50.
  17. Na CS, Yun DH, Choi DH, Jeong JG, Eun JB, Kim JS. The Effect of Pear Pectin &. Phenolic Compounds on Regional Cerebral Blood Flow, Mean Arterial Blood Pressure, Heart Rate and Cardiac Contractile Force in Hypertensive Rat Induced by 2K1C. Kor J herbology. 2003 ; 18(2) : 101-8.
  18. Na CS, Yun DH, Choi DH, Kim JS, Cao CH, Eun JB. The Effect of Pear Pectin on Blood Pressure, Plasma Renin, ANP and Cardiac Hypertrophy in Hypertensive Rat Induced by 2K1C. J Korean Soc Food Sci Nutr. 2003 : 32(5) ; 700-5. https://doi.org/10.3746/jkfn.2003.32.5.700
  19. Kim JS, Na CS. Effect of Rehmanniae Radix and Pear Phenolic Compound on the STZ-Treated Mice for Induction of Diabetes. J Kor Soc Food Sci Nutr. 2004 ; 33(1) : 66-71. https://doi.org/10.3746/jkfn.2004.33.1.066
  20. Choi CH, Yun DH, Kim JH, Jeong JG, Na CS. The Effects of Pear Phenolic Compound and Herbal Drugs According to the dose and Duration on the Respiratory System of Asthma Mice Induced by Ovalbumin. Kor J Herbology. 2008 ; 23(4) : 135-47.
  21. Lee JC, Pak SC, Lee SH, Na CS, Lim SC, Song CH, Bai YH, Jang CH. Asian pear pectin administration during presensitization inhibits allergic response to ovalbumin in BALB/c mice. J Altern Complement Med. 2004 ; 10(3) : 527-34. https://doi.org/10.1089/1075553041323867
  22. Yukio Nemoto, Kazuo Torizuka, Yoshiteru Ida. Shokan-kinki Yakubutsu Jiten. Seoul : Jisangsa. 2011 : 141-3, 172, 179-81, 197-8.
  23. Kim HC. Oriental pharmacology. Seoul : Jipmoondang. 2001 : 225-29, 427-29, 479-81
  24. Hwang EY, Hong JH, Choi JH, Lee EJ, Lee IS. Study on Anti-obesity and Hypoglycemic Effects of Lycium chinense Mill Extracts. J Korean Soc Food Sci Nutr. 2009 ; 38(11) : 1528-34. https://doi.org/10.3746/jkfn.2009.38.11.1528
  25. Kim SE, Rhyu DY, Yokozawa T, Park JC. Antioxidant Effect of Alisma plantago-aquatica var. orientale and Its Main Component. Kor J Pharmacogn. 2007 ; 38(4) : 372-75.
  26. Kim JW, Kim SD, Youn KS. Antioxidant Activity of Hwangki and Beni-Koji Extracts and Mixture. J Korean Soc Food Sci Nutr. 2011 ; 40(1) : 1-6. https://doi.org/10.3746/jkfn.2011.40.1.001
  27. Lee YJ, Sohn YJ, Lee ES, Park JS, Kim SK. Effects of coicis semen the hyperlipidemia in rat. Kor J Herbology. 2004 ; 19(3) : 129-36.

Cited by

  1. Beneficial effect of Combination with Korean Red Ginseng and Morus alba in metabolic syndrome vol.27, pp.6, 2012, https://doi.org/10.6116/kjh.2012.27.6.99
  2. 대금음자가미와 이(梨)추출물 배합제제가 알코올로 유발된 간손상에 미치는 영향 vol.30, pp.1, 2012, https://doi.org/10.6116/kjh.2015.30.1.51.